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Biomedical subjects

E Persson

Publications and source records attributed to E Persson.

At least 163 records · Page 9Linked to original sources
PubMed1977

Thyrotropin-releasing hormone (TRH) inchronic schizophrenia. A controlled study.

A controlled study on the effect of synthetic Thyrotropin-Releasing Hormone (TRH) versus placebo in 10 drug-free chronic schizophrenics is presented. TRH 600 mug or placebo was administered intravenously on 4 consecutive days in a double-blind cross-over design and the schizophrenic symptoms were scored daily by use of two rating scales (CPRS and NOSIE). Blood samples were taken before and 30 and 45 minutes after the first and the fourth injection and analyzed for TSH. No changes in symptom intensity were found during the TRH or placebo treatment period and no difference was obtained between the two treatments. The dose of TRH used caused a significant increase in the plasma level of TSH which indicated a normal pituitary responsiveness to TRH. The data do not support the notion that TRH has a beneficial effect in chronic schizophrenic patients.

Adult↗
PubMed1975

DC temperature-regulating device for anesthetized experimental animals.

A temperature-regulating device for anesthetized experimental animals is presented. The rectal temperature of the animal is measured with a thermistor and this variable controls via nonlinear amplification the power fed to the heating pad on which the animal is placed. Rectal temperature variations of not more than +/- 0.1 degrees C are reached after 30 min of operation.

Anesthesia↗
PubMedDate not supplied

Carbonic anhydrase activity in different placenta types: a comparative study of pig, horse, cow, mink, rat, and human.

The placenta has multiple functions, being the organ which provides oxygen and nutrients to the developing conceptus. In the placenta, the enzyme carbonic anhydrase (CA) may provide ions for exchange with Na+, K+, and Cl- in transepithelial movement of ions and fluid, as well as facilitating carbon dioxide diffusion. It can also be active in intermediary metabolism, such as gluconeogenesis, urea, and fatty acid synthesis. Placental material from pig, horse, cow, mink, rat, and human was therefore investigated, representing placenta types with variations in shape, internal architecture, and nature of the interhemal barrier. After glutaraldehyde fixation, sections were stained by a histochemical CA-method demonstrating all active isozymes. The most striking feature in common was a positive reaction in the maternal capillaries, when present, as in pig, horse, cow, and mink. In the maternal epithelium, the activation of CA was only observed in the pig, which also exhibited the strongest activity at the maternal interface, which reacted moderately in rat, weakly in horse, and was not visible in cow and human. The trophoblast was positive in pig and rat, whereas it was negative in horse, cow, human, and mink placentae except for few scattered trophoblast cells in pig, horse, and cow, which showed very intense activity. In the fetal capillaries, a positive reactivity was only observed in mink and human. The utilization of CA in placental transfer and metabolism is thus highest in the pig, rat, and mink, compared with horse, cow, and human. It can therefore be concluded that the activation and localization of CA in the placental interhemal barrier varies considerably among species.

Animals↗
PubMedDate not supplied

Immunocytochemical localization of growth factors and intermediate filaments during the establishment of the porcine placenta.

The immunocytochemical localization of insulin-like growth factor I (IGF-I) and platelet-derived growth factor A (PDGF-A) chain ligands, PDGF-chain receptors, and the intermediate filaments cytokeratin, desmin, and vimentin in the tissue reorganization and development during the establishment of the porcine epitheliochorial placenta was studied at light and electron microscopic levels in sections of endometrium and/or placenta of gilts during early pregnancy up to day 40 postmating. The endometrial epithelia (surface and glandular) as well as the trophoblast showed PDGF-A and IGF-I labelling. The only temporal difference was seen regarding IGF-I labelling, this being more uniform in the glands during precontact and early contact stages (days 7-12) compared to later stages. Cytokeratin labelling was conspicuous in all epithelia, including the trophoblast. The endometrial stroma showed strong labelling for the PDGF receptors and the intermediate filament vimentin, staining being enhanced along with the increase in the vascular bed during the establishment of the placenta. The maternal endothelium immunoreacted to IGF-I, to both PDGF-A and PDGF receptors, to vimentin and to von Willebrand factor (Factor VIII). Desmin was also expressed in the capillary bed underneath the maternal surface epithelium. In larger blood vessels, desmin was detected in the smooth muscle layer but not in the endothelium. The vascular smooth muscle also reacted with IGF-I, PDGF-A, and PDGF-receptor antibodies. The results suggest the involvement of both growth factors, IGF-I and PDGF, in the early nutrition of the pig embryo and the tissue reorganization that encompasses placentation. IGF-I appears to be related to the secretory tissue compartment (formation of histotrophe), whereas PDGF might play a role in the reorganization of the stroma, particularly during placental angiogenesis. Desmin and von Willebrand factor immunolabelling appears to be useful to monitor the development of the subepithelial capillary bed in the porcine placenta.

Animals↗
PubMedDate not supplied

Family planning and prevention strategies for sexually transmitted diseases.

Fertility regulation and prevention of sexually transmitted diseases (STDs) are recognized pillars in fertility health work. The HIV epidemic has made it clear that there are people at risk for STDs all over the world. Both STDs and unwanted pregnancies are negative consequences of the same behavior, i.e., unprotected intercourse. From the perspective of the individual the risks with unprotected intercourse vary over time and with actual life-style. To meet the needs of the individuals the concept of contraceptive counselling needs to be expanded. Clinics where gynecologists and midwives join forces together with venerologists and social workers are being developed in Sweden. The goal for the clinics is to give an integrated message on STD and pregnancy protection.

Family Planning Services↗