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Biomedical subjects

E S Kiseleva

Publications and source records attributed to E S Kiseleva.

At least 55 records · Page 3Linked to original sources
PubMed1983

[Cell kinetics of oral cancer during gamma teletherapy in combination with the administration of metronidazole].

Proceeding from the clinical observation of 11 patients with cancer of the tongue, oral mucosa and stomatopharynx who received gamma-beam therapy according to the scheme of dynamic fractionation combined with metronidazole, it has been concluded that the drug enhances the degree of radiation injury of the above tumors. It is expressed in early time (the 2nd day of treatment) and a low dose level (8 Gy) at which tumor resorption starts and the completeness of gamma-beam therapy in summary doses of 30-60 Gy is revealed (a general index of a clinically complete resorption is 90.8% - 10 out of 11 patients). A simultaneous study of the proliferative activity on the biopsies from the same 11 patients has shown that tumors of the oral cavity contain a considerable amount of nonproliferating cells that reduces in the process of radiotherapy combined with metronidazole. No correlation was found between the initial content of these cells, the degree of its decrease during radiotherapy combined with metronidazole and the completeness of resorption at the end of radiotherapy.

Administration, Oral↗
PubMed1982

[Combined treatment of rectal cancer].

The comparative analysis of two methods of treatment (a combined method with the preoperative radiotherapy and a purely surgical one) of 363 patients with carcinoma of the rectum has shown that an intensive concentrated course of radiotherapy with irradiation of extended fields (the irradiation zone includes the small pelvis cavity and paraaortal lymph nodes up to the level of the second lumbar vertebra) is satisfactorily endured by the patients and does not complicate the operation. In the postoperative period the patients subjected to preoperative radiotherapy showed a longer healing of the perineal wound. The authors failed to reveal any difference in the results of a 3-year survival of the patients after the combined and purely surgical methods of treatment. Local recurrencies were found to be less frequent following the combined method.

Humans↗
PubMed1982

Proliferative activity and radiosensitivity of human tumors.

On surgery material and biopsies from human tumors of various types investigation of labeling index and growth fraction in vitro, cell survival and cell population kinetics in diffusion chambers and changes in the cell kinetic parameters after irradiation were performed. The analysis of results obtained using the diffusion chambers and in vitro system demonstrate variability in labeling index within tumors of various type, individual differences and variation within the same tumor. Significant variability of growth fraction in individual tumors was also noted, however, in many instances, the most of cells in tumor were not proliferating. The growth fraction in gliomas and tumors of the floor of mouth was greater in tumors with high labeling index, in patients with a short tumor history and in patients with the short nonrelapse period. In the same groups of tumors changes of labeling index growth fraction during radiotherapy were compared with the therapeutic response of tumors. It can be concluded that the initial parameters of proliferative activity (labeling index and growth fraction) did not determine the radiation response of tumors but the dynamics and the intensity of their changes during the treatment were more informative in this respect. Complete regression of tumor may be expected only with decrease of labeling index and growth fraction.

Cell Division↗
PubMed1978

[Development of combined methods of treatment of malignant tumors].

The term "combination treatment" should implicate various methods of treatment for malignant tumors scheduled beforehand. The combination treatment of malignant tumors is aimed at improving the immediate and late results. This is gained by means of reducing the biological activity of a tumor, both the effect of summation and potentiation of the action of different therapeutic measures being observed. The choice of methods and their sequence is determined by the prognosis factors, which incude the histological tumor structure, anatomical type of growth, the degree of its proliferation both within the range of proximate and remote zones of metastases spread, the general patient's state. At this stage it is difficult to elaborate the methods of combination treatment. The difficulties are conditioned by a variety of forms of many solid tumors, methodical difficulties and complexity of estimating an efficacy of different variants of treatment. Accumulating of knowledge should determine the a range of lesions subject to the combination treatment.

Academies and Institutes↗