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Biomedical subjects

E Lupa

Publications and source records attributed to E Lupa.

At least 19 recordsLinked to original sources
PubMed1992

Prevalence of markers of hepatotropic viruses among drug addicts in Warsaw, Poland.

We studied 100 unselected parenteral drug abusers for infection with hepatitis C, B, A and D virus (HCV, HBV, HAV and HDV). Seventy-six percent had serological evidence of HCV infection. 12% were positive for HBsAg and at least one marker of HBV infection was present in 69%. These results were significantly higher than in a matched control population. Compared to controls, the prevalence of anti-HAV (65%) was not significantly increased in drug addicts. Of the anti-HCV-positive drug addicts, 80.3% had at least one marker of HBV infection compared to 33.3% of anti-HCV-negative cases (p less than 0.001). No such correlation was found between the prevalence of HCV or HBV infection markers and the presence of anti-HAV. Antibodies against HDV were detected in 16 (16%) of the samples from drug addicts. No significant association was found between antibodies to HCV and gender, age and duration of drug abuse. The risk of HBV infection increased significantly with years of drug abuse but was not associated with age and sex. The presence of anti-HAV was related to age only. Sixteen (16%) of the subjects were definitely positive for anti-HIV-1, but at the time of the study they were asymptomatic. No significant association was found between the presence of anti-HIV and the prevalence of serological markers of HBV, HCV, HAV and HDV infection.

Adolescent↗
PubMed1992

Prevalence of markers of hepatitis viruses in out-patient alcoholics.

The prevalence of HCV, HBV and HAV markers was investigated in unselected patients attending an outpatient alcoholic clinic. Anti-HCV were detected in 35 (24%) of 144 patients studied, and at least one marker of HBV infection was present in 72 (50%). These results are significantly higher than in a matched control population. The presence of anti-HCV was related to previous blood transfusions and familial history of alcoholism. We conclude that alcoholics should be considered a high risk group for both HCV and HBV infection.

Adult↗
PubMed1992

[Appearance of antibodies against hepatitis type A virus (HAV) in alcoholics].

In 144 alcoholics--patients of alcoholic outpatient clinic anti-HAV antibodies were studied using the commercially available ELISA test. Anti-HCV antibodies were found in 86% of the alcoholics, and this prevalence was not higher than in the control group. No differences were found in the titre of antibodies against cytomegaly and herpes virus between the subjects with and without anti-HAV antibodies which suggests the specificity f the determined anti-HAV antibodies.

Adult↗
PubMed1992

[Chronic active hepatitis in alcohol abusers].

12 cases of chronic active hepatitis in chronic alcohol abusers are described. All patients were HBsAg negative and 7 were anti-HCV positive. Four out of 5 anti-HCV patients quickly progressed to liver decompensation. It seems that chronic hepatitis seen in chronic alcohol abusers can be divided into two groups: one due to HCV infection and the other due to sensitivity to alcohol, respectively.

Alcoholism↗
PubMed1992

[Occurrence of antibodies against hepatitis C virus (HCV) among alcoholics].

144 consecutive alcoholics attending an outpatient clinic were tested for the prevalence of anti-HCV with commercially available ELISA test (Abbott HCV EIA). Positive sera were further tested with neutralization assay (Abbott HCV Neutralization Assay). Anti-HCV were found in 35 (24%). There was no difference in the prevalence or mean titre of anti-CMV and anti-HSV between patients with and without anti-HCV what points to the specificity of tested antibodies.

Adult↗
PubMed1992

[Occurrence of antibodies against hepatitis C virus (HCV) among drug addicts].

The prevalence of anti-HCV and serological markers of HBV infection was tested in 100 unselected intravenous drug addicts admitted to a detoxification ward. Anti-HCV were present in 78% addicts, and at least one markers of HBV infection was present in 69% addicts. No correlation was found between anti-HCV status and age, gender, duration of addiction or anti-HIV presence. Furthermore, there was no difference in mean titres of anti-CMV and anti-HSV between subjects with and without anti-HCV what suggests that the anti-HCV tested were specific.

Adolescent↗
PubMed1992

[Hepatitis A in drug addicts].

In the years 1982-1988 among patients admitted with the diagnosis of acute virus hepatitis to the Department of Infectious Hepatology, Institute of Infectious and Parasitic Diseases in Warsaw were 25 drug addicts. In 15 of them virus hepatitis B and in 10 virus hepatitis A was recognized. Virus hepatitis A had in the group of addicts a milder course than in controls not taking narcotics.

Acute Disease↗
PubMed1992

[N-acetyl-beta-D-glucosaminidase and diurnal excretion of hydroxyproline in chronic viral hepatitis].

In 37 patients with chronic active hepatitis, in 14 with chronic persistent hepatitis and in 11 with normal histological pattern of the liver the serum activity of N-acetyl-beta-glucosaminidase and the 24-hour excretion of hydroxyproline with urine were determined. The 24-hour excretion of hydroxyproline was similar in all groups of patients, while the activity hepatitis and higher than in those of chronic persistent hepatitis (36.9 +/- 12.9 i.u. per 100 ml versus 22.4 +/- 8.2 i.u. per 100 ml, p less than 0.05). In patients with high serum NAGL activity cirrhosis developed significantly more frequently.

Acetylglucosaminidase↗
PubMed1992

[Markers of HBV infection in drug addicts].

