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E V Filatova

Publications and source records attributed to E V Filatova.

At least 19 recordsLinked to original sources
PubMed2006

[Blocks of neuron correlates of behaviour in the monkey brain prefrontal cortex and striatum].

The dynamics of tonic neuron activity of the putamen and prefrontal cortex of monkey's brain is researched by studying sequential stages of executive behavior program. It is determined that tonic responses in both structures are classified in separate blocks. The blocks are timed to key moments of behavior connected with intermediate goals framed by a common task. As to the structures of the aforesaid blocks of tonic activity in cortex and striatum, they are different in instructive part of the program and similar in executive one. More differential attitude of cortex is revealed to the sequence of executive behavior activity.

Animals↗
PubMed2005

Neuron activity in the monkey striatum of identifies integration sequential actions into functional blocks.

Spike activity in monkey striatum (putamen) neurons was recorded during the performance of a complex multistep operant task. Tonic responses propagating beyond a single action were recorded, along with phasic responses seen within a given action. The tonic type of response was recorded in 132 of 148 cells. Only 11 of these neurons showed exclusively this type of activity. The beginnings and ends of tonic responses were generally associated with key moments in the behavior, corresponding to the triggering and completion of immediate aims during the performance of the behavioral program as a whole. These results provide evidence that the role of the striatum is not limited to controlling single sequentially performed actions, but spreads to the whole structure of a behavioral act.

Action Potentials↗
PubMed2004

Behavior-reactive neuron populations in the monkey neostriatum.

Comparative analysis of neuron activity in the monkey putamen during multistep behavior showed that putamen neurons are active during all the animal's behavioral actions. The difference between the number of active neurons at a given step of the behavior as compared with the preceding step was found to be significantly smaller than the number of neurons reorganizing their activity at this step. Reorganization of neuron activity in the putamen is regarded as a reflection of the efferent code controlling the behavior, while the extent of reorganization is regarded as a measure of the change in this code in association with the organization of a sequential behavioral action. Changes in the numbers of active neurons at different stage of behavior and reorganization of their activity occurred independently of each other. This may be associated with the two afferent systems of the striatum: that ascending from the brainstem and the corticofugal, which carries differential information to the neural network of the striatum from various parts of the cortex.

Action Potentials↗
PubMed2004

The differentiating activity of monkey putamen neurons during performance of alternative spatial selection.

Spike activity was recorded from three zones of the putamen in monkeys trained to bimanual operant activity during performance of an alternative spatial selection task. Neuron responses were analyzed using the following criteria: a) differentiation of the side providing reinforcement (differentiating/non-differentiating responses); b) response duration (tonic/phasic); c) response laterality (contralateral/ipsilateral hemispheres); d) baseline activity frequency. The differentiating activity of cells was found to show the closest correlation with behavioral aspects of the program, particularly the tonic part and, even more so, contralateral tonic responses. It is suggested that differentiating activity, as opposed to non-differentiating activity, is less a reflection of the morphological and neurochemical characteristics of the neural elements of the putamen than of their functional homogeneity in relation to external determinants of behavior.

Action Potentials↗
PubMed2004

Sequential rearrangements of the ensemble activity of putamen neurons in the monkey brain as a correlate of continuous behavior.

Simultaneous recordings were made of the spike activity of groups of 6-7 neurons in the putamen in two monkeys (Macaca nemestrina and Macaca mulatta) during performance of alternative spatial selection. Discriminant analysis was used to evaluate the magnitude of rearrangements in spike activity in groups of neurons during transitions from each step of the behavioral program to the next, along with the degree of differences in reactivity mosaics formed at each step in different versions of task execution. Rearrangements in spike activity were noted at all steps of the program. The dynamics of rearrangements on selection of the right and left feeders were different, leading to the appearance of significant differences in the reactivity mosaics at the decision-taking and reinforcement-receiving steps. The rearrangements preceding voluntary movement of one hand were more marked in the contralateral hemisphere. During performance of movements, the volume of rearrangements could increase, though differences in rearrangements accompanying movements of the right and left hands decreased. On receipt of reinforcement, rearrangements were greater when the animals selected a specified feeder (the left feeder) independently of which hemisphere was recorded.

Action Potentials↗
PubMed2004

[Neuronal activity of the monkey striatum points at the integration of successive actions into functional blocks].

In order to study the role of the striatum in generation of multistage behavior, the spike activity of 148 cells was recorded in the monkey brain putamen. Two kinds of neuron responses were observed. Phasic response involved activity during only one stage of the behavior program, and tonic response involved activity during more than one sequential stage. The tonic responses were recorded in 132 neurons out of 148, 11 neurons responding only as tonic. Other 121 cells show under different conditions both tonic and phasic responses. Beginnings and ends of "tonic" responses as a rule corresponded to the start and completion of the nearest behavioral aim. The obtained data suggest that the neuron activity of striatum is related not only to the control of individual movements but also to the whole structure of behavior.

