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E Knight

Publications and source records attributed to E Knight.

95 records · Page 6Linked to original sources
PubMedDate not supplied

X-ray studies on phospholipid bilayers. II. Polymorphic forms of dipalmitoyl phosphatidylethanolamine.

Oriented films and powder samples of the phospholipid L-alpha-dipalmitoyl phosphatidylethanolamine (DPPE) were studied by X-ray fiber diffraction techniques. The specimens were photographed under a complete range of hydration at room temperature. Two polymorphic forms were found. One of them was present in oriented films. It showed a close packing of DPPE molecules lying parallel to the normal to the bilayer plane. The other form, observed in the powder samples, had the molecules tilted by about 25 degrees. Both forms were characterized by their unit cell dimensions, space groups, molecular conformations and packing arrangements.

Humidity↗
PubMedDate not supplied

Comparison of doxorubicin with cycloleucine in the treatment of sarcomas.

In this patient series, doxorubicin and cycloleucine at a dose of 300 mg/kg both show response rates in the treatment of advanced soft tissue sarcomas of about 15%. Lower doses of cycloleucine (200 mg/kg) yielded less toxicity but were less effective against the sarcomas (6% response rate, three of 51 patients). There were no complete responses with cycloleucine and there were three with doxorubicin. Survival times for patients receiving doxorubicin were significantly longer than those of patients receiving cycloleucine at doses of 300 mg/kg (P less than 0.001) or 200 mg/kg (P = 0.02). The estimated survival times were 29 weeks for doxorubicin and 21 (300 mg/kg) and 18 (200 mg/kg) weeks for cycloleucine. Toxic effects due to cycloleucine were excessive, with severe thrombocytopenia and central nervous system depression being the most prominent.

Adult↗