A new synthetic material was developed by ASAHI Chemical Industry Co., Ltd., Tokyo, Japan. In vitro studies revealed selective bindings of cholesterol, LDL (low density lipids) and beta-lipoprotein by this material. Maximal bindings were reached within 1 min, and therefore, the affinities of the LDL-adsorbent to these lipid components seem to be high. In contrast to these results the plasma values of HDL (high density lipids) and apoprotein A remained nearly unchanged. Triglycerides were removed only moderately. Investigations about lipid removing capacity of the new material with the plasma of patient with familiar hypercholesterolemia and studies about interactions with the complement system were also promising. Synthetic materials which are under development in G.D.R. showed similar lipid binding capacities.

Acrylic Resins↗

PubMedDate not supplied

[Analysis of soluble antigens of the human striated musculature. I. Electrophoretic analysis and enzyme determinations].

Human skeletal muscle was extracted at pH 7. The supernatant of centrifugation at 100 000 X g for 1 h was analysed with different elektrophoretical methods and examined for activities of nine enzymes. These studies revealed an unique pattern of proteins in muscle extracts in comparison to human serum and differences of enzyme activities in both fluids. The bulk of muscle proteins migrated electrophoretically in the region of beta-and gamma-globulins. At least 10 substances or groups of substances could be detected in 100 000 X g supernatants of muscle extracts. The results are presuppositions for further analytical studies of muscle proteins with immunochemical methods.

Antigens↗

PubMedDate not supplied

[Immune RNA and the immune response].

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Animals↗

PubMedDate not supplied

Cell electrophoretic characterization of lymphoid cells from various sources in patients with malignant non-Hodgkin lymphomas.

Lymphocytes of 36 patients with malignant Non-Hodgkin lymphomas (NHL) were characterized by electrophoretic mobility (EPM) and EAC-rosette and E-rosette formation. Unimodal cytopherograms found in patients with low-grade malignant NHL are compatible with a monoclonal origin of the proliferating lymphoid cells. Within the CLL subgroup, deviations from the general mean EPM value in the intermediumrange were not unequivocally related to the B- or T-cell origin of the lymphocytes and remain to be explained. Comparing distinct entities of low-grade malignant NHL characterized by lymphocyte arrest at a certain stage of differentiation (Kiel Classification) we found an increase of the mean EPM in the direction of CLL----lymphoplasmacytoid immunocytoma----polymorphic immunocytoma. This arrest of leukemic cells at a certain EPM level may support a cytogenetically oriented subclassification of NHL. The Limitations of the diagnostic value of cytopherograms and rosette formation in malignant NHL--especially in those of high malignancy--are outlined.

Bone Marrow↗