PubMed Health⌕ Search

Biomedical subjects

E Lupa

Publications and source records attributed to E Lupa.

At least 37 records · Page 2Linked to original sources
PubMed1990

Liver disease among Polish alcoholics. Contribution of chronic active hepatitis to liver pathology.

A group of 70 chronic alcoholics--65 men and 6 women--has been studied. HBsAg was found in 11 (16%), and at least one marker of HBV infection was present in sera from 31 (44%) persons, these results being significantly higher than in a matched control population. The commonest single histological patterns were: steatosis (18 cases), and alcoholic hepatitis (18 cases), followed by normal liver (14 cases) and chronic active hepatitis (12 cases). Cirrhosis was diagnosed in only 4 cases. Five cases of chronic active hepatitis could be attributed to infection with HBV or HDV; in the remaining 7 cases the etiology was unclear. Infection with HBV seems to play an important role as the cause of liver disease among alcoholics in Poland, and chronic active hepatitis of various etiology may be an important form of liver pathology among them.

Adult↗
PubMed1990

Cytomegalovirus infection presenting as hepatitis.

Among 530 consecutive patients hospitalized for acute hepatitis in the years 1986-1988 cytomegalovirus infection was diagnosed in 5 (0.9%). All 5 patients had symptomatic hepatitis with jaundice, 3 had pruritus. Hematological changes were relatively mild and liver function tests were not essentially different from those found in patients with hepatitis A, B, or non-A, non-B. All biochemical abnormalities returned to normal within 3-5 weeks.

Adolescent↗
PubMed1989

[Severe alcoholic hepatitis].

A case of severe alcoholic hepatitis was observed in a man aged 30 years. Attention is called to possible diagnostic and therapeutic difficulties. Despite abstinence lasting 9 months the results of biochemical tests failed to return to normal values.

Adult↗
PubMed1989

[Liver damage in alcoholics].

The authors made a liver biopsy in a group of 42 persons chronically abusing alcohol. In the majority of patients the authors found various forms of hepatopathology: fatty degeneration--8 cases (19%), alcoholic hepatitis--10 cases (24%), chronic active hepatitis--11 cases (26%), and hepatocirrhosis--2 cases (5%). The authors found no correlation between the kind and degree of liver damage and the amount of alcohol drunk, which suggests the role of individual hypersensitivity in the development of hepatopathology in alcoholics. In some of the alcoholics liver damage was connected with infection by HBV--5 cases (12%) and the participation of alcohol in the pathogenesis of chronic active hepatitis seems likely but it still remains not verified. The results of the investigation carried out point to the need of histological examination of the liver in alcoholics.

Adult↗
PubMed1988

Prevalence of hepatitis B virus markers among Polish urban alcoholics.

124 consecutive patients (mean age: 41.1 years; range: 20-63 years) attending an outpatient alcoholic clinic were tested for the presence of markers of HBV infection. HBsAg was found in 26 (21%), anti-HBs and/or anti-HBc in the absence of HBsAg in 35 (28%). Altogether, at least one marker was present in 61 (49%), these results being significantly higher than in a matched control population. In 70 cases HBV status was compared with epidemiological data. No relationship was found with past blood transfusions, hospitalization or jaundice. HBV infection was, however, more common when parents of the subjects were alcoholics, which points to a possible role of family spreading. Furthermore, chronic infection with HBV was related to high alcohol intake.

Adult↗
PubMed1988

Prevalence of hepatitis B virus markers among Polish alcoholics.

102 consecutive alcoholics attending an outpatient alcoholic clinic were tested for hepatitis B virus (HBV) markers in serum. HBsAg was found in 21, anti-HBs in 22 and anti-HBc in 42; at least 1 marker was present in 49. These results were significantly higher than in a matched control population. Out of 21 HBsAg positive cases 7 had markers of ongoing viral replication as judged by the presence of HBeAg and HBV DNA.

