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Biomedical subjects

E Persson

Publications and source records attributed to E Persson.

At least 145 records · Page 8Linked to original sources
PubMed1987

Plasma kinetics of lipoprotein lipase and hepatic lipase activities induced by heparin and a low molecular weight heparin fragment.

Intravenous injections of conventional heparin and a low molecular weight heparin fragment (LMWH, mean molecular weight 4000-6000) were given to six male volunteers at doses of 10, 50 and 100 U (antiFXa)/kg body wt. The plasma kinetics of lipoprotein lipase (LPL) and hepatic lipase (HL) were analysed. The peak values, as well as the accumulated release of LPL activity, were dose dependent and were twice as high after heparin as after LMWH. The plasma half-life of LPL activity followed first order kinetics and was similar for both heparin preparations when given in comparable doses. The peak values and the plasma half-life of HL activity were the same for heparin and LMWH in the clinically relevant doses (50 and 100 U (antiFXa)/kg). Compared with LMWH, the total release of HL was twice as large after the heparin injections, possibly due to mobilization of an additional enzyme pool by the conventional heparin. It is concluded that the use of LMWH as an anticoagulant is associated with a lower plasma lipolytic activity than with standard heparin.

Adult↗
PubMed1986

Actinomyces israelii-associated salpingitis.

Actinomyces israelii was identified in samples from the oviducts of 4/100 women with salpingitis diagnosed by laparoscopy. All four cases healed on 'routine' treatment. Possible pathogenic mechanisms for the development of actinomycosis are discussed.

Actinomyces↗
PubMed1986

The autism-fragile-X syndrome (AFRAX): a population-based study of ten boys.

This study reports on the neuropsychiatric findings in a population-based series of ten infantile autistic boys, aged 2-17 years, who also showed the fragile-X (q27) chromosome marker. Epilepsy, brainstem dysfunction and a range of psychiatric symptoms not inherent in the autism diagnosis were present. Theoretical and practical issues are discussed.

Adolescent↗
PubMed1986

Psychiatric disorders in mildly and severely mentally retarded urban children and adolescents: epidemiological aspects.

A total of 149 children aged 13-17 years were examined. 83 were mildly and 66 severely mentally retarded. These children, especially the severely retarded ones, are representative of all mentally retarded children born in 1966-1970 and living in Göteborg, Sweden. 64% of the severely mentally retarded and 57% of the mildly mentally retarded children were suffering from a handicapping psychiatric condition. Autism-like 'psychotic behaviour' was common in the severely retarded. 0.2% of the total child population aged 13-17 years suffering from the combination of mental retardation and 'psychotic behaviour'. Epilepsy was associated with psychiatric abnormality, but Down's syndrome was generally not so associated.

Adolescent↗
PubMed1985

Lipolytic and anticoagulant activities of a low molecular weight fragment of heparin.

Low molecular weight heparin (LMWH) and standard heparin were given intravenously to six healthy subjects receiving a continuous infusion of Intralipid. After infusion, antifactor Xa, antithrombin II and coagulation activity (Normotest) were the same for both heparins. Activated partial thromboplastin time increased significantly, but the increase was much higher after standard heparin (+473%) than after LMWH (+48%). The increase in lipoprotein lipase activity was less pronounced after LMWH infusion. This resulted in a smaller decrease in Intralipid-triglyceride concentration and a smaller increase in both plasma FFA concentration and Intralipid fractional removal rate compared to standard heparin. This study shows that the plasma lipolytic potential of LMWH is weaker than that of standard heparin when given in doses with equipotent anticoagulation. LMWH may therefore be preferable to standard heparin as an antithrombotic agent in clinical situations where a high plasma lipolytic activity may be disadvantageous.

Adult↗
PubMed1985

Isolation of leukaemia-associated inhibitor (LAI)-producing cells from normal peripheral blood.

