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Biomedical subjects

E Cronin

Publications and source records attributed to E Cronin.

At least 19 recordsLinked to original sources
PubMed1992

Diagnosis of lichen planus pemphigoides in the absence of bullae on normal-appearing skin.

A case of lichen planus pemphigoides is described in which bullae and erosions affected the areas of lichen planus only. The diagnosis was confirmed by the finding of linear C3 and IgG deposition in the basement membrane zone (BMZ) of perilesional skin. Indirect immunofluorescence revealed circulating IgG anti-BMZ antibodies and a lamina lucida split was demonstrated by electron microscopy. This case challenges the clinical dogma that the occurrence of bullae on normal-appearing skin is essential for the diagnosis of lichen planus pemphigoides.

Humans↗
PubMed1992

Recalcitrant pyoderma gangrenosum--two cases successfully treated with cyclosporin A.

The successful use of cyclosporin A (CSA) in organ transplantation is now well established. In recent years its usefulness has extended to the treatment of cutaneous autoimmune disorders, including pyoderma gangrenosum (P.G.). We report two further cases of recalcitrant P.G., both associated with rheumatoid arthritis (R.A.) which responded to low dose CSA.

Aged↗
PubMed1992

Final diagnoses in patients referred for patch testing.

The final diagnoses made in 989 patients consecutively patch tested in 1990 have been reviewed. Among the men, their dermatitis was entirely occupational in 17.9% and partially so in 12.5%. Among the women, it was entirely occupational in 6.4% and partially so in 9.5%. In both groups, irritants exceeded allergens as the cause, whereas allergens superseded irritants in the patients with a non-occupational eczema caused or aggravated by external factors. It seems likely that domestic irritants were overlooked in patients with a non-occupational dermatitis.

Adult↗
PubMed1991

Formaldehyde is a significant allergen in women with hand eczema.

Among patients consecutively patch tested at St John's from 1984-1989, the prevalence rate of formaldehyde sensitivity was 2.2% for men and 3.7% for women. During these 6 years, 117 women were primarily sensitized by formaldehyde, of whom 61 (52%) had hand eczema. Exposure was occupational in 12% and domestic in 88%. Cleaning products were the main source of exposure in the domestic group. 20 women with hand eczema avoided formaldehyde and their hands healed in 2, greatly improved in 11 and were better in 7.

Allergens↗
PubMed1990

Immediate and delayed photocontact dermatitis from isopropyl dibenzoylmethane.

Immediate and delayed photocontact dermatitis from the UVA absorber isopropyl dibenzoylmethane is described in 1 patient. In a dose response study in a 2nd patient with delayed photocontact dermatitis, the minimal dose of UVA needed to elicit a positive photopatch to isopropyl dibenzoylmethane 2% was determined to be 2 J/cm2.

Adult↗
PubMed1989

Lichen planus pemphigoides.

Lichen planus pemphigoides is a rare disease in which blistering occurs in association with lesions of classical lichen planus. We describe a patient with lichen planus pemphigoides and discuss the evidence for there being one disease rather than the coincidence of bullous pemphigoid and lichen planus.

Adult↗
PubMed1988

Frequency of sensitisation to the preservative Kathon CG.

The incidences of sensitisation to Kathon CG are reported for patients routinely tested from 1984 to 1986 in Bari, London, Louvain, Nijmegen, Oulu and San Francisco. For these 3 years, the overall frequency of sensitisation varied for women from 3.3% in Oulu to 0.6% in London and San Francisco and for men from 1.4% in Oulu to 0% in San Francisco. Women were predominantly sensitised, probably by cosmetics, toiletries and domestic cleaners. Occupational sensitisation was much less frequent.

Cosmetics↗
PubMed1987

Dermatitis of the hands in caterers.

Hand eczema among 50 caterers was occupational in 47 and endogenous in 3 cases. Irritants were considered more important than sensitisers. There was a correlation between atopy and sensitisation to type-I but not type-IV allergens. The commonest type-I sensitiser was fish and for type-IV was garlic. Dilutions of garlic and of onion 50% in arachis oil were not irritant and seemed effective patch test materials. The prognosis was not good and the hand eczema continued even in some of those who changed their jobs.

Adolescent↗
PubMed1987

Sensitivity to sunscreens.

The patients sensitised to sunscreen agents who attended our Contact Dermatitis Clinic between February 1985 to March 1987 have been reviewed. 15 (5%) of 280 patients tested with sunscreens had positive reactions; 3 of them were allergic to more than one agent. The most frequent contact allergens were hydroxy methoxy methyl benzophenone (Mexenone) [6], followed by isopropyl dibenzoylmethane (Eusolex 8020/8021) [5], octyl dimethyl para-aminobenzoate (Escalol 507) [2], and one reaction each to butyl methoxy dibenzoylmethane (Parsol 1789), amyl dimethyl para-aminobenzoate (Escalol 506), and ethoxy ethyl-p-methoxy cinnamate (Givtan F). Positive photopatch tests were seen with isopropyl dibenzoylmethane, butyl methoxy dibenzoylmethane, para-aminobenzoate (PABA) and ethoxy ethyl-p-methoxy cinnamate, one reaction each.

Benzoates↗