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Biomedical subjects

E Dağli

Publications and source records attributed to E Dağli.

7 recordsLinked to original sources
PubMed2005

Early pulmonary involvement in Niemann-Pick type B disease: lung lavage is not useful.

Niemann-Pick disease (NPD) is a rare, autosomal-recessively inherited lipid storage disease which is characterized by intracellular deposition of sphingomyelin in various body tissues. The disease is heterogeneous and classified into six groups. Pulmonary parenchymal involvement may be a feature of several subtypes of NPD, including type B. Progressive pulmonary involvement in NPD type B is a major cause of morbidity and mortality. It is usually diagnosed at older ages. Only a few cases with early pulmonary involvement have been reported. In this report, a patient with NPD type B, hospitalized with the diagnosis of pneumonia at age 3 months, is presented. Following treatment for pneumonia, she continued to have persistent respiratory symptoms and became oxygen-dependent. High-resolution computed tomography of the chest revealed diffuse interstitial changes. During follow-up, the patient developed hepatosplenomegaly. Lung, liver, and bone marrow biopsies showed characteristic findings for NPD. Biochemical studies also confirmed the diagnosis, and the sphingomyelinase enzyme level of the patient was low. Unilateral lung lavage was performed in order to decrease lipid storage as a treatment modality. However, there was no clinical or radiological improvement. The patient died at age 15 months due to progressive respiratory failure. Pulmonary involvement is a rare entity in early childhood in patients with NPD type B, but should be considered in the differential diagnosis of persistent interstitial lung disease. It may cause progressive respiratory failure, but the treatment options remain limited.

Bronchoalveolar Lavage↗
PubMed2000

The effect of passive smoking on the development of respiratory syncytial virus bronchiolitis.

In spite of the increasing evidence that passive smoking increases the incidence of respiratory infections and bronchial hyper-responsiveness, the information about whether exposure to sudden heavy smoke enhances the development of acute respiratory infections in children remains inadequate. In this study, to quantitate the level of exposure to environmental tobacco smoke, in 28 children (age ranging 2-18 months) with respiratory syncytial virus (RSV) bronchiolitis and in 30 children (age ranging between 2-15 months) with non-respiratory symptoms, the serum levels of cotinine, the major metabolite of nicotine, were measured at admission to the emergency department. Parents were asked to fill in a questionnaire about the housing conditions and their smoking habits. Serum samples were taken again from the children with RSV bronchiolitis at their second visit at 1 month after discharge from the hospital. The children with RSV bronchiolitis had higher levels of serum cotinine (mean of 10.8 ng/ml) in the acute stage, compared with post-bronchiolitis stage (mean of 7.4 ng/ml). Moreover, patients admitted with non-respiratory symptoms had significantly lower levels of serum cotinine (mean of 3.9 ng/ ml) than both phases of patients with RSV bronchiolitis. Children with RSV bronchiolitis were found to have higher levels of cotinine when either the mother or both of the parents smoked, than the children with non-smoker parents. In conclusion, children admitted to the hospital with RSV bronchiolitis were shown to be acutely exposed to more cigarette smoke after 1 month and much more than the children admitted for non-respiratory diseases. These findings may imply that sudden heavy cigarette smoke exposure may predispose to an acute respiratory infection.

Age Factors↗
PubMed1999

Are low income countries targets of the tobacco industry? Plenary lecture given during the Conference on Global Lung Health and 1997 Annual Meeting of the International Union Against Tuberculosis and Lung Disease, Palais des Congrès, Paris, France, 1-4 October 1997.

Estimations show that tobacco consumption is steadily increasing in low income countries already deprived of basic human needs, such as adequate food and water supplies and education. Among the many factors affecting this, the most significant is the aggressive marketing strategies of the tobacco industry. The tobacco industry operates by denying health evidence, sponsoring scientific research that diverts attention to other fields, investing heavily in promotion and advertising, interfering with national public health laws, forming joint ventures with national monopolies, and persuading governments on the risks of smuggling. Turkey, a tobacco-growing country, opened its markets to the multinational tobacco industry after 1984. This paper presents examples of the marketing strategies used by the tobacco industry in the last two decades, and shows the consequences for Turkey in the hope that this information can help other low income countries that are not yet targets of the invasion of the tobacco industry.

Agriculture↗
PubMed1986

[Tuberculous meningitis in childhood].

Tuberculous meningitis is a very important disease in childhood with poor prognosis, high mortality and severe complications. Important points of tuberculous meningitis in childhood were discussed retrospectively in the light of the results of 68 patients.

Child↗
PubMed1985

[Effect of cimetidine on the course of measles].

Cimetidine as an antagonist to histamine-2-(H2) receptor or an H2 blocker has been used in acid peptic ulcer. Its immunomodulatory effect on cell mediated immunity has recently been found. Cimetidine was also tried in herpes virus infections because its possible antiviral effect. But until now there has been no report on the use of cimetidine in measles. This study shows that cimetidine provides a sooner recovery from the symptoms of measles. Seven patients who received cimetidine had a dramatic improvement and no side effect of the drug was observed. Measles is still a serious problem in our country for undernourished infants and our try suggests that cimetidine can be used in this viral disease to shorten the course.

Cimetidine↗
PubMed1984

[Campylobacter jejuni gastroenteritis].

Acute gastroenteritis is a major cause of hospital admission with attendant morbidity and occasional mortality. Campylobacter jejuni recently has been recognized as a common cause of acute bacterial gastroenteritis in children and adults. Its frequency of isolation is comparable to and in many studies exceeds that of Salmonella isolations from diarrheal stools of hospitalized patients. Medical workers in many parts of the world confirmed that Campylobacter jejuni was found more commonly in feces in diarrheic than in non-diarrheic people. The feces is loose to watery and commonly contains blood and leukocytes. Although, Campylobacter jejuni has been isolated from feces and gallbladder of healthy and diarrheic animals, until now, to our knowledge, there is no report on the isolation of the microorganism from healthy or diarrheic subjects in Turkey. This paper reports three human infections found to have Campylobacter jejuni in their stools as part of our ongoing investigation of the incidence of diarrheal disease due to this organism.

Campylobacter fetus↗