Biomedical subjects
E Rodríguez
Publications and source records attributed to E Rodríguez.
[Effect of octanoic acid on the insulin secretion in response to glucose in vitro (author's transl)].
The effect of octanoic acid (1.5 mM) on insulin secretion in 4.4 and 16.7 mM glucose stimulation has been studied in rat's isolated and perfused pancreas. The absence of octanoic acid does not produce any significant insulin secretion increase in response to 4.4 mM glucose infusion, whereas its presence produces a significant insulinic response of a monophasic nature. Both in the presence and absence of octanoic acid, the 16.7 mM glucose-stimulation produces a biphasic insulin secretion. The octanoic acid enhances both the first and the second phase of insulin secretion. The present results show that octanoic acid clearly potentiates the insulin secretion in response to 4.4 mM and 16.7 mM glucose.
The role of sesquiterpene lactones in contact hypersensitivity to some North and South American species of feverfew (Parthenium-Compositae).
Sixteen taxa of the genus Parthenium from North and South America and 20 sesquiterpene lactones derived from plants of the Compositae family were used for patch testing six volunteers who were known to be contact sensitive to plants and lactones of this family. The patterns of cross-sensitivity and structure-activity relationships of the allergenic lactones are evaluated and the clinical and ecological relevance is discussed.
Dermatologically active sesquiterpene lactones in trichomes of Parthenium hysterophorus L. (Compositae).
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Inhibition of the glucose induced insulin release by somatostatin in the isolated perfused rat pancreas. Action of cyclic AMP, glucagon and glibenclamide.
Insulin release in the perfused isolated rat pancreas was measured after stimulation with 16.5 mM glucose with and without somatostatin (cycle form, 100 ng/ml) in the medium. A complete blockage of the typical biphasic pattern of insulin release ocurred with somatostatin in the medium. Such blockage was abolished when cAMP (2.5 mM) and a 0.5 ml solution of glucagon (1 mg/ml) were continuously perfused for 20-minute periods and for 30-second periods correspondently. It did not take place when glibenclamide (HB-419) was perfused for a 20-minute period at a rate of 10 mug/ml. The results suggest that the adenylcyclase dependent mechanisms of glucose-induced insulin release are involved in the inhibition of the glucose-induced insulin secretion by somatostatin.
Goodpasture's syndrome: report of a case documented with electron microscopy and immunofluorescent studies.
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[Urinary steroids in the thyroidectomiced rat (author's transl)].
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[Maximum grade carotid-cavernous fistula cured by ligation of the carotid artery in the neck].
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Adrenotrophic action of ACTH in thyroidectomized rats.
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[Surgical technic in repairing the biliary tract].
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Penicillinase in urine with high bacterial counts.
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Studies on several genetic hematological traits of the Mexican population. XIV. Serum polymorphisms in several indian tribes.
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[Neurologic manifestations of vitamin B12 deficiency].
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Benign regenerative nodules with copper accumulation in a case of chronic Budd-Chiari syndrome: CT and MR findings.
Budd-Chiari syndrome is a rare disease characterized by hepatic outflow obstruction due to different causes. Hepatic nodules in patients with Budd-Chiari syndrome are rare and can be due to hepatocellular carcinoma and benign regenerative nodules. Imaging descriptions of regenerative nodules in cirrhotic livers are numerous, but the imaging findings of benign regenerative nodules associated with Budd-Chiari syndrome have only recently been reported. We present the computed tomographic and magnetic resonance features of benign regenerative hepatic nodules with copper accumulation in a patient with chronic Budd-Chiari syndrome.
Aortic dissection presenting as acute pancreatitis: CT diagnosis.
A 42-year-old male developed epigastric pain and elevation of serum amylase of 2045 U/L. A contrast-enhanced abdominal CT disclosed inflammatory changes involving the pancreas and peripancreatic tissues and findings indicative of aortic dissection. The possibility of aortic dissection should be considered in the management of patients with acute pancreatitis.
MR findings in hereditary spherocytosis.
The magnetic resonance findings of intrathoracic extramedullary hematopoiesis associated with bone marrow reconversion, and reticuloendothelial hemosiderosis in a 50-years-old are reported. Radiologic finding of extramedullary hematopoiesis was the first step to the diagnosis of previously unknown hereditary spherocytosis.
MRI of pseudocoarctation of the aorta: morphological and cine-MRI findings.
We report a case of pseudocoarctation of the thoracic aorta diagnosed by magnetic resonance imaging. Morphological spin-echo findings and cine-MRI performed by gradient-echo multiphase images are reported. No other more invasive examinations were needed to establish the diagnosis of pseudocoarctation and to differentiate from other aortic abnormalities.
Value of MR findings in predicting the nature of the soft tissue lesions: benign, malignant or undetermined lesion?
OBJECTIVE: To evaluate the value of each MRI findings in differentiating the nature of soft tissue lesions. SUBJECTS AND METHODS: We performed a blind retrospective review of MR imaging in 65 consecutive soft-tissue lesions (cystic lesions in or around the joints, and the soft tissue abnormalities directly related to a known trauma were excluded). Morphology and signal intensity characteristics were analyzed. Each lesion was considered as benign tumor malignant tumor, benign but locally aggressive lesion, and undetermined. The final diagnosis was established pathologically (n = 45), and by the association of other imaging studies, clinical findings and follow-up over 2 yr (n = 20). RESULTS: Involvement of one compartment was equal in malignant (57.1%) and benign (56.2%) tumors, whereas multicompartmental involvement was most common in non-tumoral lesions (39.1%) (P < 0.05). Well-defined margins were most frequent in benign tumors (189.2%) (P < 0.05). The change from homogeneous to heterogeneous pattern on T1- and T2-weighted sequences as a predictor of malignancy showed a sensitivity of 77.7% and a specificity of 20%. Based on the MRI findings a diagnosis of benign lesion was established with a sensitivity of 60.7% and a specificity of 77.7%; malignant tumor with a sensitivity of 78.5% and a specificity of 96% and benign locally aggressive lesions with 54.5% and 88.1%, respectively. With the addition of the clinical data, an etiologic diagnosis was performed in 78.5% benign tumors, in 85.7% malignant tumors, and in 95.6% benign non-tumoral lesions. Undetermined lesion was diagnosed in eight masses. CONCLUSION: Soft tissue lesions can be diagnosed with certainty in many benign tumors based on the integrated evaluation of morphology and signal intensity MR findings. The association of MR and clinical data allowed us to identify benign but locally aggressive lesions, mostly related to infection. MR findings are highly specific for malignant tumor, although a histologic diagnosis cannot be performed based only on image analysis. When a mass is undetermined and no criteria for benignity or malignancy can be established, pathologic analysis should be always performed.