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E P Dekonenko

Publications and source records attributed to E P Dekonenko.

46 records · Page 3Linked to original sources
PubMed1982

[Clinical forms of chronic neuroinfections (organization of research, etiology and pathogenesis, therapeutic principles)].

The results of complex examination of 489 patients suffering from chronic neuroinfections (progressing forms of tick-borne encephalitis, disseminated sclerosis, disseminated encephalomyelitis, subacute sclerosing panencephalitis, etc.) are presented. An analysis of the results of virological, immunological, genetic and electrophysiological examinations, as well as the results of kinesotherapy has demonstrated a definite role of hereditary peculiarities of the immune mechanisms and the nervous system in the genesis of those diseases, as well as certain common features of the pathogenetic mechanisms. This enables one to outline some general principles of the therapy of those diseases.

Alzheimer Disease↗
PubMed1981

[Immunotherapy of certain acute and chronic forms of neuroinfections (tick-borne encephalitis, multiple sclerosis, disseminated encephalomyelitis)].

The pathogenetic community of various viral neuroinfections different in their form and course points out that the use of means targeted at correction of the immune system functions is desirable. As a result of using combined immunotherapy methods the authors have obtained positive results in treating 38 patients suffering from some acute and chronic neuroinfections (grave local forms of acute tick-borne encephalitis, progredient forms of the same encephalitis, disseminated sclerosis, disseminated encephalomyelitis). Interrelations between the immunity factors are studied, and their role in the therapeutic effect obtained is discussed. The scheme and the result of the treatment, as well as general principles of dynamic observation and treatment of those patients are presented.

Adult↗
PubMedDate not supplied

[Use of a conjugate of staphylococcal protein A with peroxidase in an immunoenzyme test system for determining antibodies to the herpes simplex virus].

An enzyme-immunoassay system for the detection of specific antibody to herpes simplex virus was developed in which the antigen layered on the solid phase consisted of a crude extract of infected cells, and the detecting agent was a conjugate of protein A with horseradish peroxidase. This assay system was used for serological examination of 22 serum specimens from patients suffering from either meningoencephalitis or recurrent herpes of the skin and mucous membranes of the genitalia, as well as 6 specimens of the cerebrospinal fluid from patients with meningoencephalitis. The enzymeimmunoassay was found to be more sensitive than CFT. The advantages of using protein A/peroxidase conjugate for rapid estimation of the total amount of specific antibodies at any stage of herpes infection are discussed.

Adult↗
PubMedDate not supplied

[Immunoenzyme method in the diagnosis of tick-borne encephalitis].

Data are presented on the use of direct and indirect enzyme-immunoassay (EIA) in the study of tick-borne encephalitis (TBE) virus. EIA has been shown to be considerably more effective than the conventional CFT and HI tests exceeding them in sensitivity by 50-150 times both in studies of the antigenic activity of various preparations and in examinations of human sera. The possibility of testing various antigenic substrates makes EIA a universal method suitable for numerous studies. The high sensitivity of the method is useful for antigenic differentiation of viruses and strains within the TBE complex. The EIA may be used satisfactorily for early diagnosis of TBE and study of seroconversion in vaccines.

Animals↗
PubMedDate not supplied

[Results of a serological examination of amyotrophic lateral sclerosis patients].

Examinations of specimens from 12 patients with amyotrophic lateral sclerosis (ALS) by means of enzyme-labeled immunosorbent assay (ELISA) and solid-phase radioimmunoassay ( SPIRA ) demonstrated antibody to lymphocytic choriomeningitis virus (LCM) in the blood sera of 3 patients and antigens of LCM virus in sera of 2 other patients. LCM virus antigen was also found in organs of a patient who died of ALS. LCM virus was isolated from the serum of one patient positive for LCM antigen by inoculation of newborn white mice. The new isolate (the Kanta -220 strain) examined by electron microscope was shown to have some morphological differences from the museum strain CA-1371 of LCM virus available in the laboratory.

Adult↗