Adult↗
PubMedDate not supplied

Introduction of hepatitis delta virus into Polish drug community.

The prevalence of hepatitis delta virus (HDV) infection was studied in 140 unselected intravenous drug addicts whose sera were drawn between 1985 and 1986 and in 100 addicts from whom sera were obtained between 1988 and 1989. It was observed that 1.8% of those positive for hepatitis B virus (HBV) markers from the earlier period and 23.2% of those from the later period had detectable anti-delta antibodies. Among drug addicts referred with acute or chronic HBV infection, the first evidence of HDV infection was found in 1986. We conclude that HDV infection was introduced into the Warsaw drug community in the mid 1980s.

Carrier State↗
PubMedDate not supplied

[Hepatitis B among drug addicts].

In the years 1980-1988 twenty five drug addicts were identified among 1841 patients hospitalized for acute hepatitis in the Dep. of Hepatology at the Institute of Infectious and Parasitic Diseases in Warsaw. 15 drug addicts had hepatitis B and 10 had hepatitis A. It was found, that the course of acute type B hepatitis was milder in drug addicts, than among control group consisting of non-addicts.

Acute Disease↗
PubMedDate not supplied

[Procollagen type III peptides in chronic viral hepatitis].

Blood serum concentration of procollagen type III peptides was assayed in 37 patients with chronic active hepatitis, 14 patients with persisting chronic hepatitis, and 11 normal subjects. Mean concentration of these peptides was significantly higher in patients with chronic active hepatitis than in those with persisting chronic hepatitis (25.6 +/- 11.5 ng/mL vs. 14.0 +/- 4.5 ng/mL; p < 0.001), and in individuals without lesions to the liver (25.6 +/- 11.5 ng/mL vs. 12.5 +/- 2.9 ng/mL; p < 0.001). Blood serum concentration of procollagen type III peptides may be helpful in the differential diagnosis of hepatitis.

Adult↗
PubMedDate not supplied

[Value of routine biochemical investigations for detection of liver injury in alcoholics during abstinence].

In 42 alcoholics biopsy of the liver was done during the period of abstinence and the following biochemical investigations were carried out at the same time: AspAT, A1AT, GGTP, alkaline phosphatase activity, total serum protein level, protein electrophoretic fractions, levels of urea and fibrinogen, prothrombin index and white blood cell count. In these investigations determination of transaminase activity was found to be most sensitive in the detection of hepatocellular damage. In some patients no abnormalities were found in biochemical investigations despite presence of high-grade changes in the liver in histological examination.

Adult↗
PubMedDate not supplied

[Chronic active hepatitis in alcoholics].

In 42 chronic alcohol abusers liver biopsy was performed and chronic active hepatitis was diagnosed in 11 cases. In 4 cases etiology could be attributed to chronic HBV infection--they were positive for HBsAg in serum, three were positive for HBeAg and one case had anti-delta antibodies. In 7 cases etiology was obscure, at least in some of them alcohol could have been the underlying factor. Liver disease in these particular cases was clinically more severe than chronic active hepatitis due to infection with HBV and non-A, non-B viruses in non-drinkers. Two cases progressed into liver decompensation despite 1 and 2 years of abstinence, respectively. Chronic active hepatitis in alcoholics constitutes a frequent pathology, its etiology is variable, in some cases obscure.

Adult↗
PubMedDate not supplied

[Markers of hepatitis A infection in drug addicts].

Prevalence of HAV infection markers was studied in 100 drug addicts whose sera were collected between 1988 and 1989. Anti-HAV antibodies were found in 65 (65%) of the tested drug addicts and in 55% of the individuals serving as the control group. No correlation between the presence of HAV infection markers, and sex, duration of drug abuse or HIV status was seen. However, drug addicts with anti-HAV antibodies were older than those without these antibodies. There was no difference in a mean titre of anti-CMV and anti-HSV type 1 antibodies between the individuals with and without HAV infection markers. It suggests that the tested markers are specific for HAV infection.

Adult↗