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Biomedical subjects

E G Filatova

Publications and source records attributed to E G Filatova.

At least 19 recordsLinked to original sources
PubMed2006

[Use of katadolon in the treatment of abuse headache].

Katadolon (flupirtine), an analgetic with neuroprotective and myorelaxing effect, has been used in the treatment of 16 patients (15 women, 1 man, mean age 38 +/- 6 years) with abuse headache. The diagnosis has been established in accordance with International Classification of Headache Disorders, 2nd Revision (2003). All the patients had episodic headache of tension in anamnesis. Chronic pain and significant tension of pericranial muscles have been registered before the treatment. Patients abused complex analgesics, mean amount of which was 24.5 +/- 6.1 during the period of 21.25 +/- 4 days per month. Monotherapy with katadolon was administered in dosage 100 mg 3 times a day during 1 month. The treatment resulted in significant reduction of frequency, duration and intensity of headache, with a 2-fold decrease in analgesics used. The tension of pericranial muscles decreased and threshold of pain as well as that of nociceptive flexor reflex increased. There was improvement of the patients' quality of life. The period of withdrawal from drug abuse was painless. An effect of treatment remained during 1 month after the withdrawal from the drug in 11 patients, 2 patients continued to receive katadolon.

Adult↗
PubMed2005

[Efficacy of movalis in the treatment of acute low back pains].

The main aim of the study was a search for factors influencing efficacy of movalis used in combined form, injection and tablets, for the treatment of patients with acute back pain syndrome (BPS) and evaluation of the drug safety. Thirty patients, 18 female, 12 male, mean age 43.1 years, with primary BPS have been studied. In 83% of patients, BPS was caused by muscle tonic syndrome and in 17% the latter was combined with radiculopathy. Meloxicam therapy was conducted using intramuscular injections of 15 mg daily during 5 days with following oral drug intake (1 tablet daily). Treatment duration was 2 weeks. This treatment regime proved to be highly effective. The subjective meloxicam efficacy was the following: moderate--7%; good--30%; very good--33%; excellent--30%. Side effects, such as transient stomach pain, was observed only in 6.6% of patients. The main factors reducing meloxicam efficacy were affective disorders, namely, a level of depression and anxiety, and radiculopathy.

Acute Disease↗
PubMed2003

[Peculiarities of verbal activity in migraine patients].

We applied associative verbal experiment to analyze verbal activity of migraineurs. A test group consisted of 49 patients with migraine, a control one--of 20 healthy people. Reliable decrease of free associations number, verbs and plants, semantic index and changes of non-productive association index and coefficient were observed. Average depression level, higher anxiety and negative correlations with indexes calculated were found. Verbal activity of migraineurs, their ability to concentrate and to control adequateness of task fulfillment were decreased. That was caused by pain, depression, anxiety and neurotization. Verbal activity is influenced by individual emotional features (calculated indexes do not correlate with the visual analogue scale).

Adult↗
PubMed2003

[Headache caused by sexual activity].

Headache caused by sexual activity, or coital headache, is included in International headache classification (1988). The paper presents 19 cases (15 males, 4 females, mean age 34 years) examined by the authors. In 58% of the cases, headache developed before orgasm, in 26%--during orgasm and in 16%--after it. Duration of severe headache was from several to 15 min and of moderate one--up to 7 h. In total, disease lasted from 1 week to 8 years. Focal neurological symptoms were absent; magnetic resonance tomography did not reveal any changes in 68% of the patients, while the others had mild hydrocephalia. However, there was a tension of jugular, trapeziform and, less often, of temporal muscles, and, in some of the patients, an increase of arterial pressure. Among psychological features, hypochondria in men and emotional lability in women were detected. According to the clinico-pathophysiological results obtained, different pathogenetic mechanisms of coital headache were suggested: (1) disturbance of venous outflow and dysfunction of antinociceptive systems; (2) increase of arterial pressure combined with tonic tension of pericranial muscles on the background of vertebrogenic disturbances.

