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PubMed · 6804168

Hemoperfusion in diabetic coma.

C Giordano·R Esposito·P Bello·E Quarto·D Cirillo·M Pluvio·N Lanzetti·L Calabria
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Abstract

Hemoperfusion on ionic exchange resins in the therapy of diabetic keto-acidosis (DKA) coma is proposed. Resins used are strong anionic resins in mixed form able to release bicarbonates and to trap ketoanions and organic anions in a stoichiometric manner. A series of trials in open circuit are performed in order to search for a suitable mixture of resins and to establish the amounts of HCO3- and ketoanions respectively released or entrapped. Therefore, ten simulated hemoperfusions in closed circuit systems were performed, utilizing cartridges containing 1,700 g of mixed resin (9% HCO3- form and 91% Cl- form). The results indicate that all side effects of bicarbonate i.v. therapy of DKA coma are avoided because of the smooth HCO3- administration to the patient. Furthermore, a good removal of ketoanions and organic acids is obtained without changing the blood osmolality.

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BicarbonatesDiabetic KetoacidosisHemoperfusionHumansHydrogen-Ion ConcentrationIon Exchange ResinsOsmolar ConcentrationJournal Article

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C Giordano, R Esposito, P Bello, E Quarto, D Cirillo, M Pluvio, N Lanzetti, L Calabria. 1982. Hemoperfusion in diabetic coma.. https://doi.org/10.1159/000406180

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