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Biomedical subjects

E B Ing

Publications and source records attributed to E B Ing.

17 recordsLinked to original sources
PubMed1998

Solitary fibrous tumor of the orbit.

Solitary fibrous tumor (SFT) of the orbit is a very rare lesion that may be misdiagnosed as fibrous histiocytoma, hemangiopericytoma, or other orbital tumors. We present a 62-year-old man who presented with painless proptosis, 20 years following left eye enucleation for a presumed neurofibroma. On T2-weighted magnetic resonance imaging (MRI), a hypointense tumor almost filled his entire left orbit. There was no intracranial extension. The specimen obtained at orbital exenteration was consistent with the histologic, immunohistochemical, and electron microscopic findings of SFT. The tumor was positive for vimentin and CD34 staining but negative for S-100 protein and epithelial membrane antigen. Only nine other cases of SFT of the orbit have been documented in the literature. Recognition of SFT of the orbit as a distinct pathologic entity and further follow-up of published cases are needed to determine the prognosis of this rare lesion.

Antigens, CD34↗
PubMed1997

Sarcoid masquerading as optic nerve sheath meningioma.

Sarcoid manifesting as an optic nerve tumor without evidence of systemic disease is uncommon. Throughout a 2-year period, a 22-year-old white woman had progressive monocular loss of vision to the level of no light perception. Optic atrophy but no uveitis was noted in the affected eye. Magnetic resonance imaging revealed thickening and enhancement of the apical optic nerve, with "tram-tracking." The presumptive diagnosis was optic nerve sheath meningioma; however, a biopsy specimen from the optic nerve revealed sarcoid. Extensive postoperative investigations revealed no systemic sarcoidosis. To our knowledge, 17 cases similar to ours, with the diagnosis proved by optic nerve biopsy, have been previously reported in the English-language literature. Most of these were mistaken preoperatively for optic nerve sheath meningioma. None of the patients had evidence of systemic sarcoidosis on initial postoperative testing. Neuroimaging, serum level of angiotensin-converting enzyme, and clinical characteristics such as age, race, sex, and optochoroidal collaterals do not distinguish optic nerve sheath meningioma from sarcoid of the optic nerve. In the absence of uveitis or systemic involvement, optic nerve sarcoid manifesting as an orbital tumor is virtually impossible to diagnose without results of biopsy.

Adult↗
PubMed1997

Systemic amyloidosis with temporal artery involvement mimicking temporal arteritis.

A 77-year-old man presented with jaw claudication, arthralgias and myalgias, weight loss, marked fatigue, and thickened temporal arteries. No vasculitis was seen on the temporal artery biopsy specimen, but amyloidosis was suspected and confirmed with Congo red staining. Subsequent bone marrow biopsy revealed multiple myeloma. Although the patient initially was thought to have temporal arteritis, the results of temporal artery biopsy directed further investigations that led to the diagnosis of systemic amyloidosis. Systemic amyloidosis should be considered in the differential diagnosis when patients, especially men, present with clinical findings suggestive of temporal arteritis but without evidence of vasculitis in temporal artery biopsy specimens.

Aged↗
PubMed1996

Asthma caused by topical application of ketorolac.

BACKGROUND: Ketorolac tromethamine 0.5 percent ophthalmic solution is a widely used nonsteroidal anti-inflammatory drug (NSAID) in ophthalmology. Ketorolac eye drops have not been implicated previously as a cause of NSAID-induced asthma. STUDY DESIGN: A patient with severe asthma after topical application of ketorolac is described. The current ophthalmic indications for topical application of ketorolac and reported hypersensitivity reactions with systemic use of ketorolac are reviewed. RESULTS: A 44-year-old woman with chronic asthma, rhinosinusitis, and nasal polyps inadvertently was given ketorolac to be applied topically. After applying the first dose of ketorolac, an exacerbation of her asthma developed, necessitating hospital admission. CONCLUSIONS: Topical application of ketorolac is safe in the vast majority of ophthalmology patients. However, NSAID eye drops should not be prescribed for patients with aspirin or NSAID allergy or the combination of asthma and nasal polyps unless the patient is known to tolerate aspirin without trouble.

Administration, Topical↗
PubMed1995

Hemifacial spasm and osteitis deformans.

PURPOSE/METHODS: A patient with osteitis deformans (Paget's disease) and hemifacial spasm underwent magnetic resonance tomographic angiography. Bone-modulating bisphosphonates and botulinum injection were administered to treat the hemifacial spasm. RESULTS/CONCLUSIONS: Computed tomography showed marked temporal bone overgrowth. Magnetic resonance tomographic angiography showed no vascular compression of the facial nerve root. The hemifacial spasm failed to resolve with intravenous pamidronate. Subsequent botulinum injection rendered the patient spasm free for 22 weeks. Further research on the use of bisphosphonates in the treatment of pagetoid hemifacial spasm is required.

