PubMed Health⌕ Search

Biomedical subjects

E Sudmann

Publications and source records attributed to E Sudmann.

At least 55 records · Page 3Linked to original sources
PubMed1980

Anterior displacement of the tibial tuberosity in the treatment of chondromalacia patellae.

Anterior displacement of the tibial tuberosity combined with shaving of the diseased cartilage was used as treatment for chondromalacia patellae in 32 knees in 28 consecutive patients and in one patient with chondromalacia femoris. The patients were aged 17 to 57 years. One patient had earlier sustained a serious injury to the ligaments of the knee, resulting in instability. All patients except one were unfit for work before the operation. Postoperative extra-articular wound infection was noted in two knees and venous thrombosis occurred in three legs. The postoperative observation period varied from 8 months to 2 years and 10 months. In one knee the anterior displacement of the tibial tuberosity was not maintained. In lateral radiographs the anterior displacement of the tibial tuberosity in the other knees varied from 10 to 23 mm. The relief from pain obtained by the operative treatment was estimated as good in all knees except three, which were unchanged. All patients became fit for work and/or sport.

Adolescent↗
PubMed1979

Mixed-image longitudimetry: a new method of length measurement in microscopy.

A simple and inexpensive instrument called a longitudimeter for measuring distances in microscopy was constructed from a precision map-measuring device and an electric lamp positioned eccentrically on a stand. A precision better than 1% was readily obtained in measurements of the perimeters of trabecular surfaces in cancellous bone. Mixed-image longitudimetry was devised for length measurements in cancellous bone, but the method seems suitable for a wider application in quantitative microscopy.

Bone Lengthening↗
PubMed1979

Inhibition of fracture healing by indomethacin in rats.

The effect of indomethacin (2 mg/kg/day) on the healing of closed unimmobilized femoral fractures was examined in rats. A standard femoral fracture was produced in 205 male adolescent rats, and three different experiments were done. In a long-term experiment, the rats were treated with either indomethacin or placebo for 29 days and fracture healing followed for a maximum of 91 days. In two short-term experiments, the rats were treated with either indomethacin or placebo for a week and followed for a maximum of 122 days. The effect of age was studied in one experiment. Indomethacin plasma levels were about 1 microgram/ml in the indomethacin-treated animals. In the long-term experiment, indomethacin inhibited fracture healing (P less than 0.006) and increased the angulation between the femur fragments. In the short-term experiments indomethacin inhibited fracture healding (P less than 0.033) and increased the interfragmentary angle as well as fracture instability. All untreated fractures healed within 10 weeks in younger rats (210 g), whereas only 44% healed in older rats (295 g).

Animals↗
PubMed1979

Treatment of chronic osteomyelitis by free grafts of cancellous autologous bone tissue. A preliminary report.

Chronic osteomyelitis was treated by free grafts of autologous bone tissue in 13 consecutive patients aged 18 to 81 to years. In all patients the osteomyelitis was located in the leg, and Staphylococcus aureus was the causative organism. Seven had an infected non-union. The duration of the osteomyelitis varied from less than 1 year to 75 years. Surgical debridement and grafting of cancellous and cortical cancellous bone were performed at the one operation. The osteomyelitis healed after a single operation in all patients but one, who needed three operations before the infection was eradicated. In one patient a second bone grafting operation was necessary before weight-bearing could be allowed. Although the number of patients is small, the results agree well with larger series published recently. Grafting of autologous bone tissue seems to be a very valuable method of treatment for chronic osteomyelitis.

Adolescent↗
PubMed1979

The painful chronic anterior lower leg syndrome. A prospective clinical and experimental study.

A presumed painful chronic anterior lower leg syndrome was diagnosed in 51 patients (73 legs), 30 women and 21 men, aged 11 to 70 years, over a 2-year period. The duration of the syndrome varied from 1 month to 10 years. The patients' main complaint was pain when walking located in the medial ventral muscle compartment of the lower leg. In addition 10 of the patients (15 legs) had leg pain at rest as well and 12 (15 legs) had paresis of the extensor muscles. Thirty-four paired intracompartmental pressure recordings with the wick technique in 6 patients suggest that the more severe the syndrome the lower the pressure in the tibialis anterior muscle. Blind diathermic fasciotomy in 25 patients (36 legs) with a typical history relieved the pain and paresis completely or partly in 33 (92 per cent) out of 36 legs. No postoperative complications worth mentioning were observed. It is concluded that: 1) a chronic painful anterior lower leg syndrome should be suspected in patients with pain on walking and at rest located in the ventral part of the lower leg; 2) intracompartmental pressure measurements seem to be of little preoperative diagnostic value in non-selected patients; 3) blind diathermic fasciotomy of the anterior, medial compartment of the lower leg, including the extensor retinaculum, gives relief from pain and paresis in most patients with a typical history.

Adolescent↗
PubMed1979

Indomethacin-induced inhibition of haversian remodelling in rabbits.

