PubMed Health⌕ Search

Biomedical subjects

E R Souza

Publications and source records attributed to E R Souza.

6 recordsLinked to original sources
PubMed1995

FK 506: effects on glomerular hemodynamics and on mesangial cells in culture.

FK 506 is a new immunosuppressive drug that, like cyclosporine A (CsA), presents nephrotoxicity. Glomerular hemodynamic studies showed that acute FK 506 infusion (N = 9, 3 mg/kg body wt, i.v. in bolus) caused a 57% reduction in glomerular filtration rate (GFR) (0.74 +/- 0.03 to 0.32 +/- 0.02 ml/min, P < 0.05) and a 40% reduction in single nephron glomerular filtration rate (SNGFR; 43.0 +/- 5.2 to 26.0 +/- 2.5 nl/min, P < 0.05) due to a 25% reduction in glomerular plasma flow rate (QA) (133.4 +/- 19.8 to 99.8 +/- 12.0 nl/min) and a 22% reduction in glomerular ultrafiltration coefficient (Kf; 0.1009 +/- 0.0203 to 0.0790 +/- 0.0130 nl/sec. mm Hg). After 10 days of FK treatment (N = 8, 0.6 mg/kg body wt, i.p.), we observed a reduction of 23% in GFR (0.97 +/- 0.02 to 0.75 +/- 0.04 ml/min, P < 0.05) and of 23% in SNGFR (37.9 +/- 3.0 to 29.1 +/- 1.9 nl/min, P < 0.05) due to a 42% reduction in Kf (0.1486 +/- 0.0101 to 0.0870 +/- 0.0110 nl/sec.mm Hg, P < 0.05) and a 38% reduction in QA (117.6 +/- 10.2 to 73.5 +/- 6.1 nl/min, P < 0.05). The latter was consequent to the increment of 72% in total arteriolar resistance (RT) (3.1 +/- 0.2 to 5.2 +/- 0.5 +/- 0.5 10(10).dyn.sec.cm-5, P < 0.05). Thus, the pattern of FK 506 effect on glomerular hemodynamics was similar in both acute and chronic treatments.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1976

A screening method for protein characterization and differentiation.

A circular paper chromatographic method was developed for the separation of the amino acids in proteins into 7 subgroups. Butanol-acetic acid water (4+1+1) was used as the developing solvent. Eluted ninhydrin-stained aminograms gave rise to graphic profiles or numerical indexes based on absorbance percentages. The profiles can be used to compare protein-containing samples. Twenty different samples were studied through 190 comparisons of graphic profiles and coefficients of correlation, with only 4% misleading results. The method showed excellent reproducibility for the identification or differentiation of proteins and has the advantage of being performed with low-priced apparatus and reagents.

Amino Acids↗
PubMedDate not supplied

[Evaluation of outpatient care for people with HIV/AIDS in Rio de Janeiro, from the user's perspective].

This article analyzes perceptions by people with HIV/AIDS towards five specialized units under the State Health Department, Rio de Janeiro, concerning the care provided there. The research was based on both quantitative and qualitative methods. Data from 228 questionnaires and 19 semi-structured interviews were analyzed. The results generally indicated a positive evaluation on the part of this group of health care users. One conclusion was that the positive evaluation was actually related to the quality of the services available to them. However, users seem to have low expectations toward the level of services public clinics generally provide.

Acquired Immunodeficiency Syndrome↗
PubMedDate not supplied

[Morbidity due to violence against children and adolescents in Rio de Janeiro].

An analysis of police records was carried out in the Programatic Areas (Aps) of the city of Rio de Janeiro in 1990. 8000 non-fatal records were investigated, covering children and adolescents from 0 to 19 years old. These violent events were categorized as traffic accidents, physical abuse, robbery/theft and attempt of robbery/theft, sexual abuse, extortion/sequestration, threat, neglect-abandon,drugs use/traffic, and attempt of suicide/homicide. The aim of this paper is to identify the most frequent type of violence in the different Aps. According to the findings, traffic accidents, physical abuse and robbery/theft are the most common violent events affecting, especially boys in 10-19 age group. The APs 1 and 3.3 show the highest rates. The article concludes with difficulties and possibilities of dealing with violence in the health field, especially in the professional training.

English Abstract↗