Biomedical subjects
Publications and source records attributed to E I Tkachenko.
The article is a review of data, revealing scientifically proven approaches to correction of human microbiocenosis disturbances with the help of microbe probiotics, produced on the basis of synergic components and properties of B. subtilis culture 3.
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This article describes the role of the intestinal microbiocenosis in the development of metabolic, immunologic, morphologic disorders of the gastrointestinal tract as well as mechanisms of the association of the intestinal endoecology and bacterial metabolites with the mental status, intellectual characteristics and social functions of people.
We examined 50 children at the age of 4-17 suffering from chronic gastritis. AntiH+/K+-ATPhase antibodies of gastric parietal cells, anti-EBV antibodies IgG EA and IgM VCA were determined with the help of immune-enzyme analysis methods. The first group comprised 28 children with a high level of antiparietal antibodies in the blood serum, and 22 children with a normal level of antiparietal antibodies made up the second group. The HP identification was carried out for all children. Anti-EBV antibodies IgG EA were found in 72% of children, and there were no statistical differences in the frequency and level of antibodies IgG EA. IgM VCA were not found in any of the patients. However, HP-infection was revealed in 64.3% in the first group vs. 22.7% in the second group (p < 0,05); the combination of HB and chronic EBV infection was also more frequent in the first group than in the second group (42.8% and 18.1%, respectively, p < 0,05).
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54 children at the age of 3-15 suffering from HP-associated CG were examined. Antibodies to H+/K(+)-ATPase of gastric parietal cells were determined with the help of the immune-enzyme analysis method. It was discovered that antibodies to H+/K(+)-ATPase are found in 27.7% of children. Concomitant autoimmune diseases, pangastritis, morphologic symptoms of the pre-atrophic stage of autoimmune gastritis as well as the drop of secretion at the fasting phase were discovered more often in antibody-positive patients. The successful eradication of HP in two children resulted in the disappearance of anti-parietal autoantibodies.
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We examined: 1 group--16 children with chronic gastritis (CG) and autoimmune thyroiditis (AT); 2 group--41 children with functional thyroidal pathologies; 3 group--23 children with CG only. The average age in all groups was 11.17 +/- 2.98. HP (68%) was revealed equally frequently in all the groups. Antibodies to H+/K(+)-ATPase of parietal cells were revealed in the first and second groups only (31-36%), p < 0.05 as compared to the third group. CG of the stomach body was more frequently revealed in the first group using endoscopic and histological tests. The second group had more frequent and more apparent lesions of the antral part. Thus, in case of concomitant diseases of the thyroid gland CG has an autoimmune nature of an inflammation of the mucous coat of the stomach.
In February 2002 the XXIX Scientific Session of the Central Research Institute on Gastroenterology was spent, where in the frames of the Round table some problems of the Syndrome of irritable intestine were discussed.
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The paper shows it necessary to define clinical physiology of the digestive system as a nosological entity due to the natural evolution of physiology and to the increasing clinical practical requirements. It considers its purpose, tasks, and areas under study and gives the results of some original studies of the gastroduodenal and hepatobiliary systems and the small intestine. Special emphasis is laid on new guidelines to examining the functional and morphological states of the alimentary tract.
The examination of 453 new cases of young-age gastroduodenal affections demonstrates that two-thirds of the patients have non-ulcerative dyspepsia presenting as a symptom complex associated with heterogeneous group of gastric and duodenal diseases with specific pathomorphological alterations in the absence of ulcers and cancer. The problem of nonulcerative dyspepsia needs further detailed specification studies.
The health of a man considerably depends on his nutritional status. The present-day defects in dietary are frequently acting as the main "killers" and "pathogens" in the modern human society. The poor dietary could considerably change the protective status of a human organism and influence upon the course of diseases. The article makes a definition of the "trophological status" and describes various methods of its estimation which could be successfully applied for an early diagnosis of trophological insufficiency in servicemen.
Clinico-statistical evaluation of reparative process in 332 gastric ulcer and 294 duodenal ulcer patients revealed factors of objective value to its course. In order of significance the factors rank as follows: area of ulcer, localization, combination with certain mucosal erosions, total fasting acidity, free fasting hydrochloric acid, basal gastric secretion, cardial function, duodenogastric reflux, sex, age, number of cigarettes smoked daily. When studying treatment effects on regeneration in ulcer patients in is necessary to take into consideration basal clinico-endoscopic parameters.
Two groups of pathogenetic mucosal changes peculiar to fasting period were revealed in 28 obese patients: a structural rearrangement of mucosa with inhibition of mitotic activity of epithelial crypts, and the inflammatory responses manifested by increased cellular infiltration of stroma and compensatory-adaptive changes of capillary bed structures. The adequate dietotherapy provided full recovery of the mucosa tissue parameters on the 26th day.
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