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Biomedical subjects

E A Zherbin

Publications and source records attributed to E A Zherbin.

62 records · Page 4Linked to original sources
PubMedDate not supplied

[Proteinase inhibitors of the blood plasma in the early period of the development of acute radiation sickness in monkeys].

A study was made of the postirradiation kinetics of blood antiproteinase activity in monkeys (Macaca nemestrina). Whole-body uniform gamma-irradiation (LD100/45) was shown to induce a significant decrease in the activity of alpha 2-macroglobulin during the first 24 h following irradiation: the decreased activity level was retained throughout the entire latent period of radiation sickness. At the height of radiation sickness (the 7th-10th day) up to the animals' death, a sharp increase was registered in the activity of alpha 1-inhibitor of blood plasma proteinases. The authors discuss a pathogenetic role of the diminution of the inhibitory potential of blood in the course of radiation sickness.

Acute Disease↗
PubMedDate not supplied

[Effect of gamma- and gamma-neutron irradiation on the composition of the metabolic amino acid pool, blood antiprotease activity and the life-span of animals].

A study was made of the effect of gamma- and gamma-neutron-radiation, with neutron energy of 0.9 MeV, on the free amino acid composition and antiprotease activity of blood as well as on the life span of albino mongrel rats. The data obtained indicate that changes in the metabolic pool of blood amino acids and inhibitory capacity of blood with respect to alpha 2-macroglobulin depend upon the type and dose of radiation. An attempt is made to find a correlation between early changes in the metabolic pool of amino acids and antiprotease activity and the degree of life span shortening after gamma- and gamma-neutron irradiation.

Amino Acids↗
PubMedDate not supplied

[Relative biological effectiveness of gamma-neutron irradiation with neutron energy of 0.9 MeV].

Relative biological effectiveness (RBE) of gamma-neutron radiation with neutron energy of 0.9 MeV was estimated with a reference to rat death. It was shown that RBE of gamma-neutron radiation (the share of neutrons was 67% as related to dose) at LD33/30 and LD100/30 was 2, and RBE of 0.9 MeV neutrons, in experiments with mixed radiation, was 3.1 and 2.86 at LD33/30 and LD100/30, respectively. The value of a maximum dose at which death was not registered during 30 days, was 1 Gy with gamma-neutron radiation and 4 Gy with X-radiation.

Animals↗
PubMedDate not supplied

[Relation between various cytological parameters of cultured irradiated thymus cells].

Bat thymocytes were incubated in a medium with isologous serum. During the first hours following gamma-irradiation alongside with the nuclear pyknosis a dose-dependent decrease in the ability of formation of rosettes with autologous erythrocytes and inhibition of mitotic activity were noted. A conclusion is made of a possible relationship between postirradiation disturbances of membranes and thymocyte nuclei.

Animals↗