Migration of macrophages carrying antigen into the thymus.
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Biomedical subjects
Publications and source records attributed to E Kölsch.
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The murine T cell clone E11, isolated from a primary H-2k-histocompatible, one-way mixed lymphocyte culture of B10.BR anti-C3H/Tif spleen cells, has been used to analyse multidirectional interactions in Mls-disparate responses. Several events can be observed. There is proliferation of T cells upon stimulation by macrophages or B cells of Mls-disparate stimulator cells. In addition, one finds induction of differentiation of B cells of stimulator strains. E11 T cells inhibit spreading and differentiation of macrophages of stimulator strains and also prevent the production of a T cell growth-supporting mediator by Mls-disparate spleen cells. All these phenomena can be explained by Mlsa,d,e-specific induction of gamma-interferon (gamma-IFN) production in the responder B10.BR (Mlsb) E11 T cells. It is suggested that gamma-IFN, as a regulator of feedback mechanisms, plays an essential role in Mls-disparate cell interactions.