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Biomedical subjects

E Sawicka

Publications and source records attributed to E Sawicka.

At least 19 recordsLinked to original sources
PubMed2005

Styrene and ethylene glycol have a synergetic effect on lipid peroxidation that is better protected than repaired by CoQ10.

Previous study of a group of 22 workers occupationally exposed to styrene, ethylene glycol and their mixture at a paint and lacquer industry indicated significantly elevated concentration of malondialdehyde with 4-hydroxynonenal (MDA+4-HNE) in the blood plasma, successfully decreased with coenzyme Q10 (CoQ10) supplementation. The aim of present study is to evaluate whether the exposure to styrene or/and ethylene glycol could be responsible for the increase in MDA level. The mechanism of a single solvent action and the mixture was examined, specially whether it is connected with hydroxyl radical (*OH) generation. It was also investigated whether coenzyme Q10 could be considered as a protective (given before the solvents) or repairing (given after the solvents) agent in oxidative stress caused by the solvents. The results indicate that ethylene glycol nor styrene increase MDA and *OH, but as a mixture give synergetic interaction, elevating MDA and *OH concentration to a statistically significant extent. Coenzyme Q10 at a dose of 3.0 microg/ml only protects, but does not repair increased lipid peroxidation caused by ethylene glycol with styrene. In order to obtain both a protective and repairing effect, a concentration of 12.0 microg/ml CoQ is needed.

Coenzymes↗
PubMed2004

Oxidative stress and coenzyme Q10 supplementation in renal transplant recipients.

Recently some reports about the oxidative stress in renal transplant recipients have been published. The role of coenzyme Q10 (CoQ10) as radical scavanger is largely known. The aim of our study was to evaluate the protective role of CoQ10 in renal transplant recipients on lipid peroxidation and lipids parameters, as well as its influence on antioxidant enzymes, neutrophils chemiluminescence and urinary enzymes. The study was performed in 11 long term allograft recipients treated additionally with CoQ10 90 mg/day in three doses, 30 mg each for four weeks. The malonyldialdehyde (MDA) and 4-hydroxynonenal (4-HNE), superoxide dismutase (SOD) and glutathione peroxidase (GPx) and the basic parameters of lipid metabolism such as total cholesterol (TC), high and low density lipoproteins (HDL, LDL), triglycerides (TG), atherogenicity indicators [LDL/HDL; (TC-HDL)/HDL] were evaluated. The chemiluminescence of neutrophils (luminol, fLMP-method) were mesured and the activity of N-acetyl-beta-D-glucosaminidase (NAG), alanylaminopeptidase (AAP), elastase, alpha-1-antitrypsin. All parameters were estimated before and after CoQ10 treatment. Statistically significant changes were noticed with the LDL and atherogenicity indicators (p < 0.01) (decrease) as well as HDL level (p < 0.001) (increase). Also the significant decrease of fMLP stimulated PMNL chemiluminescence (p < 0.05) confirms the antioxidative properties of CoQ10. The significant increase of NAG activity (p < 0.05) can't be the result of nephrotoxic effect, because NAG-B is unchanged. Serum concentration of creatinine and cyclosporine A in renal allograft recipients was unchanged after CoQ10 treatment. The presented date shows that further study with CoQ10 treatment in renal transplant in larger numbers and over longer periods should be considered.

Acetylglucosaminidase↗
PubMed1999

Enzymuria in antibiotic therapy of acute infections.

Activities of N-acetyl-beta-D-glucosaminidase (NAG), its isoenzyme NAG-B, alanylaminopeptidase (AAP), elastase and trypsin inhibitor (alpha 1 PI) were evaluated as markers of nephrotoxicity and inflammation in acute infections treated with various antibiotics (vancomycin, netilmicin, pefloxacine, cefoperazone and imipenem).

Acetylglucosaminidase↗
PubMed1998

The chemoprotective effect of coenzyme Q on lipids in the paint and lacquer industry workers.