Adult↗
PubMed2003

[Use of acupuncture in the therapy of chronic daily headache].

To determine efficacy of acupuncture (AC) in combined treatment of chronic daily headache (CDHA), 90 patients with this disorder were studied, using clinico-neurologic tests. Severity of patient's state was evaluated with Clinical Global Impression (CGI) scale, including scoring of disease severity, global evaluation of the post treatment state dynamics and the index of therapeutic efficacy. Headache intensity was assessed with VAS. A state of functional activity of nociceptive and antinociceptive systems was studied, using nociceptive flexor reflex (NFR). For treatment, the patients were randomly divided into two clinically matched groups: group 1 received combined drug therapy, group 2--combined drug therapy and additional acupuncture course. The results revealed high efficacy of AC combined with drug therapy for CDHA treatment. Most efficient was use of AC in patients with significantly reduced activity of antinociceptive systems and presence of drug abuse allowing to reduce analgetics withdrawal time. Besides, more pronounced clinical effect of AC was obtained in patients with transformed migraine.

Acupuncture Therapy↗
PubMed2003

[Clinico-neurophysiological features of migraine with and without aura].

Clinical phenomenon of migraine aura and comparison of main types of migraine were studied, using a method of visual evoked potentials (VEP) in 46 patients with migraine with aura, in 30--without aura and in 10 healthy controls. Common features as well as differences were revealed. Patients with migraine with aura were distinguished by significantly higher mean amplitudes of P300 component and by more frequents unstable VEP registration as compared to those without aura. Qualitative changes of amplitude and configuration and reduction of latent P300 period concomitant with headache side had the same frequency in both groups. In intra-group clinico-neurophysiological analysis, in regard to visual aura phenomena, the attacks with simple phenomena were the most severe in frequency, combinations with other aura symptoms, clinical and neurophysiological signs of visual system hyperexcitability.

Adult↗
PubMed2003

[Bioelectrical activity of the brain in paroxysmal and chronic forms of primary headache].

Eighty-three patients suffering from primary headache (HA) were studied. Migraine was diagnosed in 52 (migraine with aura--8, migraine without aura--30, transformed migraine--14) and headache of tension--in 31 patients. EEG was registered before treatment, using evaluation by methods of visual and spectral analyses. The EEGs of all the patients were characterized by diffuse bioelectrical activity changes. In patients with headache of tension (episodic and chronic), the reduction of alpha rhythm with simultaneous increase of other frequency bands were the main EEG features. In migraine with- and without aura, EEGs were characterized by synchronization of alpha rhythm, its spatial redistribution and increased presentation of bilaterally synchronous alpha- and theta-activity. Comparing to EEGs in migraine with episodic attacks (migraine with- and without aura), those in transformed migraine distinguished significantly by decrease of alpha rhythm. Spectral analysis revealed an increase of spectral power of frontal regions in all forms of primary HA, a total increase of theta-band power in all forms of migraine and an increase of theta-band power in frontal regions in headache of tension. Migraine with- and without aura was characterized by reduction of alpha band power in occipito-parietal hemisphere regions.

Adult↗
PubMed2002

[Psychophysiological features of analgesics abuse headache].

