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Biomedical subjects

E Quarto

Publications and source records attributed to E Quarto.

15 recordsLinked to original sources
PubMed1991

B16 melanoma response in vivo to photochemotherapy with mitoxantrone and red light.

The cytocidal activity of light-activated mitoxantrone in mice bearing B16 melanoma was investigated. Mice inoculated with 10(6) tumor cells on day 0 were i.p. injected with 1 mg/kg body weight of mitoxantrone on days 1, 5 and 9 and exposed to 108 J/cm2 of suitably filtered red light from a halogen lamp on days 2, 6 and 10. The treatment significantly prolonged the median survival time compared to both therapy with mitoxantrone and with red light alone.

Animals↗
PubMed1991

A real-time FFT analyser for monitoring muscle fatigue.

The TMS 32010 system for a real-time muscle fatigue monitor is described; it is based on mean frequency shift in the electromyographic signal (EMG). The mean frequency of the EMG is obtained, in real time, from its power spectrum, with a 2 Hz resolution. This is made possible by combining novel hardware and software.

Computer Systems↗
PubMed1990

Quantitative measurements of porphyrin pigments in tissues via photoacoustic spectroscopy.

We investigated the possibility of using photoacoustic spectroscopy as an analytical technique for the quantitative measurement of injected porphyrins in tissues. Samples of liver excised from treated (i.e., injected 24 h in advance with 100 mg/kg Photofrin II) mice and control mice were lyophilized and reduced to powder; then, about 16-mg powder samples were compacted to equal volumes inside the photoacoustic cell. Amplitude and phase spectra were measured in the range 280-760 nm. From these data we computed the photoacoustic absorbance spectra; they were suitably normalized in order to account for differences in hemoglobin concentration among the livers of different mice. The absorbance difference spectra (treated minus control) were computed in the region of wavelengths above 450 nm, where porphyrins and hemoglobin exhibit major differences. Finally, by estimating the value of the thermal diffusion length of the powdered sample and those of the extinction coefficients of the most relevant Photofrin II components in the spectral region considered, we were able to evaluate the local drug concentration and determined a value (260 micrograms/g of wet tissue) that is in the range expected for the dose of Photofrin II injected.

Acoustics↗
PubMed1982

Hemoperfusion in diabetic coma.

Hemoperfusion on ionic exchange resins in the therapy of diabetic keto-acidosis (DKA) coma is proposed. Resins used are strong anionic resins in mixed form able to release bicarbonates and to trap ketoanions and organic anions in a stoichiometric manner. A series of trials in open circuit are performed in order to search for a suitable mixture of resins and to establish the amounts of HCO3- and ketoanions respectively released or entrapped. Therefore, ten simulated hemoperfusions in closed circuit systems were performed, utilizing cartridges containing 1,700 g of mixed resin (9% HCO3- form and 91% Cl- form). The results indicate that all side effects of bicarbonate i.v. therapy of DKA coma are avoided because of the smooth HCO3- administration to the patient. Furthermore, a good removal of ketoanions and organic acids is obtained without changing the blood osmolality.

Bicarbonates↗
PubMed1980

Further studies on the realization of a cold carbon portable artificial kidney.

Optimal conditions have been determined for the realization of a closed-loop, cold carbon, portable artificial kidney to depurate the dialysate of urea and other catabolites. It has been noticed that a dialysate flow rate of about 250 ml/min represents an optimal compromise between urea mass transfer through the dialytic membrane and its mass adsorption on cold carbon. Under this condition, the use of a 2-kg carbon column to remove urea is satisfactory for a routine dialysis treatment. Our experiments have been performed on simulated dialysis. A portable cold carbon artificial kidney requires a cooling unit and a heat exchanger to recover the power necessary to produce the 0 degrees C temperature. A flat heat exchanger, consisting of three superposed plates, with a heat exchange surface of about 0.09 m2 and a total coefficient of thermal exchange Ht, of 380 Kcal/m2-degrees C-hour has been chosen. With heat recovery, the cooling power required is 1/3 hp to allow for parasitic cold losses and the power necessary to reach a steady state. All mechanical parts necessary for heating and cooling weigh about 12 kg.

Adsorption↗
PubMed1980

Cold carbon haemofiltration apparatus.

Four uraemic patients underwent haemofiltration (HF) for two months, three times a week, with an infusion of about 20L of electrolyte solution. For another two months, HF was performed with diafiltrate reinfusion after regeneration on cold carbon and ionic exchange resins. Carbon (26.8g) and resins (10g/kg b.w) were needed. The data obtained in HF and in closed-circuit HF periods were similar, but during the closed-circuit HF treatment there was better control of acid-base balance.

Blood↗
PubMedDate not supplied

Cold carbon apparatus for hemodialysis.

A prototype of artificial kidney with regeneration of the dialysis fluid in active carbon at low temperature is presented. The data obtained through a series of simulated dialysis show that carbon adsorbs, besides creatinine and other compounds, urea in satisfactory quantities. Furthermore, the possibility of completely regenerating carbon with tap water washing makes the routine use of an artificial kidney based on a cold operating carbon depurator extremely practical.

Adsorption↗