[Development of osteoporosis].
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Biomedical subjects
Publications and source records attributed to E Krokowski.
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In a prospective study 26 patients with primary or steroid-induced osteoporosis were treated for 15 months with a combined fluoride and calcium preparation. X-ray pictures showed no further aggravation or improvement in 70% of the cases. Bone mineral measurements of the axial skeleton showed no further bone loss in 38% and an increase in bone mineral mass in 54%. Improvement of subjective symptoms was observed in 92%. Recalcification began as expected after nine to twelve months of treatment.
The possibilities of radiotherapy in attending malignant diseases are critically examined. A summary of technical possibilities of radiotherapy ist given. The advantages of high energy radiotherapy are discussed. Preparation and performance of radiotherapy are demonstrated. A critical examination of chemotherapy ist followed by invitation to elaborate a new method of validity.
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Every form of osteoporosis--except the physiological involution osteoporosis--requires treatment. Osteoporosis is no disease by itself but a result or a concomitant phenomenon of various diseases. Therefore the primary disease has to be treated also. Only for the so-called idiopathic osteoporosis hitherto no cause is known. Today sodium fluoride is the only substance with an influence upon the bone which may induce re-ossification and re-stabilization. In the described series of investigations this compound, with which treatment by gradual dosage is possible, has proved its effectiveness. Osteoporosis is more than bone porosity, therefore additionally afflicted organic or functional system like the muscular apparatus, bone marrow, or the intraosseous blood supply, must be treated too. Psychological guidance of the patient is necessary as he must be motivated for activity.
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Cancer screening techniques are of great value in improving the results of treatment of various tumours. Unfortunately screening and early diagnosis of cancers does not improve the prognosis in every case. Early diagnosis may lead to an apparent success without affecting the final outcome of treatment. Early diagnosis may even be harmful to the patient if the diagnostic and therapeutic methods lead to dissemination of the tumour, as has been shown by a number of authors. Consequently cancer screening and early diagnosis should be confined to those selected tumours which are not affected adversely by diagnostic methods.
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Two measures are urgently needed to improve curative therapy results in cancer treatment. 1. Improvements in the early recognition of specific types of tumor and in appropriate modes of preventitive treatment.--2. The introduction of a metastasis prophylaxis before each diagnostic and therapeutic operation for cancer; several possibilities are proposed. The stagnation of cancer therapy results can only be overcome by an alteration in the current concept of treatment, which in cases of early cancer is as yet directed exclusively at the primary tumor.
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The authors analyze the differences of the figures of success communicated in literature for the curative treatment of the mastocarcinoma. They find that neither the therapy method nor the extension of the operated body region are decisive for these figures. The individual success depends on the stage, and the group result is only influenced by the composition of the patients; These observations explain also why the figures of success of the curative therapy of the mastocarcinoma which were based on the stages of the disease have been at a standstill since 25 years. A decisive improvement, however, can be anticipated by virtue of an intensified prevention of mastocarcinoma and a changement of the therapy conception including a prophylaxis against metastases.