The effect of indomethacin on haversian remodelling in the radius was studied in 16 rabbits. An osteotomy and a saw-cut almost through the bone were made in the middle and distal parts of the right radius, respectively. In order to obtain biological osteosynthesis in the osteotomy and the saw-cut the rabbits were not treated in any way during the following 3 weeks. They were then given either indomethacin or placebo suspensions per os, 10 mg/kg/day for 2 weeks, followed by 5 mg/kg/day for 4 weeks. The extent of haversian remodelling was estimated by calcein and oxytetracycline fluorochrome labels given at the start of the indomethacin treatment and 3 weeks later, respectively. After 2 weeks of indomethacin treatment (10 mg/kg/day) the indomethacin plasma levels were about 0.18 microgram/ml 24 hours after the last dose. Indomethacin treatment significantly (2P less than 0.019) inhibited haversian remodelling as estimated by fluorochrome labelling.

Animals↗
PubMed1976

Indomethacin-induced delayed fracture healing.

A patient with an ankle joint fracture-dislocation was preoperatively treated with indomethacin. As in previous animal experiments, indomethacin was found to have an inhibitory effect on bone formation. It is suggested that indomethacin should be used with caution if periosteal fracture healing is anticipated.

Ankle↗
PubMed1976

Effect of indomethacin on fracture healing in rats.

The healing of closed, non-immobilized femoral fractures in rats was seriously impaired by indomethacin given orally at a dose of 2 mg/kg daily. The fracture haematomas were larger and disappeared later in the animals receiving indomethacin. Mechanical strength testing of fracture healing showed that maximal tensile strength, elastic stiffness and maximal bending moment between fragments were significantly diminished in the indomethacin-treated animals. Radiological examination showed a smaller amount of mineralized callus and a more pronounced angulation between the fragments in these animals than in the placebo-treated ones. Hsitological examination showed bridging between the fragments by callus tissue 24 days after fracture in placebo-treated animals, whereas indomethacin treatment was followed by histological findings resembling those seen in early pseudarthrosis development.

Animals↗
PubMed1975

Mixed-image planimetry. Assessment of a new method for stereometric analysis in microscopy.

A new method for stereometric measurement of surface area in microscopy is described, based on the mixed-image principle. The measurement was accomplished by observing the area on which was superimposed the image of a miniature electric lamp attached to an ordinary planimeter. Mixed-image planimetric measurements were more easily made and required much less time than area calculation by an integrating eyepiece, by weight or by ordinary planimetric measurements of photomicrographs or tracings of the area. Mixed-image planimetric measurements of a finite area varied less than 1 per cent. Such precision was not obtained with the other methods. The new method was devised in vivo stereometric measurements of bone tissue remodelling in rabbit ear chambers, but should find a much wider application in quantitative microscopy of both finite and extensive objects.

Animals↗
PubMed1975

A novel titanium rabbit ear chamber for vital microscopy of bone tissue.

Seventy-eight small titanium-glass culture chambers of own design for vital microscopy of bone tissue were inserted in the ears in 41 rabbits. After insertion without removing the cartilage on the inner side of ears not previously operated upon, 44 out of 56 chambers (79 per cent) became vascularized. It proved satisfactory for bright field, fluorescence and polarized light microscopical observations of living bone tissue for half a year or longer.

Animals↗
PubMed1975

Osteogenesis in rabbit ear chambers.

Heterotopic osteogenesis was studied in vivo by grafting 246 bone tissue grafts onto 39 cultures chambers inserted in the ears of 27 rabbits. Bone formation was obtained from 23 out of 24 autografts placed inside the optical part (greater than 0.1 mm deep) of 8 ear chambers. No bone tissue formation was observed in the optical part (less than 0.1 mm deep) of 23 chambers in which a total of 129 autografts had been placed in a communicating deeper non-optical part. Bone formation was always obtained after autografting bone tissue to the non-optical part of a titanium-glass ear chamber of own design, and bone tissue entered the optical part of these chambers when this was deeper than 0.1 mm. The possible source of bone formation in rabbit ear chambers is mentioned. Resorption of bone tissue autografts was regularly obtained.

Animals↗
PubMed1975

Bone remodelling in rabbit ear chambers. A vital microscopical and histological study.

Heterotopic autologous bone tissue was studied by vital microscopy in rabbit ear chambers and correlated with the findings from histological sections prepared from the same tissue. The in vivo morphology and remodelling of different bone types were thereby characterized. Autografts were resorbed in a disordered fashion by osteoclasts and woven-fibred bone tissue formed on such grafts. Later parallel-fibred bone, bounded by a seam of osteoid tissue, formed on this scaffold. Bone flakes growing underneath the cover glass were remodelled into shallow hemi-ossicles containing fat marrow, which were always oriented towards the cover glass. Following en bloc removal of the central part of the bone culture, woven-fibred bone rapidly formed within the new connective tissue, filling in the empty space. Such bone was remodelled into cancellous bone containing fat marrow. A balance between resorption and formation was regularly established in the chambers. The bone cultures were thus useful for vital microscopical studies for half a year or longer. In the present study bone remodelling in rabbit ear chambers closely resembled that of orthotopics bone. Ear chamber bone cultures are therefore a versatile in vivo biological model for dynamic bone tissue studies at both tissue and cellular levels.

Animals↗