Aged↗
PubMed1995

Pupil mnemonics.

Explore the source record for details and available documents.

Humans↗
PubMed1994

Computerized colour vision testing.

There are many advantages to the computerization of colour vision tests. However, previous computerized colour vision tests have involved equipment and methods not commonly used in clinical practice. We created computer emulations of the City University Colour Vision Test (CUT), Ishihara plates and American Optical Hardy-Rand-Rittler (AO-HRR) plates using a commonly available 24-bit colour Macintosh computer. Our colour monitor was calibrated to standard display white (D65), and colour plates were imaged with a colour scanner. The computerized colour images were compared with the standard test plates in a sample of 21 subjects with normal colour vision, 10 patients with congenital red-green defect and 1 patient with an acquired mixed colour defect. The computer images of the three tests correlated well with their conventional counterparts on kappa statistic analysis (p < 0.001), for both the colour normal and colour defective groups. We conclude that our computer emulations of the CUT, Ishihara and AO-HRR tests screen subjects with normal colour vision with high specificity and delineate congenital colour defects with a sensitivity comparable to that of their conventional counterparts.

Adult↗
PubMed1992

Periorbital hyperpigmentation and erythema dyschromicum perstans.

Erythema dyschromicum perstans is a rare idiopathic dermatosis characterized by ash-grey, well-demarcated skin lesions, which may involve the face. We describe an 8-year-old girl with erythema dyschromicum perstans presenting as bilateral acquired periorbital hyperpigmentation. The changes seen on histologic study of a skin biopsy specimen were consistent with the clinical diagnosis. The various causes of periorbital hyperpigmentation and characteristics of erythema dyschromicum perstans are reviewed.

Biopsy↗
PubMed1992

A method of teaching indirect ophthalmoscopy to beginning residents.

The authors describe an effective tool for teaching indirect ophthalmoscopy that is easily constructed from a roll of tape. The materials are inexpensive and readily available. The hollow interior of the roll affords a large pupillary opening, and one does not risk scratching the condensing lens on the metal surface of a commercial model eye.

Education, Medical, Graduate↗
PubMedDate not supplied

Lung cancer with visual loss.

A 58-year-old man with primary large cell carcinoma of the lung presented with rapidly progressive, bilateral visual loss. The patient was alert and oriented, had no complaints of headache, and was found to have full ocular motility. The optic disks and fundi appeared normal. No visual pathway lesions or other CNS abnormalities were detected on neuro-imaging. The authors discuss their differential diagnosis, clinical diagnostic approach, and subsequent management of this unusual patient.

Carcinoma, Large Cell↗
PubMedDate not supplied

Progressive visual loss and motility deficit.

A 63-year-old female with known stage III, low grade non-Hodgkin's lymphoma presented with progressive visual loss in the left eye and binocular diplopia in all positions of gaze. The left globe was almost immotile. Two MRI's of the orbit were interpreted as normal. Lumbar puncture did not reveal abnormal cytology. Although orbital apex involvement is uncommon in non-Hodgkin's lymphoma, the patient's clinical findings clearly indicated a lesion in this area, which was confirmed by a third MRI. Review of one of the initial films showed evidence of orbital apex involvement. To prevent diagnostic delay and unnecessary repeat imaging, the clinical diagnosis of orbital apex syndrome should be clearly communicated to the radiologist. Prompt recognition of orbital apex syndrome may improve visual outcome.

Disease Progression↗
PubMedDate not supplied

Oculomotor nerve palsies in children.

Fifty-four patients with oculomotor nerve palsy who presented over a 21-year period at our institution were reviewed retrospectively. There were 38 isolated third nerve lesions, and 16 with additional cranial nerve involvement. Eleven cases were congenital in origin, and 43 were acquired. Of the acquired group, 31 were traumatic, 7 infection-related, 3 attributed to migraine or other vascular causes, and 2 neoplastic. Average follow up was 36 months. The congenital lesions were predominantly right-sided; amblyopia, although common, responded well to treatment. Trauma and bacterial meningitis accounted for more cases of isolated oculomotor nerve palsy than seen in the previous literature. In distinct contrast to the adult population, no cases of diabetes, posterior communicating artery aneurysms, metastatic tumors, or pituitary lesions were found.

Adolescent↗