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Biomedical subjects

E Grossmann

Publications and source records attributed to E Grossmann.

At least 19 recordsLinked to original sources
PubMed2006

[Case report: Libyostrongylus douglassii-associated proventriculitis in ostriches in Germany].

Cases of Libyostrongylus douglassii-associated proventriculitis in an adult female ostrich and two ostrich chicks occurring on two farms in different federal states of Germany are described. The adult bird was recently bought and kept under quarantaine conditions without contact to other animals of the herd. Without developing clinical signs of illness, the animal died. At necropsy, typical lesions of wireworm infection were found. The lining of the stomach had a moth-eaten appearance. Massive amounts of adult stages of trichostrongyloid nematodes were diagnosed in histological specimens of the proventricular mucosa and under the koilin layer of the ventriculus. The worms were isolated from the proventriculus and identified as L. douglassii. The feces of the bird contained high amounts of typical eggs of the worms with a medium size of approximately 70 x 40 microm. A polyphasic degeneration of heart and skeletal muscle was diagnosed in addition to the wireworm infection and interpreted to be a result of a malnutrition (Vit. E-/selenium deficiency). The ostrich chicks were reared on another farm and submitted for necropsy because of high mortality (8 out of 12 chicks died). A massive invasion of the proventricular mucosa with L. douglassi was macroscopically and histologically detected at necropsy of the anemic birds.

Animals↗
PubMed2002

[Chlamydial diseases of domestic animals--zoonotic potential of the agents and diagnostic issues].

The role of chlamydiae as agents of a number of important animal and human diseases is still the subject of intensive research. Recently, a proposal for taxonomic reclassification of this group of obligate intracellular bacteria was published, which was based on a large amount of new data on genetic relatedness. According to this proposal, the family Chlamydiaceae now comprises two genera (Chlamydia and Chlamydophila) with 9 largely host-related species. The previously accepted classification scheme had distinguished 4 species within the genus Chlamydia. The most important animal chlamydiosis with zoonotic character is psittacosis, a systemic disease in psittacine birds of acute, protracted, chronic or subclinical manifestation. The analogous infection in domestic and wild fowl is known as ornithosis. Avian strains of C. psittaci (new classification: Chlamydophila psittaci) can also infect humans, the symptoms being mainly unspecific and influenza-like, but severe pneumonia, endocarditis and encephalitis are also known. The main group of persons facing an elevated risk of infection includes those having frequent contact with domestic and companion birds at work or in their spare time. In Germany, the annual average of notified cases is approximately 100. Cases of transmission to humans were repeatedly reported in connection with enzootic abortion in sheep (causative agent: C. psittaci or Chlamydophila abortus, respectively). Various chlamydial species occur as pathogens and commensals as well in cattle, pigs, horses, and cats. The assessment of the actual epidemiological importance is, however, often difficult because of their almost ubiquitous spread. Likewise, those strains of C. pneumoniae (new classification: Chlamydophila pneumoniae) found in several animal species can not yet be assessed for pathogenic properties. The possibilities for diagnostic detection of chlamydiae have considerably improved following the introduction of molecular methods, particularly the polymerase chain reaction (PCR), which permits direct identification from clinical specimens and differentiation of species.

Animals↗
PubMed2001

Genetic characterization of a Chlamydophila pneumoniae isolate from an African frog and comparison to currently accepted biovars.

The amphibian isolate DE177 identified as Chlamydophila (C.) pneumoniae was sequenced in five genomic regions: 16S ribosomal RNA gene, 16-23S intergenic spacer, ompA, ompB, and groESL genes. Comparison with corresponding sequences of the currently accepted equine, human and koala biovars of C. pneumoniae revealed that koala strains represented the most closely related taxon, although sequence dissimilarities in the ompA (VD4) and ompB gene regions were noted. In this respect, the present isolate is distinct from a previously described frog isolate (Berger et al., 1999) whose sequence analysis yielded identity to the koala biovar. As three of the nucleotide substitutions in ompA (VD4) of DE177 will be translated into two altered amino acids the possible existence of another biovar is discussed.

Amino Acid Sequence↗
PubMed1998

Eagle's syndrome: a case report.

The authors analyzed, through a review of the literature, Eagle's Syndrome which is a complex entity which presents common symptoms varying from an aching sensation in the throat to dysphagia and pain when rotating the head. Diagnosis and treatment are the main topics discussed relative to this abnormality which involves the styloid/stylohyoid complex. A case report is presented of a woman, aged 52, who submitted to surgical treatment using an extraoral approach for removal of the elongated styloid process to illustrate and facilitate the explanation of Eagle's Syndrome, including its manifestations and proper treatment.

Facial Pain↗
PubMed1998

[Protein patterns of Pasteurella multocida strains in relation to the animal host and the geographic site of isolation].

