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Biomedical subjects

E Gafiţanu

Publications and source records attributed to E Gafiţanu.

At least 19 recordsLinked to original sources
PubMedDate not supplied

[Antimicrobial activities of organic zinc compounds].

Taking into account the competitive action of zinc towards other ion essential for pathogenic germs metabolism, the complex erythromycin-zinc, zinc salts of sulfamethoxydiazine, sulfanilamide, sulfacetimide, sulfathiazole as well as the Mannich basis of sulfamethoxydiazine were synthetized. The antimicrobial action towards gram-positive, gram-negative pathogens and fungi was tested by the classic diffusiometric method. An increased antimicrobial action for the Mannich basis of sulfamethoxydiazine and for the zinc salt of sulfamethoxydiazine, alone or in association with metronidazole--chemotherapeutic agent used in the infections with anaerobic organisms was found. A significant antimicrobial action was also found for the complex erythromycin-zinc and zinc salts of sulfacetimide and sulfathiazole.

Anti-Bacterial Agents↗
PubMedDate not supplied

[Formulations and bioavailability of propyphenazone in lyophilized tablets].

The present work reports some facts about the preparation and release characteristics of the tablets of propiphenazone made by lyophilizing method (lyoc); they are compared with the classic tablets obtained by simple compression. Our substance, the propiphenazone, is a stable one, but we can talk about its poor solubility. Therefore, in order to obtain the lyoc tablets, we chose the method of paste. This tablets had a spongy aspect, with a desaggregation time of 1-2 min.; the latter (classic tablets) were regularly and the desaggregation time in about 9 min. The kinetics of propiphenazone absorbtion would be expected to differ in these structurally-distinct tablets types. Indeed, the concentration was really appreciable for the lyoc tablets after 30 min., with the peak at 60 min.; for the classic tablets the peak was remarkably only after 90 min. The relative bioavailability for these two types of tablets pointed out the differences, confirming the evident advantages for using the lyoc tablets in analgesic, antipyretic therapy.

Anti-Inflammatory Agents, Non-Steroidal↗
PubMedDate not supplied

[The effect of a hydrogel with Enzaprost F on labor induction in pregnant women with severe late gestosis].

The authors suggested a new method for preparing the delivery in patients with severe gestosis consisting of local applications of Enzaprost F hydrogel in association with the correction of arterial hypertension in relation with the hemodynamic type. Unlike the previous preparations, in the composition of the hydrogel with prostaglandin F2-alpha, polyvinylpyrrolidone is also included, thus increased adhesive properties and a slower release of prostaglandin resulting. The correction of arterial hypertension depending on the hemodynamic type provided rapid stabilization of patients' condition. The suggested method does not only decrease by 2.4 times the prenatal hospitalization but also reduces with 16.2% the frequency of abdominal delivery in this category of patients.

Adult↗
PubMedDate not supplied

[Adhesive cutaneous pharmaceutical forms].

The adhesive cutaneous pharmaceutical forms aimed to local action release the drug substance in view of a dermatological, traumatological, antirheumatic, cosmetic action. Two such preparations were obtained and their stability, consistency and pH were determined. The "in vitro" tests of their bioavailability revealed the dynamics of calcium ions release according to the associations of each preparation. The bioavailability determined by evaluating the pharmacological response demonstrated the antiinflammatory action obtained by the association of calcium ions with the components extracted from poplar muds. The therapeutical efficiency of the studied preparations has proved in the treatment of some sport injuries.

Adhesives↗
PubMedDate not supplied

[The cutaneous bioavailability of alpha-chymotrypsin from ointments].

In view of improving the cutaneous bioavailability of alpha-chymotrypsin from ointments, the stability of this enzyme in two hydrophile ointment bases, macrogoli and carbopol, was tested. The cutaneous bioavailability of alpha-chymotrypsin in ointments, estimated by determining the anti-inflammatory action, underlines the important role played both by the ointment base and by the enzyme activating substances. By correlating the determinations of alpha-chymotrypsin enzymatic activity with the anti-inflammatory action a correlation between the manifested activity and the active substance stability was noticed.

Animals↗