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Biomedical subjects

E Miller

Publications and source records attributed to E Miller.

At least 37 records · Page 2Linked to original sources
PubMed1978

Maturation of the visual evoked response in newborn miniature pigs.

As a prelude to neurobehavioral toxicologic studies in neonatal minipigs, normal maturational changes in the visual evoked response (VER) were determined in 6 Hormel-bred minipigs. The VER were highly variable for the 1st several days of life, but were reasonably stable by the 2nd weeks. All adult waveform components were present at birth, and maturational changes primarily affected waveform latency and consistency. Only one waveform (Pi) was sufficiently distinct and consistent for statistical evaluation. At birth the latency to Pi was about 102 ms. The latency of Pi rapidly decreased to about 56 ms during the next 25 days, and subsequent changes were minimal. Comparison with other species indicates many cross-species relationships of specific VER components, with the minipig VER having many maturational and topographic similarities to the human VER.

Animals↗
PubMed1978

Preliminary report of the distribution of [14C]penicillic acid in rats: autoradiographic technique.

The distribution of [14C]penicillic acid in rats was determined by autoradiographic technique. Adult male rats were given [14C]penicillic acid orally and IV. According to autoradiographic analyses 24 hours later, high levels of radioactivity were in liver, heart, kidneys, lungs, and caudal part of the intestine. The significance of bile as an excretory route for penicillic acid was confirmed by the results from IV administration of the compound.

Administration, Oral↗
PubMed1977

Polyurethane foam (Bentley) micropore blood transfusion filter: filtration characteristics.

Stored human blood of varying age was passed through polyurethane foam (Bentley) micropore blood transfusion filters. Passage through these filters resulted in decreased screen filtration pressure (SFP) of the blood and increased filter weights. Numerous microaggregates were removed and SFP returned to normal after filtration. Occlusion of the filter occurred after passage of only 2 units of whole blood. On the basis of this research, we conclude that polyurethane foam (Bentley) micropore blood transfusion filters are effective in removal of microaggregates from stored human blood. Because the filtering capacity is not great, it is recommended that when these filters are used during transfusion a new filter be used for each unit of blood administered.

Blood Preservation↗
PubMed1977

Carcinogenicity of fibrous glass: pleural response in the rat in relation to fiber dimension.

Seventeen fibrous glasses of diverse type or dimensional distribution induced different incidences of malignant mesenchymal neoplasms when implanted in the pleurae of female Osborne-Mendel rats for periods of more than 1 year. Neoplastic response correlated well with the dimensional distribution of fibers. Fibers less than or equal to 1.5 mu in diameter and greater than 8 mu in length yielded the highest probability of pleural sarcomas, and probability trends suggested that pleural sarcoma incidence increased with increasing lengths of fibers with diameters of less than 1.5 mu, Morphologic observations indicated that fibers less than or equal to 8 mu in length were inactivated by phagocytosis. In fibers greater than 8 mu in length, the correlation of carcinogenicity witth increasing length was difficult to explain. Since neoplastic response to a variety of types of durable fibers, particularly asbestos fibers, was similar, our experiments reinforce the idea that the carcinogenicity of fibers depends on dimension and durability rather than physicochemical properties and emphasize that all respirable fibers be viewed with caution.

Animals↗
PubMed1977

The management of dementia: a review of some possibilities.

Evidence relating to the effects of therapeutic intervention on the behaviour of elderly demented patients is reviewed. Contrary to common prejudice there is strong evidence that improvements in functioning can be achieved by social and behavioural manipulations although maintaining such gains may be more difficult. There are some indications as to what type of intervention is likely to be most effective and some specific techniques that might be of use are discussed.

Attitude of Health Personnel↗
PubMed1976

Filtration characteristics of polyester mesh (Pall) micropore blood transfusion filter.

Stored human blood of varying age was passed through polyester mesh (Pall) micropore blood transfusion (pore size, 40 mu). Passage through the filter resulted in decreased screen filtration pressure (SFP) of the blood and increased filter weight. Mumerous microaggregates were removed, but SFP did not return to normal after filtration. On the basis of this research, we conclude that polyester mesh micropore blood transfusion filters are not as effective as Dacron wool (Swank) transfusion filters in removal of micro-aggregates from stored human blood. If a polyester mesh filter must be used, it is recommended that once occlusion of the filter has occurred, the filter should then be discarded and another inserted.

Blood Preservation↗
PubMed1976

Gunshot wounds of the abdomen. A review of 277 cases.

During a five-year period from July 1968 throuhgh June 1973, 277 abdominal gunshot wounds (GSWs) occurred, the overall fatality of which was 10%. Abdominal exploration was done in all patients. No intra-abdominal injury was found in 40 patients (14%) and no death occurred in this group. There were 28 fatalities (12%) in 237 patients (86%) who had intra-abdominal injuries. Morbidity and mortality were related not only to the number of organs injured, but also to specific organs injured. The leading cause of early death was hypovolemia due to major vessel injuries. Septicemia was the most common cause of death if the patient survived the first 24 hours of hospitalization. Penetrating abdominal stab wounds and gunshot wounds must be considered separately, and mandatory routine abdominal exploration for all penetrating gunshot wounds is advised. In stab wounds to the abdomen, conservative management may be preferable.

Abdominal Injuries↗
PubMed1976

A comparison of flexible and nonflexible plastic cannulae for performing first trimester abortion.

The safety and effectiveness of flexible and nonflexible plastic cannulae used in vacuum aspiration abortion for patients at 6 to 12 weeks' gestation were evaluated in a study of 1100 physically healthy women in Ljublijana, Yugoslavia. To minimize study biases, each type of cannulae was randomly assigned to 550 patients. To minimize evaluator bias, a second physician who was kept unaware of which cannula was used for particular patient was responsible for evaluating patients after the procedures. Both groups of patients were similar with respect to age, parity, marital status, formal education and gestational age. Higher rates of retained tissue and cannula obstruction were obtained with the flexible cannula. The two types of cannulae were not significantly different with respect to other criteria of evaluation.

Abortion, Induced↗
PubMed1976

Microaggregate formation in stored human packed cells: comparison with formation in stored whole blood and a method for their removal.

Experiments were performed to compare the formation of microaggregates in stored human whole blood (WB) with that in stored packed cells (PC) and also to compare the effectiveness of standard blood transfusion filters with dacron wool (Swank) micropore transfusion filters in removing such microaggregates. After 5, 10, 15 and 20 days of storage SFP and debris weights of PC's were considerably greater than those of matched WB samples. Passage of either WB or PC's through standard blood transfusion filters resulted in small decreases in SFP and debris weights. Passage of either WB or PC's through dacron wool (Swank) transfusion filters led to striking and highly significant decreases in both SFP and debris weights. When stored PC's were diluted to the same hematocrits as their corresponding WB samples, SFP remained considerably elevated above those of the WB samples. On the basis of this research, it is concluded that centrifugation of blood during component separation leads to a significant increase in microaggregate formation over and above that which progressively occurs during storage and that the risk of pulmonary microembolization during transfusion with stored PC's is greater than that during WB transfusion. For this reason, dacron wool (Swank) filters should always be used when PC's are being transfused.

Blood Preservation↗