Prevalence of markers of HBV infection was tested in two cohorts of drug addicts: in 140 addicts whose sera were drawn in the years 1985-1986 and in 100 addicts whose sera were drawn in the years 1988-1989. HBsAg was found in 10 (7%) patients in the earlier cohort and in 12 (12%) addicts in the latter, while at least one marker of HBV infection was present in 39% and 69%, respectively No correlation was found between the presence of markers of HBV infection and age, gender, or HIV status, however, duration of drug abuse increased the risk of HBV infection. There was no difference in mean titres of anti-CMV and anti-HSV-1 between subjects with and without HBV markers what suggests that the tested markers were specific.

Acquired Immunodeficiency Syndrome↗
PubMed1991

Course and outcome of acute type B hepatitis in heavy alcohol abusers.

The course and outcome of acute type B hepatitis was analyzed in 30 heavy alcohol abusers. The course of the disease was very similar to that found among non-drinkers, the only difference being higher mean GGT activity and a higher frequency of hepatomegaly among alcoholics. All alcohol abusers cleared the infection in the space of 6 months. However, 2 months after admission, they were twice as likely to be HBsAg positive as controls. We conclude that alcohol abuse has little influence on the course and outcome of acute type B hepatitis.

Adult↗
PubMed1991

Hepatitis C virus antibody in Poland.

To assess the epidemiology of hepatitis C virus (HCV) in Poland, anti-HCV was studied in patients with acute and chronic non-A, non-B (NANB) hepatitis, in healthy adults, and in subjects at risk. Anti-HCV prevalence was 2% in 152 blood donors, 78% in 95 parenteral drug addicts, 21% in 112 alcoholics, and 86% in 42 patients with chronic NANB hepatitis. Among 34 prospectively followed patients with acute NANB hepatitis 17 (50%) developed anti-HCV. It seems that HCV infection is responsible for the majority of NANB hepatitis in Poland and is common in parenteral drug abusers and alcoholics.

Hepacivirus↗
PubMed1991

[Cytomegalovirus hepatitis].

Among 530 consecutive patients hospitalized for acute hepatitis cytomegalovirus infection was diagnosed in 5 (0.9%). In 2 cases the infection was due to blood transfusion. The course of the disease was Got essentially different from hepatitis A, B, or non-A, non-B, however, clinical and biochemical manifestations of cholestasis were common. All biochemical abnormalities returned to normal within few weeks. In conclusion, it seems that cytomegalovirus is a rare cause of clinically overt hepatitis and its course is often cholestatic.

Acute Disease↗
PubMed1991

[Antibodies against Cytomegalovirus and Herpes simplex virus in alcoholics and drug addicts].

Anti-CMV and anti-HSV type 1 of the IgG class were tested in 123 consecutive outpatient alcoholics and 95 consecutive drug addicts admitted to a detoxification ward. The prevalence of both viral markers in these groups was not different from the prevalence found among controls, however, antibody titres were significantly higher. Only weak correlation was found between titres of anti-CMV and anti-HSV in tested subjects. The reasons responsible for high titres of anti-CMV and anti-HSV remain to be determined.

Alcoholism↗
PubMed1991

[Liver damage in alcoholics].

The epidemiology of alcohol abuse and liver disease among alcoholics, with special emphasis on Poland, was reviewed and liver morphological changes attributable to the action of alcohol discussed. Furthermore, possible mechanisms leading to steatosis, alcoholic hepatitis and cirrhosis were discussed in detail followed by brief review of clinical and biochemical abnormalities accompanying alcoholic liver disease and therapy of this disorder.

Alcohol Drinking↗
PubMed1991

[Delta virus infection among drug addicts].

Altogether 240 unselected intravenous drug addicts were tested for the presence of infection with delta virus (HDV). Anti-delta were found in 16 (16%) out of 100 drug addicts tested in the years 1988-1989 and in only one drug addict (0.7%) out of 140 tested in the years 1985-1986. It seems that delta virus has been introduced to Warsaw drug community in the mid-eighties and has spread enormously since that time.

Hepatitis Antibodies↗
PubMed1991

Acute non-A, non-B hepatitis in a hospital population in Warsaw, Poland: clinical and epidemiological aspects.

In the years 1986-1988, 530 consecutive cases of acute viral hepatitis were admitted to an infectious disease hospital in Warsaw. Hepatitis A was diagnosed in 34 cases (6.4%), hepatitis B in 436 (82.3%), CMV infection in five (0.9%), and 55 cases (10.4%) were classified as hepatitis non-A, non-B. In 47 cases (85%) of non-A, non-B hepatitis, there was evidence of parenteral transmission, whereas in eight (15%), the source of infection was unknown. Chronic liver disease developed in 50% of patients with parenteral exposure, but there were no cases with known exposure. Seroconversion to anti-HCV was observed only in patients with parenteral exposure, and 60% of followed up cases developed antibodies within 6 months.

Acute Disease↗
PubMed1991

[Non-A, non-B hepatitis--epidemiologic and clinical aspects].

In the years 1986-90 530 consecutive patients with acute hepatitis were hospitalized in the Department of Hepatology of the Institute of Infectious and Parasitic Diseases in Warsaw. Hepatitis A was diagnosed in 34 cases (6.4%), hepatitis B in 436 (82.3%), CMV infection in 5 (0.9%) and 55 cases (10.4%) were classified as hepatitis non-A, non-B. In 47 cases (85%) of non-A, non-B hepatitis in 8 (15%) the source of infection was unclear. In 50% of patients with parenteral exposure transaminases remained elevated for longer than 6 months, while all patients with no known exposure recovered.

Adult↗