Protein patterns from 681 Pasteurella multocida strains of different animal species and distinct geographical regions were analyzed by PAGE. We found 9 protein types taking the most intense band as reference. This band represents a protein of the outer membrane (OMP). In assigning the strains to protein types a relation to animal hosts of the strains was established. The majority of isolates from rabbits (88%) belongs to type P6, which is not found in strains isolated from cattle or pigs. Strains from pigs did not include the protein types P2, P4 and P8, in cattle strains type P9 was absent. The distribution of protein types in bovine isolates was shown to be related to the geographical location. The results are discussed with particular emphasis on immuno-prophylaxis. It appears promising to develop P. m. vaccines specific for certain animal species.

Animals↗
PubMed1996

Decreased bone mineral density in patients with pustulosis palmaris et plantaris.

BACKGROUND: Focal skeletal changes in patients with pustulosis palmaris et plantaris (PPP) are known to occur in a minority of patients. It is unknown whether these changes are unique events or whether they merely represent more progressed cases. OBJECTIVE: The study was undertaken in order to investigate possible diffuse bone changes in patients with PPP. METHODS: Bone mineral density (BMD) and biochemical markers of bone turnover were studied in 18 female patients and 18 age-matched controls. RESULTS: A significant correlation was found between lower-forearm BMD and disease duration (< 0.05). With increasing age, patients had significantly lower values than controls for both forearm and spine BMD (p < 0.005); patients who had PPP for more than 2 years had significantly reduced forearm BMD (19.8%; 95% CI: 5.6-32.8%) and spine BMD (17.4%; 95% CI: 0.9-33.8%). No significant differences were observed in biochemical markers of bone turnover, physical activity or body mass index between patients and controls. The proportion of smokers among patients was four times higher than among controls (p < 0.0005). No significant dose effect was found between number of pack-years and BMD. CONCLUSION: Although we cannot exclude that prolonged use of topical steroids under occlusion is a confounding factor, the study suggests that PPP patients have decreased BMD due to primary pathogenic events, and that osteoporosis may be an additional problem for these patients.

Adult↗
PubMed1996

Polycystic liver disease, complicated by Salmonella infection.

BACKGROUND: Polycystic liver disease is a relatively uncommon congenital condition. Infections of these cysts do occur, but there are no reports of salmonella as the aetiologic agent. Salmonellosis, complicating hydatid disease of the liver has been described. CASE: A patient with a long-standing polycystic liver disease suddenly developed an infection of one of the cysts, caused by Salmonella javiana. Under sonographic guidance a percutaneous drain was inserted into the cyst, followed by systemic antibiotic treatment and, later, intracystic instillation of tetracycline. CONCLUSION: The sclerosing treatment was successful, thus preventing laparotomy.

Aged↗
PubMed1995

[Post-traumatic pseudoaneurysm of the posterior tibial artery].

A case of post-traumatic pseudoaneurysm of the posterior tibial artery is presented. The diagnosis was made by ultrasound one week after the trauma, and a vascular reconstruction was performed. The purpose of this case report is to bring attention to this complication to vascular trauma, which may cause delayed symptoms long time after the injury. We suggest that these patients should be treated with vascular reconstruction rather than ligation, thereby preserving the function of this artery.

Adult↗
PubMed1995

Structure and composition of the rodent lamina cribrosa.

To define the architecture and extracellular matrix composition of the lamina cribrosa in rodents, normal, adult pigmented rat and guinea pig eyes were frozen and sectioned for light microscopic immunohistochemistry. Antibodies specific for collagens I, III, IV and VI, laminin, elastin, and chondroitin and dermatan sulfate proteoglycans were exposed to longitudinal and cross-sections of optic nerve heads and their binding distributions observed with the avidin-biotin-peroxidase complex technique. Cross-sections of the intraocular portion of the rat optic nerve head revealed a horizontally oval shape with distinct, vertically oriented, laminar beams. The guinea pig optic nervehead cross-section was circular, with randomly oriented beams. In both animals, collagens I, III and VI were found throughout the laminar beams, along with elastin fibrils. Collagen IV and laminin antibodies deposited along laminar beam margins and within the beams, representing astrocytic and vascular endothelial cell basement membranes. Both animals showed evidence for dermatan and chondroitin sulfate-containing proteoglycans in all connective tissue structures of the nerve head. In the rat, chondroitin-4 sulfate proteoglycans appeared localized to the sclera and laminar beams. The rat and the guinea pig optic nerve head possess an identifiable lamina cribrosa with structural proteins nearly identical to that of the primate. Both animals may provide affordable alternative animal models for in vivo studies on the role of the lamina cribrosa in glaucomatous optic nerve damage.

Animals↗
PubMed1994

[Radiological findings in patients with a J-shaped ileal reservoir].

This study comprised 116 patients with either ulcerative colitis or familial adenomatous polyposis, who were treated from 1983 to 1990. The patients were subjected to total colectomy followed by formation of an ileoanal reservoir (J-pouch). In a retrospective study the radiological findings of the J-pouch and the reservoir related complications are presented and a description of the applied technique for pouchography is given. A total of 513 radiological investigations were performed--median two per patient (range: 1-44). All 116 patients were subjected to pouchography while 59 patients additionally underwent conventional X-ray investigations, 42 patients were referred to ultrasound and ten patients to CT. Fourty-five percent of the patients presented no radiological complications at all. Patients with a normal primary pouchogram showed a significantly lower risk of long term complications related to the pouch. Pouchography was a useful method for excluding pouch pathology before restoring intestinal continuity as well as showing fistulas or cavities. In cases of leakage and especially stenosis and pouchitis pouchography was, however, less reliable. Ultrasound examination combined with CT-scan was beneficial in diagnosing abscesses.

