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Biomedical subjects

E I Tkachenko

Publications and source records attributed to E I Tkachenko.

54 records · Page 3Linked to original sources

[Effect of micropolarization of focal and extrafocal brain structures on experimental epilepsy].

The influence of micropolarization (MCP, 0.05-0.75 muA) was studied in chronic experiments on rabbits with epileptogenic foci provoked by penicillin (doses of 500 and 1000 U) injection into the motor cortex. A single MCP of extrafocal structure (the corpus calossum, nucleus caudatus) and the site of the focus inhibited the development of seizure reactions. Numerous MCP of the focus facilitated the seizure reactions. These effects may be explained not only by the specific role of the structures studied in the processes of the formation and propagation of the excitation, their initial functional state, but also by the dependence of the activity of these structures on the MCP regimen.

Animals↗

[The effect of micropolarization of the brain on experimental hyperkinesia in dogs].

In chronic experiments on dogs polarization of some cerebral structures could exert an inhibiting, stimulating, or merely a modulating effect on the initial level of involuntary motor activity by changing the trace processes underlying formation of hyperkineses. The simultaneous polarization of the caudate nucleus and motor cortex with DC of 0.5-6.0 mcA was found to reduce or even abolish the involuntary motor reactions, the degree of the effectiveness depending on the degree of their stability.

Animals↗

[Gas analyzer "HelicoSense" as a new device for diagnosis of the Helicobacter infection].

According to recommendations of the European Health Committee, noninvasive methods should be preferred for diagnosis of Helicobacter pylori (HP) infection in children. Equipment and reagents for respiration diagnostic tests available from foreign manufacturers have rather high cost, which hinders their use in domestic medical institutions. A new noninvasive electrochemical technique for HP detection is based on the use of HelicoSense gas analyzer. 150 patients (100 children 6-17 years old and 50 adults 18-78 years old) participated in mulicenter testing of the developed technique. Chronic gastritis was previously diagnosed by endoscopic and morphological examination in all patients. HP status was studied using bacteriological, serological, and cytological methods, as well as the Helpil test. The obtained results were compared to the results of examination with HelicoSense gas analyzer. Our study showed that HelicoSense gas analyzer provides easy use, patient's safety, and possibility of rapid testing. Its application does not require specially trained medical personnel. The device provides high specificity (86.7%) and high sensitivity (93.7%).

Adolescent↗