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PubMed · 223265

Pressure, anesthetics, and membrane structure: a spin-probe study.

E D Finch·L A Kiesow
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Abstract

Fatty acid spin-probe analyses at various depths in the membrane bilayer of intact erythrocytes indicate that compressional effects of pressure and fluidizing effects of lipid-soluble anesthetics are detectable only in hydrated regions of the membrane bilayer. Since current theories of anesthetic action cannot explain these observations, a proposal to do so is outlined.

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AnestheticsChloroformElectron Spin Resonance SpectroscopyErythrocyte MembraneErythrocytesHalothaneHeliumHumansHydrostatic PressureMembrane FluidityMembrane LipidsNitrogenOctanolsPhospholipidsPressureSpin LabelsJournal ArticleResearch Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.

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E D Finch, L A Kiesow. 1979. Pressure, anesthetics, and membrane structure: a spin-probe study.. https://pubmed.ncbi.nlm.nih.gov/223265/

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