Biomedical subjects

E M Huffman

Publications and source records attributed to E M Huffman.

20 records · Page 2Linked to original sources

PubMed1981

Serum chloramphenicol concentrations in preruminant calves: a comparison of two formulations dosed orally.

Serum concentrations of chloramphenicol were determined after oral doses (55 mg/kg body weight) were administered to 7-9 day old Holstein-Friesian calves. Chloramphenicol in an oral solution produced greater serum concentrations than did an equivalent dose of chloramphenicol in capsules (P less than 0.005). A second dose of each formulation administered 12 h after the first dose elevated serum chloramphenicol concentrations significantly (P less than 0.001). The average serum chloramphenicol concentration exceeded 5 micrograms/ml of serum 1 h after administration of the solution compared with 4 h for the capsules. Average serum chloramphenicol concentration was greater than 5 micrograms/ml for at least 12 h after the dose was administered for both formulations. Of the eight calves receiving repeat doses of chloramphenicol, seven (87.5%) developed diarrhea in 76 +/- 8.6 h. Six of the eight calves (75%) died during or shortly after the period of chloramphenicol administration.

Administration, Oral↗

PubMed1980

Mastitis and udder abnormalities as related to neonatal lamb mortality in shed-lambed range ewes.

Bacterial isolations were attempted from milk samples taken from 242 range ewes in a southwestern Idaho shed lambing enterprise. Eighty-five percent of the ewe milk samples had no pathogenic bacterial growth at lambing and 3 weeks later. The few organisms that were isolated did not appear to affect udder condition of the ewe or contribute to lamb mortality. Shed conditions did not affect the frequency of isolation of potentially pathogenic bacteria. The prevalence of udder abnormalities, however, did appear to have a positive association with ewes that lost theim lambs. The most frequent abnormality was a diffuse homogeneous induration of the udder. This hardening was apparently unrelated to bacterial isolation or the age of the ewes. Mastitis, either subclinical or clinical, did not appear to be a serious problem in this particular flock. Mastitis was not related to lamb mortality.

Animals↗