LAI, leukaemia-associated inhibitor, has previously been shown to be produced by a subpopulation of null cells in myeloid leukaemia, and has the capacity to suppress the proliferation of normal granulopoietic stem cells, CFU-GM, in vitro. In the present study, low density mononuclear cells from normal peripheral blood were separated into adherent/non-adherent, phagocytic/non-phagocytic, T-lymphocytes/non-T cells, and Fc-receptor positive and negative cells in search for LAI-producing cells in normal blood. Cell fractions enriched for NK-cells were isolated from Percoll gradients and NK-activity and LAI-production were assayed in the different fractions. Anti-Leu-2, anti-Leu-3, and anti-HLA-DR were used to deplete mononuclear cells of cells positive for these monoclonals using a panning technique. It is concluded from these studies that normal LAI-producing cells belong to a non-adherent, non-phagocytic, non-T, non-B, Fc-receptor positive population which does not express NK-activity, and which is Leu-2, Leu-3 and HLA-DR negative. The results imply that LAI may be a novel feedback regulator of the proliferative rate of granulopoietic stem cells and that LAI is produced by a small subpopulation of cells in both blood and bone marrow.

Antibodies, Monoclonal↗
PubMed1985

Study of precipitation reactions to Actinomyces israelii antigens in uterine secretions.

Uterine secretions were obtained from 110 women and analysed by counterimmunoelectrophoresis for the occurrence of precipitation reactions against Actinomyces israelii antigens. Precipitation reactions were found in secretions from seven women and a correlation was found between these reactions and long term use of plastic intrauterine devices. The precipitating components could not be proved to be immunoglobulins; neither could identity be shown with IgG precipitins in reference serum. The nature and the importance of the precipitating components are discussed.

Actinomyces↗
PubMed1985

Effect of zinc and other cations on the release of the eosinophil cationic protein.

The eosinophil cationic protein, ECP, is a unique eosinophil granule constituent, which is released extracellularly after exposure of the eosinophils to a non-phagocytosable surface such as complement-coated Sephadex beads. The ECP is released to some extent even in the absence of Ca2+ and Mg2+, though both these cations augment the release reaction tested alone, and an optimal release is observed only in the presence of 2 mmol/l Ca2+ and 2 mmol/l Mg2+ in the medium. Zn2+ at concentrations from 0.25-4.0 mmol/l inhibited the release of ECP in a dose-dependent fashion, with or without Ca2+ and Mg2+ in the medium. Mn2+ had dual effects, stimulating the ECP release in the absence of Mg2+ and Ca2+, and inhibiting the release in the presence of these cations. Li1+ caused minor inhibition of ECP release, but only in the absence of Ca2+ and Mg2+. The inhibitory effect of Zn2+ was immediate and reversible after washing of the cells, suggesting that the inhibition is due to interaction with the plasma membrane functions.

Blood Proteins↗
PubMed1984

Clinical evaluation of precipitin tests for genital actinomycosis.

A precipitin test system for antibodies against Actinomyces israelii, comprising a combination of counterimmunoelectrophoretic and crossed immunoelectrophoretic gel techniques, was evaluated for its clinical usefulness in diagnosing genital actinomycosis. A total of 263 serum samples from healthy women and women with proven actinomycosis, A. israelii-associated salpingitis, other gynecological infections, or miscellaneous gynecological diseases were analyzed. Six different precipitins could be detected. Five precipitins were defined as specific for actinomycosis, whereas one was found to occur nonspecifically in women with gynecological infections. The specificity of the test system for the detection of cases of genital actinomycosis was 98%, and the sensitivity was 83%. The accuracy was 100% for negative prediction and 45% for positive prediction. Thus, the test was shown to be valuable for a noninvasive diagnosis of genital actinomycosis.

Actinomyces↗
PubMed1984

Genital colonization by Actinomyces israelii and serologic immune response to the bacterium after five years use of the same copper intra-uterine device.

