Biomedical subjects

E Raik

Publications and source records attributed to E Raik.

30 records · Page 2Linked to original sources

PubMed1976

Changing clinical, morphological and immunological patterns in chronic lymphocytic leukaemia.

Two cases of chronic lymphocytic leukaemia are presented in which, in the terminal phase of the disease, a population of abnormal lymphocytes similar to those seen in lymphosarcoma cell leukaemia replaced the morphologically normal small lymphocytes observed previously. Immunologically, this change coincided with a striking alteration in the pattern of surface immunoglobulin markers. In both cases, most cells initially carried IgM and in both cases these were replaced by cells carrying IgG as the number of abnormal lymphocytes increased. In addition, the use of anti-delta antiserum in the second case revealed the coexistence of large numbers of IgD-bearing lymphocytes as well. Calculations showed that more than half the cells present at that time must have been carrying both IgD and IgG surface markers.

Cell Membrane↗

PubMed1975

The incidence of Australia antigen in hospital staff members.

A survey of Sydney Hospital staff members for Au antigenaemia was performed during a six-month period in 1972. Nine hundred and forty-six staff members were tested by the immunoelectroosmophoresis (IEOP) method and two asymptomatic chronic carriers were detected. Subsequently, it has been hospital policy to test all new staff members. Eight hundred and ninety additional sera from staff members were obtained and 12 were found to be Au positive. Of these, only one had evidence of liver disease. The results show a slight increase in the incidence of Au positivity in hospital staff members as compared with that of the general Australian population. However, in our series the majority of chronic carriers were immigrants from countries with known high incidence of Au antigen positivity. We therefore postulate that this increase is due not to the hospital environment, but to the carrier's country of origin.

Australia↗

PubMed1975

Erythroid toxicity of azathioprin. Macrocytosis and selective marrow hypoplasis.

In a population of 70 stable renal allograft recipients receiving azathioprine, macrocytosis was present in a majority and its severity was related to azathioprine dosage. There were associated megaloblastoid marrow changes which could not be related to serum folate or vitamin B12 concentrations. Two cases of selective red cell hypoplasia in renal allograft recipients are described; in each patient, azathioprine was incriminated and the effect dose-related. These observations indicate that the erythroid effects of azathioprine may precede, and be independent of, its effects on the myeloid series.

Adult↗

PubMed1973