Adenomatous Polyposis Coli↗
PubMed1994

Benzodiazepines influence melatonin secretion of the pineal organ of the trout in vitro.

The effect of benzodiazepines (BZP) on melatonin release was investigated in the pineal gland of the rainbow trout, Oncorhynchus mykiss, maintained under in vitro perifusion culture conditions. Melatonin and the methoxyindoles 5-methoxytryptophol (5-MTOL), 5-methoxyindoleacetic acid (5-MIAA), and 5-methoxytryptamine (5-MT) were determined directly in samples of the superfusion medium by HPLC with electrochemical detection. Melatonin release was significantly increased by addition of diazepam and clonazepam in a dose-related and reversible manner. The effects of benzodiazepines were more pronounced in light-adapted pineal organs, when melatonin secretion is low, than under scotopic conditions. When the perifusion medium was replaced by a medium containing low calcium, high magnesium concentrations, melatonin release was considerably decreased by 70% in light-adapted and 20% in dark-adapted pineal organs. Addition of diazepam to low Ca2+, high Mg(2+)-medium reversed the decrease of melatonin release and produced a clear rise in its secretion rate. Addition of the BZP antagonist flumazenil to the perifusion medium slightly decreased melatonin release in the light- and dark-adapted state, whereas the peripheral receptor antagonist PK 11195 did not alter melatonin release. The effect of diazepam is reduced by simultaneous addition of flumazenil to the superfusion medium, suggesting that the effects of diazepam are receptor-mediated. The methoxyindoles 5-MTOL, 5-MIAA, and 5-MT showed no significant changes of their release pattern after diazepam application in light- and dark-adapted pineal organs. These results suggest that BZP can influence melatonin production and release by an intrapineal action possibly on the melatonin synthesizing photoreceptor cell.

5-Methoxytryptamine↗
PubMed1994

Deformity after internal fixation of fracture separation of the medial epicondyle of the humerus.

We reviewed 24 displaced fractures through the physis of the medial epicondyle of the distal humerus. One was a Salter-Harris type-II fracture-separation of the whole distal humeral epiphysis; the others involved only the medial epicondylar centre of ossification. Two cases had presented as pseudarthroses. One fracture had been treated closed in a plaster slab and 21 had had open reduction and internal fixation with sutures, Kirschner wires or Palmer nails. At 2 to 13 years later we found five types of deformity of the epicondyle: pseudarthrosis, an ulnar sulcus, a double-contoured epicondyle, hypoplasia or hyperplasia. Pseudarthrosis had developed after either no treatment, closed reduction and plaster, or open reduction and suturing. Hypoplasia followed nailing, as did a trend to varus tilting of the joint surface. One very young patient, with fracture-separation of the whole distal epiphysis treated by nailing, developed marked cubitus varus.

Adolescent↗
PubMed1990

[Emergency ultrasonic examinations].

The employment and yields of emergency examinations carried out outside normal working hours in Bispebjerg Hospital, Copenhagen, in 1987 are illustrated. This facility is employed particularly by surgical departments for examination of patients with acute abdominal and retroperitoneal conditions and it is frequently supplemented by immediate ultrasonically guided drainage. The possibility of emergency examinations contributed to rapid, certain and gentle diagnosis in the treatment of patients.

Abdomen, Acute↗
PubMed1990

[Candidiasis of the stomach as a complication of hiatal hernia surgery].

Candidiasis in the stomach after hiatus hernia sac operation has not previously been reported in the literature. We present a case in which a 46 year old woman developed candidiasis of the stomach, two months after hiatus hernia sac operation. The disease was primarily diagnosed radiologically and was later confirmed by gastroscopy and culture of gastric fluid. The pentagastrin test was performed six months after the operation and showed significantly reduced acid production. The most probable explanation for the condition is peroperative accidental lesion of branches of the vagus nerve resulting in reduced acid production thus facilitating growth of gastric candidiasis.

Candidiasis↗
PubMed1990

Ultrasonically guided percutaneous nephrostomy.

Ultrasonically guided percutaneous nephrostomy was planned in 98 patients with a total of 128 nephrostomies. The success rate was over 90%. The catheters were maintained from a 1/2 day to 150 days with a median duration of 13 days. 26% of the patients had the catheter replaced, mainly because of displacement. Two major complications were seen, one perforation of the gallbladder and one case of major haemorrhage resulting in a nephrectomy. Two of the 26 patients infected at the puncture died from sepsis. Among cases with low ureteral obstruction untreated prostatic carcinoma and ureteral tumors were the two only categories in which a palliative nephrostomy was beneficial.

Adult↗