Modulation of hexose uptake and insulin action by cell membrane fluidity. The effects of temperature on membrane fluidity, insulin action, and insulin binding.
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Adipose Tissue↗
Biomedical subjects
E D Finch
Publications and source records attributed to E D Finch.
Pressure, anesthetics, and membrane structure: a spin-probe study.
Fatty acid spin-probe analyses at various depths in the membrane bilayer of intact erythrocytes indicate that compressional effects of pressure and fluidizing effects of lipid-soluble anesthetics are detectable only in hydrated regions of the membrane bilayer. Since current theories of anesthetic action cannot explain these observations, a proposal to do so is outlined.
Anesthetics↗
Mobility of water bound to biological membranes. A proton NMR relaxation study.
Water proton nuclear magnetic resonance relaxation measurements have been obtained for aqueous suspensions of red cell membranes. These data support a model in which water molecules are exchanging rapidly between a bound phase with restricted motions and a free phase with dynamic properties similar to liquid water. From this model and these data, estimates are obtained for the relaxation time for bound phase water. Possible relaxation mechanisms for bound phase water are discussed and some support is found for an intermolecular interaction modulated by translational motions characterized by a diffusion constant of 10(-9) cm2/s.
Cell Membrane↗
Paramagnetic species in cataractous human lenses.
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Cataract↗
Ultrastructural changes in the rabbit lens induced by microwave radiation.
Rabbits were irradiated with 2450-MHz continuous microwave energy. Effects of the radiation on the ocular lens were assessed by slit-lamp biomicroscopic examination of the eye. Two lenses were selected for electron microscopy, one that was severely damaged and one that appeared unaffected by the radiation. There were prominent ultrastructural changes in both lenses.
Animals↗
Ascorbic acid changes in cultured rabbit lenses after microwave irradiation.
Whole body exposure of rabbits to microwave radiation causes a decrease in ascorbic acid in the lens. In our study, rabbit lenses maintained in culture medium (37 degrees C) were exposed to either pulsed or continuous wave S-band radiation for 10-15 min at power densities between 0 and 200 mW/cm-2. Total ascorbic acid was measured in selected lenses 1-3 days after irradiation. The temperature of the culture medium was measured during irradiation. Matched control lenses were exposed to similar time-temperature environments, but without microwave irradiation. Ascorbic acid decreased significantly in lenses exposed to microwave radiation. No differences were found, however, between irradiated and control lenses subjected to identical time-temperature conditions. At a given average power density, the time-temperature variation was independent of modulation. A decrease in ascorbic acid is apparently a direct thermal effect of microwave radiation in rabbit lens culture.
Animals↗
Effects of low-level microwave radiation on behavioral baselines.
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Animals↗
Low frequency electric field induced changes in the shape and motility of amoebas.
Perpendicular and parallel elongation of the giant amoeba, Chaos chaos (Chaos carolinensis), have been observed in alternating electric fields over a wide frequency range (from about 1 hertz to about 10 megahertz). The characteristics change as a function of frequency. Simple dielectric forces may be important in the production of these effects.
Amoeba↗