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Biomedical subjects

E Bourke

Publications and source records attributed to E Bourke.

At least 91 records · Page 5Linked to original sources
PubMed1973

Glucose utilization and production by the dog kidney in vivo in metabolic acidosis and alkalosis.

Using D-[1-(14)C]glucose as a tracer, renal glucose utilization and production was measured in chronic metabolic acidosis and alkalosis in dog kidney in vivo. In six experiments in acidosis, mean total renal glucose production was 4.447+/-1.655 SE mumol/min and glucose utilization was 4.187+/-0.576 SE mumol/min. In five alkalotic experiments it was found that mean total glucose production was 12.227+/-2.026 SE mumol/min and glucose utilization was 18.186+/-2.054 SE mumol/min. Renal glucose utilization and production are therefore significantly higher in alkalosis than in acidosis in vivo. Since glucose production is maximal under conditions when glutamine extraction is minimal (i.e. alkalosis), it is apparent that in alkalosis glutamine is not a major precursor of glucose.

Acidosis↗
PubMed1972

Bumetanide: potent new "loop" diuretic.

Bumetanide, a pharmacologically new diuretic, was evaluated in 27 subjects. Its onset of action was within 30 minutes with a peak at 90 minutes and a total duration of action of about 270 minutes. In a controlled study in oedematous patients it was equipotent with frusemide at one-fortieth the molar dosage and did not differ from frusemide with regard to its pattern of electrolyte excretion. On continuous oral administration for eight days it produced effective diuresis with minimal alteration in biochemical and haematological status. The only adverse effect was gastric discomfort in one patient.

Administration, Oral↗