An increased risk of developing genital actinomycosis has been found with long-term use of IUDs. In this study a group of women who had used their IUDs for 60 +/- 6 months was compared with a group having worn their IUDs for 36 +/- 6 months. None of the women examined had symptoms of genital infection. No significant differences could be found in colonization frequency of A. israelii on the IUDs or in humoral antibody response to the bacterium.

Actinomycosis↗
PubMed1984

A longitudinal study of Actinomyces israelii in the female genital tract.

A prospective longitudinal investigation was performed to study variations in the occurrence of Actinomyces israelii with reference to four microorganisms, staphylococci, E. coli, P. acnes and C. albicans, in the female genital tract. Fifteen healthy women were studied during all phases of the menstrual cycle. Sampling was made from the cervix, vagina and perineal area three times a week during two consecutive menstrual periods and during menstruation from napkins and tampons. Altogether 1108 samples were taken on 349 sampling occasions for different cultural procedures. A. israelii was identified in all women, in varying frequencies (range 4 to 74% of sampling occasions). As a mean, A. israelii was recovered in 24% of the perineal samples, 13% of the vaginal and 6% of the cervical samples. The occurrence of A. israelii was related neither to the recovery of reference microorganisms nor to the phase of the menstrual cycle, the amount of bleeding or discharge, the pH of the vaginal specimens, the contraceptive method used, or to the use of different sanitary products. It is our conclusion that A. israelii appears to be a part of the indigenous genital flora of healthy women.

Actinomyces↗
PubMed1983

Actinomyces israelii in the genital tract of women with and without intra-uterine contraceptive devices.

Actinomycosis involving the female genital tract is more common among IUD users than others. The diagnosis is difficult and often delayed. It has been suggested that the finding of Actinomyces-like organisms or A. israelii in cervical smears indicates a risk of developing actinomycosis. A. israelii has not been regarded as a part of the indigenous genital flora. A group of IUD users without symptoms of genital tract infections were compared with a control group without IUDs. No Actinomyces-like organisms were found on cytological examination of cervical smears. Immunofluorescent staining and cultures identified A. israelii in 4% of the IUD users and in 3% of the non-users. Serologic precipitin tests for actinomycosis were negative in all women. None developed actinomycosis on follow-up of positive cases. The study indicates that A. israelii is a commensal of the female genital tract. The identification of A. israelii alone does not indicate that the patient risks developing actinomycosis. Other methods such as a serology test should be useful in defining the clinical significance of the findings.

Actinomyces↗
PubMed1981

Kidney radioprotection by temporary hypoxia. Experiments with degradable microspheres.

Deep hypoxia protects biological tissue against ionizing radiation. By intra-arterial injection of degradable starch microspheres the renal circulation was temporarily blocked in unilaterally nephrectomized rats. The induced hypoxia was utilized for protection of the kidney against single doses of high-voltage X-rays. Renal function and survival date were compared between animals protected by hypoxia and non-protected animals. The survival rate of the former animals exceeded that of the latter by a factor of 1.6. All irradiated animals showed a lower glomerular filtration rate, Hippuran clearance and urine osmolarity than non-irradiated controls. Surviving, protected animals irradiated with 42 Gy and 52 Gy showed a glomerular filtration rate of about 0.5 ml/min and a Hippuran clearance of about 2 ml/min, whereas all non-protected animals irradiated with 42 Gy died.

Animals↗
PubMed1980

Propranolol in chronic schizophrenia: a controlled study in neuroleptic-treated patients.

The effect of propranolol at a dose level of 1,280-1,920 mg per day was studied with a double-blind crossover design in twelve chronic schizophrenics with persistent psychotic symptoms despite maintenance treatment with a depot neuroleptic. By use of a psychiatric rating scale (CPRS), an improvement was seen during the two week period of propranolol compared to placebo treatment in six patients, whereas three patients were unchanged and three deteriorated. The effect on total symptom scores for the whole group was significantly better after propranolol. The data indicate that propranolol in high doses has an antipsychotic effect in some schizophrenic patients when receiving neuroleptics.

Adult↗