Sixty patients with abuse headache (AHA) (58 women and 2 men, mean age 44.5 years) and 10 age- and sex-matched controls have been studied. AHA diagnostic criteria were as follows: daily or almost daily headache, daily or every other day use of analgesics, primary headache (migraine or headache of tension--HAT) in anamnesis, uneffectiveness of medication. Clinico-neurological analysis, headache diary, Beck depression scale, Spilberger Trait/State Inventory, "Pain lifetime anamnesis", autonomic dystonia questionnaire, evaluation of night-time sleep score subjective characteristics and nociceptive flexor reflex (R-111) (NFR) determination were used. The results obtained confirmed the literature data that analgesics abuse in migraine resulted in AHA 2 times more often than in HAT. The causes were mainly psychogenic: mood improvement, night-time sleep normalization and post-stress cephalgia intensification. An influence of such factors as age and menopause was not found. Headache was of mixed character with features of both migraine and HAT and was not dependent on cephalgia type in anamnesis. Quantity of analgesics taken by the patients ranged from 40 to 120 tablets a month and influenced, in general, a speed of primary HA to AHA transformation. For AHA formation, systematic analgesics intake was more significant comparing to its absolute quantity. Pronounced psycho-autonomic disorders and night-time sleep disturbances in AHA were revealed. In analgesics abuse, pain and NFR thresholds were significantly higher as compared to controls. However, pain to reflex thresholds ratio proved to be reduced that indicated a relative deficiency of antinociceptive system which is necessary for pain syndrome reduction.

Adult↗
PubMed2002

[Psychotherapy of patients with frequent migraine attacks].

Forty-one women (mean age 36.6 years) with migraine without aura were studied and psychotherapeutic preventive treatment was conducted. Attack frequency was 5.8 a month, attack duration--29.5 h, intensity on visual analogue scale--8.2 scores. Clinical effect of the psychotherapeutic method was evaluated using clinico-neurological, experimental psychological and electrophysiological testing. During the treatment course, the patients self-rated the frequency, intensity, duration and characteristics of attacks and quantity of medications in a diary. A battery of psychological tests included Beck and Hamilton scale, Spilberger Inventory, Bass-Darky, Ammon, Plutcheck, Munstenberg tests and coping strategy in stress. Neurophysiological study was conducted using contingent negative deviation (CND) pre- and after treatment. Psychotherapeutic treatment was aimed at identification of patient's usual reaction style, kind of interrelations with other people, education, presence of psychotraumatic situations, reaction to disease and treatment. Several factors contribute to migraine severity: presence of deficit aggression in the form of autoaggression, personality features discrepancy, unconscious desire to be ill, passive pain coping strategies resulting in strengthening pain sensations and emotional disorders aggravation, tension of psychological defense, indicating psychological maladaptation, prevalence of unproductive mechanisms. The psychological peculiarities identified in the patients were subjected to psycho correction. An improvement of clinical (reduction of attack frequency and duration, pain relief) and psychoautonomic indices as well as electric brain activity normalization (decrease of early CND wave) were achieved. Correlation analysis of treatment efficacy confirmed, in general, the right choice of psycho-correction targets.

Adaptation, Psychological↗
PubMed2002

[A pathogenesis of post-stroke depression].

Thirty-one patients (17 males and 14 females aged 30-74 years, mean age 61 years) with depression were examined 3-6 months after ischemic stroke. Control group included 10 sex- and age-matched healthy subjects. Neurological, psychological and psychometric tests (the Hamilton, Beck, Spilberger, mini mental scales and Quality of Life questionnaire) were conducted. A mean depression level in patients with stroke did not differ from that in the controls and did not depend on lesion size, location, neurological deficit degree. Clinically pronounced, i.e. relatively severe, post-stroke depression was detected in 22% of the patients and its severity was higher in cases of right-hemisphere stroke. Psychosocial factors were found to be the most significant in post-stroke depression. Depression occurred more often in patients, who were single, in women, in preserved intelligence and higher level of personality anxiety. Loss of job as a result of the vascular disaster proved to be not a very important psycho-traumatizing factor in the group studied.

Adult↗
PubMed2000

[Therapy of autonomic disorders by xanax (alprazolam)].

