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Biomedical subjects

E Grossmann

Publications and source records attributed to E Grossmann.

27 records · Page 2Linked to original sources
PubMed1987

[Early sonographic recognition of renal cell carcinoma].

Of 19 patients with renal cell carcinoma diagnosed by ultrasound, nine already had symptoms of the tumor at the time; in the other ten it was discovered by chance during an upper-abdominal ultrasound screening. The latter group differed from the former by a lower average age (52.7 compared with 63.1 years), lower mean tumor size (4.5 and 7.0 cm, respectively), less advanced tumor stage, further course with fewer complications, and higher survival rate. The findings underline the great importance of routine abdominal ultrasound screening in the early diagnosis of tumors.

Carcinoma, Renal Cell↗
PubMed1986

[Thyrotropin-displacing antibodies in thyroid gland diseases].

Thyroid-stimulating antibodies were assayed in 798 patients with thyroid diseases and 122 controls by means of a heterologous radioreceptor assay as thyrotropin displacement activity (TDA). With an intraassay variance of 5-6% and an interassay variance of 8-13% in higher TDA values, test results were well reproducible. Thus, TDA assay is suitable for routine testing and follow-up of titers in the upper range. With only few exceptions TDA values of F greater than or equal to 11% are found exclusively in Graves' disease (sensitivity 39.2%; specificity vs other thyroid diseases 99.7%). In patients with functional autonomy in nodular goitre (Plummer's disease) TDA is consistently negative. TDA measurement is a valuable means for the detection of Graves' disease and for differential diagnosis of hyperthyroidism of undetermined pathogenesis.

Antibodies↗
PubMed1986

New compounds with cytotoxic and antitumor effects. Part 6: Monomeric indole alkaloids of vinca minor L. and their effect on P388 cells.

Vincaminorine and vincaminoreine, the monomeric indole alkaloids, belonging to the respective quebrachamine skeletal types, and vincadifformine of the aspidospermine group were those of 15 bases examined found to exhibit a considerable inhibition effect on the P388 cells. The above-mentioned secondary metabolites inhibited the synthesis of nucleic acids and proteins. Vincadifformine, which was found to inhibit most significantly the biochemical functions of P388 cells of all monomers under study, stopped the proliferation of cells in vitro in a 50 micrograms X ml-1 concentration even after 12 h of action. The effect of vincadifformine was greater than that of vinblastine, which was evaluated under the same conditions on the P388 cells in vitro.

Animals↗
PubMed1984

Long acting nifedipine in the treatment of severe hypertension.

The medication of patients receiving hydralazine, captopril and minoxidil was replaced by a new galenical form, long-acting nifedipine. An additional decrease in blood pressure was observed in most of the patients. Renal function was maintained in all of them. Adverse reactions may be reduced by the use of long-acting nifedipine, which would permit a reduction in the dosage of captopril and minoxidil.

Adult↗