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Biomedical subjects

E I Tkachenko

Publications and source records attributed to E I Tkachenko.

At least 37 records · Page 2Linked to original sources
PubMed1992

[Diagnosis of trophologic insufficiency].

Nutrition is a very important factor in maintenance of human health. Defects in nutrition may become the main "killer" and "pathogen" in current human society. Malnutrition can modify host defenses, influence the disease patterns and outcomes. The paper introduces the notion "trophologic status" as an indicator of human health. The definition is presented. Assessment of the trophologic status can be conducted by various methods useful for different medical institutions in early diagnosis of trophologic insufficiency in patients.

Diagnosis, Differential↗
PubMed1991

[The specificity of the peripheral blood changes in patients with gastric peptic ulcer].

Leucocytes were studied in 112 patients with ulcer disease of the stomach in comparison with periods of existence of an ulcer defect of the gastric mucosa. Methods of statistical analysis allowed to establish that the peripheral blood shows phasic changes in the absolute content of the leucocytes and their forms, pathogenetically related to the course of the reparative process.

Adult↗
PubMed1989

[A comparative evaluation of the efficacy of sucralfate and H2-histamine blockaders in treating peptic ulcer].

Sucralfate (55 patients), cimetidine (25 patients), ranitidine (30 patients), antacids and cholinolytics (32 patients) were studied and compared in open clinical trials for the efficacy in the treatment of ulcer disease of the stomach and duodenum. During 5 weeks, ulcers completely healed in 100% of the patients given sucralfate (in 94.5% for 4 weeks), in 90% of the patients treated with ranitidine, in 84% on cimetidine, and in 78% of the patients undergoing treatment with antacids and cholinolytics.

Adolescent↗
PubMed1988

[Effect of M and N-cholinoblockers on the excitability of the dorsal hippocampus in acute alcoholic intoxication].

It has been established in chronic experiments on rabbits that acute alcohol intoxication increased the after-discharge thresholds in response to electrical stimulation of dorsal hippocampus. It has been shown that neurotropic agents selectively blocking M- or N-cholinoceptors exerted various effects. M-cholino-blocker methamizol (1 mg/kg, i. p.) decreased the excitability of dorsal hippocampus, potentiated EEG and behavioural effects of alcohol intoxication. N-cholinoblocker etherophen (IEM-506, 20 mg/kg, i. p.), on the contrary, increased the excitability of dorsal hippocampus and reduced behavioural effects of alcohol administration.

Alcoholic Intoxication↗
PubMed1986

[Effect of N- and M-cholinergic-potentiating and cholinergic-blocking agents on the epileptogenesis of a penicillin focus in the dorsal hippocampus].

Chronic experiments on rabbits with penicillin epilepsy have shown that intravenous injections of the ACHE inhibitor galanthamine (1 mg/kg), and N-cholinergic-blockers, ganglerone (3 mg/kg) and eterofen (8 mg/kg), decreased or suppressed completely epileptogenesis manifestations. Combination of galanthamine with one of the N-cholinergic-blockers markedly increased their anticonvulsive actions. On the contrary, combination of galanthamine with the M-cholinergic-blocker metamizil (0.5 mg/kg) enhanced epileptogenesis activity. It is postulated that both M- and N-cholinergic mechanisms take part in the genesis of penicillin epilepsy. The use of N-cholinergic-blockers and their combinations with M-cholinomimetics as anticonvulsants seems expedient.

Animals↗
PubMed1984

[Effect of the kallikrein-kinin system on gastric mucosa].

I. m.administration of andecalin increased vascular permeability, induced microhemorrhages in the gastric mucosa and intensified secretion of mucopolysaccharides in patients. Bradykinin inhibited secretion of hydrochloric acid in the frog gastric mucosa. Activity of the kallikrein -kinin system was found to be increased in the blood flowing from the stomach as compared with the system activity in peripheral venous blood in dogs. The kallikrein -kinin system seems to participate in regulation of basic gastric functions, particularly in inhibiting the gastric secretion and in regulation of the mucosa defense barrier.

Adult↗
PubMed1983

[Effect of N- and M- cholinoblockaders on experimental epileptogenesis].

It has been shown in chronic experiments on rabbits with epileptogenic foci provoked by microinjections of penicillin into the dorsal hippocamp that the N-cholinoblockers gangleron (3 mg/k, intravenously) and etherophen (5-10mg/kg, intravenously) possess marked anticonvulsant activity. Diphenin (50 mg/kg, intraperitoneally) was less potent. The M-cholinoblocker methamizil (1 mg/kg, intravenously), on the contrary, potentiated the epileptiform seizures. Emphasis is laid on the necessity of the goal-oriented synthesis and search for agents that would exhibit a "purely" central N-cholinoblocking action with a purpose of applying such agents as antiepileptic drugs. It is not recommended using the M-cholinoblockers for such purposes.

Animals↗
PubMed1983

[Relations between the "dispatch station" and the "destination station" in the formation of pathological reactions].

Experiments on rabbits with electrodes chronically implanted into the cortex and deep brain structures were made to examine the changes that occur during epileptiform reactions induced by electric stimulation of the motor cortex. Formation of different epileptiform reactions, seizures and hyperkineses was dependent on the current intensity and regimen. It is suggested that the development of stable chronic changes on the electrogram and in the animals' behavior in the course of a direct action on the "dispatch" and "destination" stations may be a consequence of the functioning of the determinant "dispatch" station and formation of the pathological system.

Animals↗
PubMed1980

[Role of calcium ions in the evolution of the anticonvulsant effect of taurine].

The decreased microsomal Ca++Mg++ATPase activity and lowered level of Ca++ binding by the brain cortex microsomes in seizure prone rats as compared with normal animals have been revealed. Taurine increases these parameters in experiments in vitro. Injection of taurine into the penicillin-provoked epileptogenic focus prevents the seizure reaction in rabbits. This effect is not observed after injection of taurine together with EGTA. The data obtained demonstrate the important role of calcium ions in the anticonvulsant action of taurine.

Animals↗
PubMed1980

[Ultrastructural characteristics of the dorsal hippocampus in rabbits with epileptiform seizures].

An increase in the medium size of mitochondria in synapses, postsynaptic dendrites and neurons of the dorsal hippocampus was recorded after single and 3fold intracortical injection of penicillin (1000 IE) to rabbits. An increase in the size of vacuoles was found in astrocytes, synapses and postsynaptic dendrites. Mitochondrial hypertrophy indicates the energy output intensification in the form of ATP, while the increased size of vacuoles points to a greater permeability. The changes disclosed evidence an activation of synapses, postsynaptic dendrites and neurons.

Animals↗