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Biomedical subjects

E F Stranadko

Publications and source records attributed to E F Stranadko.

At least 19 recordsLinked to original sources
PubMed2001

[Photodynamic therapy of recurrent and residual oropharyngeal and laryngeal tumors].

Photodynamic therapy (PDT) was given to 61 patients with recurrent cancer of the tongue, oral mucosa, lower lip, oro- and nasopharynx, larynx. Photosensitizers photogem and photosens of Russian produce were employed. The radiation was given twice with the interval 24 and 48 hours, the exposure to light 3 to 30 min. The impact was external, through the instrumental canal of the fibroscope, by intracavitary and interstitial techniques. The response was assessed within 4-6 weeks after the PDT course. The effect was observed in 95.1% patients. Its duration ranged from 4 months to 5 years. Complete resorption of the tumor was achieved in 57.4%. The treatment failed in 4.9% patients.

Aged↗
PubMed1999

[Clinical features, diagnosis and treatment for trophic, late radiation ulcers and ulcers undergone malignant transformation].

Clinical and histological examinations of 1562 patients with trophic and advanced radiation ulcers were carried out during 30 years. Malignant transformation of the ulcers has been revealed in 14 of them: sarcoma--in 1, and cancer--in 13. From all the patients with advanced radiation ulcers, malignant transformation was detected in 7.07%, and in cases of ulcers of the other genesis--in 0.81% of cases. Malignant transformation of ulcers of non-radiation genesis occurs on the average after 19 years, and of radiation one--after 3.8 years. Early diagnosis of skin cancer, at the site of the ulceris rather difficult and depends thoroughly on oncological alert and timely morphological examination of various skin areas. A new, rather perspective and relatively simple method of treatment for ulcerative forms of cancer of the skin is photodynamic therapy (PhDT). This method showed to be effective even in those patients who failed conventional methods of treatment (relapses), or had contraindications. PhDT has broaden the armory of the oncologists and oncodermatologists for treatment of complicated forms of cancer of the skin.

Carcinoma, Squamous Cell↗
PubMed1998

Hematoporphyrin derivative or phthalocyanine photosensitized hemolysis of erythrocytes under laser irradiation.

The effect of laser irradiation on the photosensitized hemolysis of rabbit erythrocytes was investigated. Two photosensitizers of domestic production were used: Photohem (a hematoporphyrin derivative) and Photosense (sulfonated phthalocyanine aluminium). The hemolysis was activated by laser irradiation in the presence of Photohem or Photosense. The process depended on the irradiation dose, the concentration of the photosensitizers and on the time during which the erythrocytes were incubated with the photosensitizers. Three lasers with wavelengths 520, 632.8 and 850 nm were used. The photosensitized hemolysis of rabbit erythrocytes was found to be inhibited by antioxidants.

Animals↗
PubMed1994

[Photodynamic therapy and fluorescent diagnosis of malignant tumors using preparation photogem].

From February, 1992 to May, 1993 photodynamic therapy (PDT) was applied at the State Scientific Center of Laser Medicine and the Moscow Scientific-Research Oncological Institute for the treatment of 60 patients with primary and metastatic malignant tumors of the breast, skin, respiratory and digestive organs, female reproductive organs, and urinary bladder. Forty-eight patients underwent one course of PDT, 11 patients received 2 courses, and one patient was given 3 courses. Russian-produced Photogem was used as the photosensitizer. It was infused intravenously 24, 48, or 72 hours before exposure to laser beam. The dose of Photogem ranged from 2.5 to 6.0 mg/kg. The density of laser radiation power during PDT sessions ranged from 100 to 1,600 mVt/cm2, energy exposure from 80 to 600 J/cm2, duration of irradiation from 3 to 45 minutes. After treatment the patients were studied in follow-up periods of 4 weeks to 17 months. Complete regression of the tumor verified morphologically was found in 62%, partial regression in 34%, and limited response or absence of an effect in 4% of cases. Fluorescent-diagnostic examination of patients was conducted at the Moscow Scientific-Research Oncological Institute. It demonstrated the reliability of this diagnostic method with the use of the preparation Photogem as the photosensitizer.

Adult↗
PubMed1990

[Organizational principles of the outpatient examination of patients suspected of malignant tumors].

Out-patient diagnosis of cancer is carried out in three stages which involve activities of different physicians. Cancer is first suspected by a general practitioner. Prophylactic measures other than examination by specialists and chest photo-roentgenography proved insufficient, and the authors give reasons for this. During the second stage, the patient undergoes further thorough examination which should be well organized to succeed. The third stage, viz. making the final diagnosis, should be performed in an oncologic establishment only.

Humans↗
PubMed1990

[Lung cancer in women in Moscow (epidemiology, etiology and surgical treatment)].

In the studied period (1973-1987) the lung carcinoma morbidity rate among females of Moscow, in general intensive indices (per 100,000 females), showed a tendency to reduce (18.4 in 1973 and 15.1 in 1987). A reverse tendency is mostly encountered in other countries. More than half of patients with lung carcinoma were over 70 years of age. The ratio of males with lung carcinoma to that of females grew from 3.0:1.0 in 1973-1977 to 3.6:1.0 in 1983-1987. In the period from 1979 to 1988, 380 females suffering from carcinoma of the lung were hospitalized to the thoracic department of the clinic. Operations were performed on 215 of them, 174 of the operations were radical. The ratio of operated on males to females was 7.4:1.0. The frequency of central carcinoma among females was 28.8%, which was half that among males (56%). The number of operations according to volume was as follows: pulmonectomy 37, lob- and bilobectomy 119, wedge resection 18. More than half of the female patients had the glandular form of lung carcinoma and its incidence was 3-5 times that among males who were operated on (10-15%). According to the authors, the principal etiological factors are smoking, a history of another malignant tumor, and the exogenous effect of the consequences of urbanization.

Adult↗
PubMed1990

[Active screening for cancer patients].

Basic conventional methods of secondary cancer prevention are clinically reviewed. The authors hold that further extensive development of present-day organisational patterns (wider screening coverage of population, growing number of objective diagnostic techniques) shows no promise in inducing positive trends of cancer outcome statistics. Scientifically validated diminution of precancer definition is stated. Selection of population at risk for cancer and proper examination of these risk groups seem most perspective in improvement of cancer statistics.

Aged↗