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Biomedical subjects

E Enger

Publications and source records attributed to E Enger.

At least 19 recordsLinked to original sources
PubMed1992

[Treatment of hypertension in the elderly].

The effect of treating hypertension in the elderly (aged 60-65 years and above), and isolated systolic hypertension in particular, has not been adequately documented. In three recent studies, however, a good effect in respect of cardiovascular end points has been observed in this group of patients. We have previously suggested pharmacological treatment of a diastolic blood pressure above 100mm Hg after three to six months' observation and non-pharmacological intervention. In a patient with essential hypertension, and with no concomitant disease, systolic blood pressure should also be taken into account, and when this exceeds (100 + age) mm Hg after the same period of observation the patient should be treated pharmacologically. If a patient shows additional indications for treatment of high blood pressure, the level for initiating treatment may be lower. As of today, diuretics and beta-blockers have proven effective in reducing cardiovascular morbidity and mortality, while data on the other antihypertensive agents are still lacking.

Age Factors↗
PubMed1992

[Decision to withdraw cardiopulmonary resuscitation at Norwegian hospitals].

We present a survey on the use of do-not-resuscitate orders in Norwegian hospitals based on mailed questionnaires. 559 doctors, at least one from every somatic hospital in Norway responded. Do-not-resuscitate orders were issued by 92% of these doctors. There were large differences, however, as to who made the decision, who was involved in the decision-making, the consequences of a do-not-resuscitate order, and how the orders were documented. Formal rules for do-not-resuscitate orders are needed.

Cardiopulmonary Resuscitation↗
PubMed1992

[Use of the R-concept in a medical department].

Do-not-resuscitate orders issued in a medical department were studied by retrospective evaluation of 195 consecutive deaths in the department in 1991. No attempt at resuscitation was recorded in 171 patients. In these cases, do-not-resuscitate orders were documented in 67 only. For more than half of the orders, no reason was given in the medical record, and partial orders not to resuscitate were found in five patients only, none of whom were resuscitated. No difference was found in use of do-not-resuscitate orders between intensive-care units and regular wards, between patients above and patients below 80 years of age, or between patients with and patients without cancer. We suggest extended use of do-not-resuscitate orders in our department, and better documentation of the orders. Written guidelines have been established for this purpose.

Adult↗
PubMed1992

[Treatment of hypertension in Norway. Indications, therapeutic intensity and economic aspects].

The Norwegian Society of Hypertension held its third scientific meeting in February 1991. One of the issues discussed was when to initiate drug treatment of uncomplicated essential hypertension and what level of blood pressure should be the goal of treatment. The American guidelines suggest that a blood pressure of 140/90 mm Hg or higher should be treated pharmacologically, whereas WHO suggests 160/95 mm Hg. The consensus at the meeting was that, in otherwise healthy subjects without end organ damage, a diastolic blood pressure of 100 mm Hg or more over three to six months should be treated with drugs, and that a safe goal would be around 135-140/85-90 mm Hg.

Drug Costs↗
PubMed1992

Long term morbidity and mortality after kidney transplantation.

A cohort of 69 patients received a kidney transplant in the period 1963-1977. The mean observation time was 9.5 years. Accumulated follow-up time was 661.4 patients year. The mean (SE) 10-year survival was 55(5.9)%. Univariate analysis showed that female patients had poorer survival than male. Patients with a cadaveric donor had lower survival than those with a living donor. Also survival with different HLA-A,B match differed significantly. A multivariate analysis pinpointed nature of donor, cadaveric vs. living, as the sole independent predictor of mortality. Patients receiving a cadaveric kidney were on double (2.2) relative risk of mortality as compared to patients with a living donor. The major causes of death were infections during rejection treatment, and cardiovascular disease. Patients had low rates of morbidity. Our results showed satisfactory outcome of kidney transplantation.

Adolescent↗
PubMed1990

Effects of beta 1- and beta 2-blockade on blood pressure and sympathetic responses to flight phobia stress.

Cardiovascular and sympathoadrenal effects of short-term oral treatment with beta 1-blockade (atenolol, 50 mg, administered two times) and beta 2-blockade (ICI 118,551, 50 mg, administered three times) were compared with placebo during actual flying in subjects with flight phobia (n = 34). beta 1-Blockade lowered resting blood pressure and heart rate and prevented a heart rate response but not a blood pressure response to this psychologic stress. beta 2-Blockade minimally lowered resting heart rate and prevented a heart rate response, but it failed to lower resting blood pressure or blood pressure response to the stress. Plasma epinephrine increased with all three treatments and more with beta 1-blockade than with placebo. Plasma norepinephrine decreased with administration of beta 2-blockade. Thus neither beta 1- nor beta 2-blockade prevents an increase in blood pressure during acute flight phobia stress. Increased plasma epinephrine seems to be the sympathetic variable that is closest related to this increase in blood pressure. Norepinephrine may be less consistently related to the blood pressure rise during flight phobia stress as shown by the decrease in plasma norepinephrine with administration of beta 2-blockade.

Administration, Oral↗
PubMed1990

Correlations between psychological and physiological responses to acute flight phobia stress.

Exposure of phobic subjects to real-life psychological stress may induce a high level of anxiety and be better than laboratory experiments for studies of physiological responses to psychological stress in human research. Therefore, by introducing natural psychological stress, i.e. actual flying in subjects with flight phobia (n = 23), the present study aimed at testing the hypothesis that there is, during mental stress, a direct relationship between the level of anxiety and the responses in the physiological variables blood pressure, heart rate and plasma catecholamines. Plasma adrenaline, heart rate, blood pressure and perceived anxiety measured by three different scales increased highly significantly during flight whereas plasma noradrenaline did not change. No direct relationship was found between the physiological and psychological variables. Thus, the physiological responses to natural psychological stress in terms of phobic anxiety may be definite, but the way the responses are related is less clear.

Adult↗
PubMed1978

[Poisoning].

Explore the source record for details and available documents.

Humans↗
PubMed1978

Uromucoid in normal urine.

Uromucoid was determined in urine from persons or various ages with normal kidney function by a radial immunodiffusion technique. Uromucoid concentration was inversely correlated to diuresis. Excretion rates showed a weak correlation to body surface area in young adults of both sexes. Children had a greater excretion of uromucoid per m2 than young adults, and even newborn had a considerable excretion. Elderly subjects had similar excretion rates to young adults. Excretion rates were uninfluenced by sex, salt load or diuresis, and no difference between day and night excretion rates was observed. Intraindividual fluctuations were small, and determination of uromucoid in one single night's urine therefore gives an adequate expression of the uromucoid excretion rate.

Adolescent↗
PubMed1978

Quantification of uromucoid: a simplified method.

As a replacement of current time consuming techniques, a radial immunodiffusion method which is suitable for routine determination of uromucoid in urine in described. The method is based on denaturation of uromucoid by sodium dodecyl sulphate at 37 degrees C before application on the immunoplates. A diffusion period of 30 h at 37 degrees C was chosen. The determination is uninfluenced by variations of urinary electrolytes, freezing and thawing, and storage at 4 degrees C for 3 weeks or at -20 degrees C for several months. The method can also be applied to lyophilized urines.

Electrophoresis, Polyacrylamide Gel↗