Biomedical subjects
Publications and source records attributed to E Calderón.
A patient with typical varicella (chickenpox) developed several complications: nephrotic syndrome following glomerulonephritis, trombocytopenic purpura, gastrointestinal bleeding, disseminated intravascular coagulation, encephalitis and bronchopneumonia. The course was satisfactory having been given antibiotics, heparin and peritoneal dialysis. Recovery was 100%.
Landry-Guillain-Barré-Strohl syndrome or polyradiculoneuritis in children is becoming more common. The clinical picture is variable, it may be manifested by motor and sensory findings or by a combination of peripheral and cranial nerve signs and symptoms. This is a report of 60 patients observed at the DIF Children's Hospital between 1971 and 1977. The most significant early predictor of eventual incomplete recovery was the time required for improvement to begin after the maximum involvement was reached.
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Hypertrophic pyloric stenosis diagnosis is made clinically, radiologically and by abdominal ultrasound. We present here our experience in tween.
The persistence of passively adquired measles hemagglutination-inhibition (HI) antibody, was studied in a group of 50 mother-child binomials. In this longitudinal study, serial samples of blood were obtained from each infant during the first eight months of life. There was a high correlation between the level of the antibody titer in mothers and in their newborns. Passively antibody titers between 1:20 to 1:80, persisted as late as 8 months in more than 60% of infants. The presence of antibody may have a suppressive effect on the immunogenic response to live measles virus vaccine.
Clinical and autopsy data indicate that ventriculitis persists despite parenteral and intralumbar antibiotic therapy. In the present study, ventriculitis was documented as postmortem examination in nine newborns. These studies indicate that ventriculitis occurs commonly in neonates with meningitis, particularly when there is delayed sterilization of CSF culture, A clinician has to bear in mind the diagnosis of ventriculitis when: 1) There is poor clinical and/or laboratory response to the usual therapy. 2) He has a critically ill patient with lethargy, convulsions and bulging fontanels. 3) He culture an unusual organism. 4) He faces a suspected complication of meningitis: subdural effusion, ventriculitis or abscess. 5) A CSF from ventricular puncture with more than 150 WBC, glucose less than 50 mg. and protein more than 200 mg.
Levels of Cephaloridine and Cefazoline were measured in serum, pus and bone in 20 patients with chronic osteomyelitis and the efficiency of these drugs in the treatment of osteomyelitis was evaluated.
The steps for diagnosis and treatment and the clinical course followed in three patients with Cryptococcus meningitidis are discussed. One of them was treated with 5-flurocytosine alone. Two consecutive patients were treated with a combination of 5-flurocytosine and amphotericin B. The objectives of the study were: a) to achieve a therapeutic response better than that which might be obtained with either drug alone, b) to use lower doses of 5-fluorocytosine and amphotericin B in order to reduce toxicity, c) to extend treatment only for a period of four weeks, thus decreasing the period of hospitalization. None of the patients has relapsed. A shorter time of hospitalization and reduction in toxicity, suggests that combined therapy is a safe and effective alternative to other regimens.