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Biomedical subjects

E Ebner

Publications and source records attributed to E Ebner.

At least 19 recordsLinked to original sources
PubMed2006

[Transdermal buprenorphine during pregnancy].

Buprenorphine has been widely used and studied for over 20 years and has been shown to be an effective opioid analgesic. Some years ago a buprenorphine formulation for transdermal therapy of chronic cancer-related and non-cancer-related pain became available. We report the case of a woman who received a lower dosed transdermal buprenorphine patch (3/5 of a 35 microg/h patch corresponding to release of 21 microg/h buprenorphine) during pregnancy without any complication for herself or the child. The patient has now being using the transdermal system for more than 2 years and has reported continuous excellent pain relief. The buprenorphine patch was well tolerated and produced no effect on vigilance over the whole period of administration.

Administration, Cutaneous↗
PubMed1999

Influence of bolus size on efficacy of postoperative patient-controlled analgesia with piritramide.

We have examined the influence of bolus size on efficacy, opioid consumption, side effects and patient satisfaction during i.v. patient-controlled analgesia (PCA) in 60 patients (ASA I-II, aged 32-82 yr) after abdominal surgery. Patients were allocated randomly, in a double-blind manner, to receive PCA with a bolus dose of either piritramide 0.75 mg or 1.5 mg (lockout 5 min) for postoperative pain control. Mean 24 h piritramide consumption differed significantly between groups (11.4 (SD 5.8) mg vs 22.5 (18.3) mg; P = 0.001). There were no significant differences in the number of applied bolus doses, pain scores, pain relief (VAS), sedation, nausea, pruritus and patient satisfaction. We conclude that a PCA regimen with a bolus dose of piritramide 0.75 mg and a lockout time of 5 min was effective in the treatment of postoperative pain, but did not reduce the occurrence of side effects.

Adult↗
PubMed1993

Ketamine-diazepam N2O combination anesthesia--a new "circulatory-system-sparing" type of anesthetic in experimental surgery.

For studying the hemodynamics of the greater and lesser circulatory system in animals, the impact of general anesthesia upon cardiovascular functions should be as small, as possible. The marked circulation-depressing effect of halothane, which has so far been given preference for experiments on large animals, was confirmed by the present study of the miniature pig. There was a significant decrease in MAP, cardiac index and dp/dtmax/IP, and an increase in PAPp. Useful insights into hemodynamics, derived from experiments modeling the heart, lungs or vascular system cannot be gained for a cardiovascular system, the functions of which are greatly altered by such an anesthesia. As a new form of anesthesia with minimal cardiovascular influence, the ketamine-diazepam N2O combination, which has already been successfully applied in operations on the open human heart, is introduced into experimental surgery.

Anesthesia, General↗
PubMed1992

Right ventricular conductance to establish closed-loop pacing.

Innovations in pacing technology, which include the addition of rate-responsive features to programmable pacemakers, can improve the quality of life of patients suffering from sick sinus syndrome. Among the strategies providing rate-adaptive cardiac pacing, the most attractive is the physiological restoration of closed-loop chronotropic control. This paper describes how autonomic nervous system (ANS) control information is extracted from dynamic measures of myocardial contractile performance obtained from unipolar conductance measurements using the stimulation electrode in the right ventricular cavity. The pacemaker uses the ANS information to modulate pacing rate and restore normal physiological control of heart rate. A new algorithm, regional effective slope quantity (RQ), for isolating the ANS signal was developed. The resulting signal, ventricular inotropic parameter (VIP), is a normalized parameter proportional to the strength of the ANS inotropic signals to the myocardium. The efficacy of the ANS control concept was evaluated in multi-centre studies. Patients with AV block and VIP-controlled pulse generators performed defined exercise protocols. The ANS-controlled pacing rate and the spontaneous sinus rate were closely correlated. Blood pressure and subjective patient reports further indicated that good control of the cardiovascular circulation was achieved.

Autonomic Nervous System↗
PubMed1992

Autonomic nervous system controlled closed loop cardiac pacing.

A multicenter clinical study is presented, which focuses on the reestablishment of closed loop cardiac control in patients with chronotropic insufficiency. Using the information about sympathetic tone contained in the myocardial contractility, it is possible to reconnect the heart rate to the physiological control mechanisms. Intracardiac impedance is measured with the ventricular electrode and the ventricular inotropic parameter (VIP) is derived from that. The VIP serves directly as input to the control of heart rate by the pacemaker. Over 200 patients have received autonomic nervous system (ANS) controlled pacemakers. The patient-pacemaker system was investigated in different ways. This included standard exercise tests, long-term studies of every day activities over 24 hours, psychological, and pharmacological challenges. To prove the validity of the approach we specifically looked at (1) the appropriateness of changes in paced heart rate with sympathetic tone during exercise, (2) the correlation between heart rate and sinus rate, if detectable, and (3) the correlation between the echocardiographically determined preejection period (PEP) and the VIP controlled heart rate.

Autonomic Nervous System↗
PubMed1992

[Measuring intracardiac impedance for the determination of sympathetic nerve activity in frequency-adapted electrostimulation--Part 2: Clinical results].

