[Evaluation of therapeutic efficacy in neurology].
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Biomedical subjects
Publications and source records attributed to E Salerni.
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We report the results of an epidemiologic study in the Municipality of L'Aquila, Abruzzo, Central Italy, undertaken to estimate the prevalence rate of Multiple Sclerosis (MS). On December 31, 1984, the prevalence was 33.2 per 100,000 (34.2 when age and sex is standardized to the Italian population). In agreement with recent intensive surveys from different regions in the North and South of Italy, our data indicate that the prevalence of MS in Italy is higher than 30 per 100,000, and emphasize the importance of small population studies in the epidemiology of MS. Our findings suggest that in Italy the risk for MS is higher than recorded before.
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Serial analyses of peripheral blood T-lymphocyte subsets were performed in 280 samples collected over a 27 months period from 14 multiple sclerosis patients. A significant decrease of T8+ cells was found in 47.1% (47/87) of blood samples collected within four weeks of onset of a relapse opposed to 2.1% (1/47) of samples collected during the four weeks before a relapse and to 3.4% (5/146) of those collected over four weeks after a relapse. Changes of T-cells subsets appear to correlate with disease activity, but normal findings observed before relapses suggest that the decrease of T8+ cells cannot be used as valid predictor of relapse.
Clinical and histopathological data of a patient affected by myotonic dystrophy (Steinert Disease) and multiple pilomatrixomas (calcifying epithelioma of Malherbe) are reported. This association has been previously reported in other 16 cases. The prevalence of pilomatricoma in myotonic dystrophy results much greater than in general population. This association affects females as well as males. This tumour, when associated with myotonic dystrophy, is more frequently multiple than single.