The influence of coenzyme Q on the lipid parameters in the paint and lacquer industry workers is presented. The examinations were carried out in the group of 24 workers employed at the paint and lacquer production, who received coenzyme Q10 as a chemoprotective agent. Serum concentration of basic lipid parameters: total cholesterol (TC), high density lipoproteins (HDL), low density lipoproteins (LDL), triglycerides (TG); lipid peroxidation products: malonyldialdehyde (MDA) together with 4-hydroxynonenal (4-HNE) and two antioxidant enzymes: superoxide dismutase (SOD) and glutathione peroxidase (GPx) were examined. The above parameters were measured in workers exposed to organic solvents and then after 4 weeks of coenzyme Q treatment. In order to explain, whether the occupational exposure is responsible for the changed level of some parameters, the reference group, not employed in the paint and lacquer industry, was used. The results indicated that the preliminary blood serum concentration of MDA + 4-HNE in workers exposed to organic solvents was significantly elevated in comparison to the control group. Statistically significant decrease in MDA + 4HNE concentration was observed after coenzyme Q treatment what lead to the conclusion that coenzyme Q could be considered as a protective agent against lipid peroxidation in occupational exposure. The changes in other parameters were statistically insignificant.

Adult↗
PubMed1991

Origin of the ring muscle fibers in neuromuscular diseases.

Morphological histochemical and ultrastructural examination of the ring fibers in one case of myotonic dystrophy and one case of mitochondrial myopathy provides evidence that the ring fibers develop in the course of fiber splitting and reinnervation of muscle fiber fragments. The reinnervation may have been due to a neurogenic lesion coexisting in both cases with the myopathic picture. The histologically different type of annular myofibrils observed in one case of cap disease is probably due to delayed embryonic development and abnormal relations between the myofibrils and elements of the cytoskeleton.

Adenosine Triphosphatases↗
PubMed1989

[Comparative studies of cyclic 11, 12 erythromycin carbonate (davercin) and erythromycin a levels in lung tissue, serum and bronchial secretions].

A comparison of serum, pulmonary tissue and bronchial secretory levels of erythromycin and cyclic--11,12 carbonate of erythromycin (Davercin--Polfa) was carried out in 55 patients with lung cancer. All patients received erythromycin and Davercin 80 hours prior surgery, during which a small fragment of pulmonary tissue was removed for further evaluation. Concentration of both antibiotics was determined microbiologically. Better penetration of Davercin to the pulmonary tissue was found, as well as higher tissue concentration. The study demonstrates the advantage of Davercin over erythromycin in treating bacterial infections of the respiratory system.

Body Fluids↗
PubMed1987

Progressive supranuclear palsy with lower motor neuron involvement. A case report.

The clinical picture of progressive supranuclear palsy is relatively constant, including supranuclear ophthalmoplegia, pseudobulbar palsy, axial dystonia in extension, parkinsonian signs, postural instability and dementia. A case is reported, which is unusual in having flexor dystonia of the neck and marked signs of lower motor neuron involvement.

Aged↗
PubMed1981

Spinal cord damage as a complication of renal artery embolization in patients with renal carcinoma.

The authors report three cases of complications of renal artery embolization in patients with renal carcinoma. In two cases renal artery embolization was followed by paraparesis with loss of sphincter control. In these cases nephrectomy was performed on the side of the neoplasm and neurological disturbances disappeared after pharmacological treatment and rehabilitation. The third patient was not treated surgically. Embolization was followed by development of spinal cord damage at the level Th12. The patient died of neoplastic cachexia and cardiorespiratory failure.

Aged↗
PubMed1980

Correlative biochemical and morphological studies of myelination in human ontogenesis. I. Myelination of the spinal cord.

Biochemical, light and electron microscopic observations in six human fetuses between the 16th and 34th weeks of gestation and five infants, 1 day to 3 years old, are presented. The results indicate that myelination of the human spinal cord started before the 16th week of gestation, as a considerable amount of myelin is isolated at this time biochemically, and occasionally axons with loose myelin coils are observed in the electron microscope. It is also stressed that morphological studies are insufficient to evaluate the completion time of the myelination process, as it can be shown biochemically that qualitative myelin maturation takes a long time.

Axons↗
PubMed1980

Correlative biochemical and morphological studies of myelination in human ontogenesis. II. Myelination of the nerve roots.

Biochemical and morphological observations of nerve roots in six fetuses from the 16th to 34th week of gestation and five infants 1 day to 3 years old are presented. In dorsal roots the process of myelination begins later than in the ventral roots and spinal cord and proceeds much slower. As in the spinal cord during nerve roots myelin maturation profound lipid changes are observed.

Child, Preschool↗
PubMed1979

[Case of hereditary sensory neuropathy with atypical clinical course].

The authors report cases of hereditary sensory neuropathy of atypical clinical pattern in siblings. Besides evident sensory disturbances signs of peripheral motoneuronal damage and cerebellar signs were present. Electrophysiological and histological investigations in one of these cases confirmed that sensory disturbances were connected with damage to the peripheral sensory neuron.

Adult↗