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Biomedical subjects

E J Perea

Publications and source records attributed to E J Perea.

153 records · Page 9Linked to original sources
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The effect of minocycline, doxycycline and oxytetracycline on experimental mouse toxoplasmosis.

This is a comparative study of the effect of oral and parenteral administration of oxytetracycline, doxycycline and minocycline on experimental acute toxoplasmosis in mice. Two different inocula were used. All the antibiotics were ineffective orally. Doxycycline and minocycline were effective intraperitoneally, curing 90% of the mice who received the smaller inoculum. However, cerebral cysts of T. gondii were more common in the survivors treated with doxycycline.

Administration, Oral↗
PubMedDate not supplied

Clinical experience with cefotaxime (HR-756) in surgical patients.

Twenty adult surgical patients aged between 15 and 83 years (mean:45), 10 of whom had wound infections (one complicated with septicaemia), 2 with septicaemia, 1 with gynecological infection complicated with endocarditis, 5 with urinary tract infections and 2 with lower respiratory tract infections, were treated with parentally-administered cefotaxime. Aetiology was Proteus 7, E. coli 4, Pseudomonas 3, Enterobacter 2, Klebsiella 2 and 2 Serratia. Susceptibility testing was determined by the agar dilution method, with MIC values ranging from 0.01 to 5 microgram/ml, with two urinary isolates of Pseudomonas with MIC of 20 microgram/ml. Clinical responses were excellent in 13 (65 per cent) cases, moderate in 2 (10 per cent) and 3 (15 per cent) failed to respond to therapy. Clinical assessment was not possible in three patients. Bacteriological responses were excellent in 14 (70 per cent) cases, poor in 4 (20 per cent) and in two there was no follow-up. Systemic tolerance was good in all patients except one.

Adolescent↗
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Comparison between plasmids of Salmonella and other enterobacteria isolated from the same patients.

The ecology of R plasmids was studied in the intestinal flora of 19 patients with salmonellosis without antibiotic treatment. The plasmids found in the Salmonella strains and the accompanying non-pathogenic Enterobacteriaceae were characterized in each patient. We determined the transferability by conjugation, the fi character and the incompatibility group and did enzyme restriction analysis of these plasmids. The results obtained showed that S. typhimurium is the species of this genus with the highest incidence of R plasmids, and Escherichia coli among the non-pathogenic Enterobacteriaceae. The plasmids found in Salmonella are different from the plasmids found in the other Enterobacteriaceae in fi character (50% fi+ in Salmonella and 5% in the other Enterobacteriaceae) and incompatibility group (33% belong to the FII group in Salmonella plasmids and none on the other Enterobacteriaceae), thereby expressing a different origin.

Anti-Bacterial Agents↗