The paper presents an open noncomparative investigation of 36 patients with different manifestations of the syndrome of autonomic dystonia. 20 patients (group 1) had permanent autonomic disorder in context of generalyzed anxious disorders, 16 patients (group 2) had panic attacks. The examination was performed before and 4 weeks after monotherapy with xanax (1.5-2.5 mg/day). Clinical-neurologic study estimated both presence and a degree of manifestations of the syndrome of autonomic dysfunction, hyperventilatory syndrome and sleep disorders. Psychologic investigation included estimation of anxiety according to Spilberg's test, depression according to Beck's scale; SCL Scale was also used. Algesic syndrome was estimated by complex algesic questionnaire. Neurophysiologic study determined a contingent negative deviation and nociceptive flexory reflex. A positive therapeutic activity of xanax was established. The highest therapeutic effect was achieved in group 1 (83%) using lower doses (1.5 mg/day). In group 2 higher doses were needed (2.5 mg/day). In this case the effect was achieved in 83% of the cases, but full absence of panic attacks was observed only in 25% of the patients. Predictors of the drug's efficiency appeared to be short duration of the disease, slight manifestation of depression and absence of the algesic syndrome.

Adult↗
PubMed2000

[Psychological factors of chronic pain].

To investigate psychological factors, involved in formation of chronic algesic syndrome, 70 patients (50 women, 20 men, mean age--33.5 years) with panic disorder (PD) were examined. The patients were divided into 3 groups: with PD combined with chronic ache (CA) (26 patients); with PD combined with episodical ache (EA) (19 cases); PD without ache (25 individuals). Algesic phenomena were estimated according to "Algesic anamnesis of life" questionnaire; depression level was estimated according to Back's and Hamilton's Rating tests; the level of reactive and personality anxiety--according to Spilberger's inventory test. Severity of psychopathologic syndromes was estimated according to SCL Rating Scale. It was demonstrated that patients with CA and PD have a more significant role of depression in course of the disease as compared with anxiety; prevalence of functional-neurological symptoms in clinical pattern of PD (atypicalness); high level of somatization and a lot of algesic stresses in their life. Factors that prevent chronization of the ache were the following ones: degree of manifestation and the significance of phobic anxiety in the course of the disease, restricting behavior, atypical PD and less number of pain episodes in life.

Adult↗
PubMed1999

[Algesic phenomena in panic disorders].

There were examined 35 patients with panic disorders (PD) which were divided into 2 groups. In patients of the 1-st group there were observed headaches of tension type (17 individuals), meanwhile in the patients of the 2-nd group (18 cases) there weren't observed any algesic syndromes. A "saturation" of the life of a patient with the different algesic phenomena were estimated as well as the level of a depression according to Beck's scale and the manifestations of psychopathologic symptoms according to SCL scale were also studied. To estimate neurophysiologic parameters there were used a method of a contingent negative deviation (CND) and nociceptive flexor reflex. For the patients of the 1-st group there was quite characteristic a "saturation" of life with algesic events, an atypicity of the algesic attacks and more pronounced connection of PD debut with biologic but not with emotional factors. Psychometric observation revealed a significantly higher levels of both the depression according to Beck's and the somatization according to SCL scales as compared with the 2-nd group. Alterations in CND parameters (a decrease of the amplitude of the late wave, increase of postimperative negative wave) and an increase of a subjective algesic perception in the patients of the 1-st group had testified the pronounced desadaptive disorders. In the patients of the 2-nd group these indices were normal. Thus, on the PD model there were studied some psychophysiologic factors, which caused a formation of chronic algesic syndromes in the patients.

Adult↗
PubMed1997

[The treatment of tension headache with sirdalud].

For the first time sirdalud was used in the treatment of 32 patients with chronic form of tension-type headache. The preparation was applied during 14 days (4 or 6 mg daily). Positive effect was observed in 75% of patients (a decrease of both headache and tension of pericranial muscles). However, sirdalud was so effective neither in patients with pronounced depression nor in ones without pericranial muscular tension. The drug had a number of psychotropic effects: it decreased anxious-depressive manifestations, normalized night sleep, significantly increased the thresholds of both ache and nociceptive flexor reflex.

Adult↗