The results of a multicenter clinical study involving patients receiving the first ANS controlled rate adaptive pacemaker are presented. In the patients with primary or secondary chronotropic insufficiency, it is possible to reestablish the closed loop control system that includes the baroreceptors, the medulla oblongata, the cardiac output and the mean arterial blood pressure. This system serves to keep the blood pressure constant in the face of changing demands on the circulation. Utilizing intracardiac impedance measurements, the myocardial contractility can be determined, which contains information about the current sympathetic tone, and thus represents an excellent physiological input for a rate adaptive mechanism. The results presented are taken from a study population of over 200 patients. The objective evaluation of this new approach was performed echocardiographically, by ergometry and 24-hour Holter monitoring.

Adult↗
PubMed1990

[Measuring place for the detection of ultra-weak photon radiation].

A measuring method for the detection of ultra-weak photon-radiation from living matter is described. Also the fluorescence-radiation is provable. The latter is of necessity for special-fluorescence investigations. A proof-sensibility of phi = 1.483 10(-16)W (respectively 7.63 10(-17)W for the distance of 65.5 mm-filter - slide replaced by trial-slide) is calculable for lambda = 554 nm with the device constant found out.

Animals↗
PubMed1989

[The hemodynamics of the lung circulation of minipigs after experimentally-caused Sedlarik's pulmonary embolism. II. Modification of the hemodynamics of the heart and circulation by thoracotomy].

The systolic, diastolic, and the mean arterial systemic blood pressure decreased after thoracotomy (by -12%). The systolic, diastolic, and the mean pulmonary arterial pressure showed an immediate decrease (by 25%). The central venous pressure was not changed. The cardiac output (HMV) and the stroke volume could not be measured before the thoracotomy. However, the HMV (+17%), the HMV-index (+30%), and the stroke volume (+60%) increased from the 10th to the 30th min after the thoracotomy. The heart rate decreased continuously (by -19%). The maximum rate of pressure rise (dp/dtmax) increased primarily insignificantly and decreased afterwards (by -10%). The quotient dp/dt/p decreased immediately (by -10%). All measures were carried out until the 30th min after thoracotomy.

Animals↗
PubMed1989

[The hemodynamics of the lung circulation of minipigs after experimentally-caused Sedlarik's pulmonary embolism. III. Sedlarik's embolization of the lung circulation by electrically-activated blood].

Pulmonary embolisms of different clinical degree of severity can be produced by means of the pulmonary embolism model according to Sedlarik by application of electrically activated blood as a thrombogenic substance. An unambiguous influence of the size and the consistency of the thrombus exists concerning the severity of the hemodynamic changes. However, the hemodynamics seems to adapt to the changed conditions of the circulation, because a tendency to normalization was observed in short-term experiments. The morphologic changes after embolisation are more typical for the severity of the clinical picture in this acute phase than the hemodynamics. A testing of the animal model in long-term experiments seem to be ingenious for that reason.

Animals↗
PubMed1989

[The hemodynamics of the lung circulation of minipigs after experimentally-caused Sedlarik's pulmonary embolism. I. Sedlarik's pulmonary embolism model in comparison to existing embolism models].

The necessity of a clinical relevant pulmonary embolism model is described because of the international importance and the consequence for certain special branches. The multifarious pathophysiologic mechanism in the human requires an approximation of the model. The pulmonary embolism model according to Sedlarik approaches these demands and it became the basis of this study.

Animals↗
PubMed1985

[Absolute arrhythmia without an initially recognizable cause--prognosis and course].

On the basis of a 10-year course examination of 21 patients with absolute arrhythmia (a. p.) should be tested whether it is justified to assume a purely functional cause of disturbances of rhythm in initially normal internal basis findings. In the period of the examinations no patient had died. Five patients showed an organic heart disease without any stronger functional effects (mitral insufficiency, coronary heart disease, hypertension, hypertrophic cardiomyopathy). In two of them complications had appeared (brain embolisms, myocardial infarction). The remaining patients were without any complaints and capable to work, apart from the intermittent or persisting disturbance of rhythm which continued to appear in all cases, and had again normal basis findings. However, in six of them echocardiographical deviations were found. In initially normal basis findings and a.p. at first a good prognosis is to be assumed. Regular control examinations are, however, necessary, that the manifestation of organic basic disease which appears among our patients in 1/4 of the cases is not overseen.

Adult↗
PubMed1985

[Transport of antibiotics to the endocardium following administration into the pericardial cavity--experimental study].

After injection of diverse antibiotics (penicillin G, tetracycline, cephalosporin) into the pericardial cavity of miniature swine higher antimicrobial activities in the subendocardial layers (mitral valve) were observed than after the intravenous application. Additional experimental studies should succeed these preliminary results. The intrapericardial application could be discussed than as a last measure in conservative treatment of the therapy-resistant endocarditis.

Absorption↗
PubMed1985

[Intrapericardial administration of drugs in the animal experiment].

Intrapericardially supplied agents for instance cardioactive drugs were transferred via lymph vessels in the myocardium likely. In case of dye application the myocardium and also the cardiac valves were coloured additionally. The effect on the heart should be more intensive and faster than after systemic application.

Animals↗
PubMed1985

[Experimental studies on the problem of improving the myocardial blood circulation in an intraoperatively resuscitated heart].

A pumping system for supporting an intraoperatively failured heart is presented. This system consists of a bell-shaped receptacle for the heart and a pump with a working volume of 49 ml and a working pressure of 220 Torr. The pumping power is transmitted to the heart by means of an external pneumatic pressure line. The efficacy of the pump in the high pressure system amounted to 20-30 per cent. An effective coronary perfusion in case of a cardiac failure is guaranteed by a venous underpressure pump of this pumping system. A favourable influence was also observed in case of the low pressure system.

Animals↗