Animals↗
PubMed2002

[Correction of central mechanisms of sanogenesis regulation in children with cleft palate].

Theoretical prerequisites for the development of new methods for treatment of children with cleft palate by physical factor exposure are presented. Morphofunctional characteristics of the central nervous system formation during the prenatal and early postnatal periods are described. A multi-level method of magnetic laser exposure of the cerebrocortical precentral gyrus and electrostimulation by the ciliary reflex system, modifying the central regulation and adaptation mechanisms during the immediate period after uranoplasty, has been developed.

Adaptation, Physiological↗
PubMed2002

[Populations of behavior-reactive neurons in the monkey neostriatum].

Comparative analysis of the unit activity of the monkey putamen during multistage behavior showed that neurons of the putamen are active during all the behavioral actions. It was established that the number of the behavior-related neurons changes considerably less than number of neurons which reorganize their activity at the time. Reorganization of unit activity in the putamen is considered as reflecting the efferent code which controls behavior, and the degree of reorganization--as a measure of change of this code in relation to organization of ongoing behavioral action. It has been discovered that the change in the number of the active neurons at various steps of behavior and reorganization of their activity occurs independently. It may be related to two main afferent systems of striatum: ascending from rhe brain stem, and corticofugal which brings differentiated information to the neuronal net of striatum from various parts of the cortex.

Action Potentials↗
PubMed2002

[Differentiating activity of monkey putamen neurons during performance of the alternative spatial choice].

Single unit activity was recorded in monkeys in three putamen zones learned a bimanual operant activity during performance of the task of alternative spatial choice. The neuronal reactions were specially analyzed by the criteria as follows: a) differentiation of the side of reward (differentiating--non-differentiating reactions); b) character of reaction by duration (tonic-phasic); c) laterality (contra- and ipsilateral reactions as related to hemisphere); d) frequency of background activity. It was shown that differentiating cell activity, especially their tonic part and in still greater degree contra-lateral tonic reactions most closely correlate with behavioral aspects of the program. The assumption that differentiating activity, unlike non-differentiating one, is the reflection of not only morphological and neurochemical characteristic features of nervous elements of putamen but of its functional uniformity in relation to external determinants of behavior, was put forward.

Action Potentials↗
PubMed2002

[Sequential rearrangements of ensemble activity of the putamen neurons of monkeys as a correlate to continuous behavior].

Simultaneous recording of unit activity of 6-8 putamen neurons in two monkeys (M. nemestrina and M. mulatta) during performance of the task of alternative spatial choice, was carried out. The extent of rearrangements of the activity in the groups of neurons with the transition from every step of the behavioral program to the next one and the degree of difference in mosaics of reactivity, forming at every step with a different variants of performance, were evaluated using discriminative analysis. The rearrangements of the impulse activity were recorded in all steps of the program. The dynamics of rearrangements with the choice of right or left feeder was different, which resulted in appearance of significant differences in mosaics of reactivity at the stage of decision making and receiving reward. The rearrangements preceding the task-oriented movement of one hand were more pronounced in the contralateral hemisphere. The volume of rearrangements may increase with the performance of movement but the differences of mosaics formed during the movement of right and left hand are decreasing. At the stage of reception of the reward, the rearrangements were greater in case the animal chose the certain (left) feeder irrespective of the side of recording the unit activity.

Action Potentials↗
PubMed2001

[New potentialities of laser therapy and electrostimulation after cheilorhinoplasty].

A method for stimulation of the central regulation mechanisms has been used in 53 patients during the early period after cheilorhinoplasty. Electrostimulation by the flickering reflex method is a nonspecific method stimulating sanogenesis which can be used for repair of the neuromuscular function after correction of secondary deformation of the upper lip and palate. Transcerebral laser stimulation indirectly affected the reparative processes in the maxillofacial area by improving metabolism in the cerebrocortical projection zones.

Blinking↗
PubMed1996

[A comparison of the effect of Capoten (captopril) and ramipril on the circadian profile of the arterial pressure and peripheral hemodynamics in patients with hypertension combined with diabetes mellitus].

20 patients with essential hypertension and diabetes mellitus (DM) type II were given Capoten (100-125 mg/day for 6 weeks) followed in a 2-week interval after its course termination by ramipril (10.0-12.5 mg/day). 50% of patients were sensitive to Capoten, 50% were resistance: 35 and 40% to ramipril, respectively. Ramipril was discontinued because of toxicity in 25% of patients. Hypotensive effects of ramipril were weaker than Capoten, though the former drug appeared more potent in lowering of peripheral vascular resistance at rest and at reactive hyperemia. Vasodilatation did not differ much.

Angiotensin-Converting Enzyme Inhibitors↗
PubMedDate not supplied

Food-procuring behavior of rats under the conditions of chronic activation and blockade of the neostriatal dopaminergic system.

Using the technique of intracerebral microinjections, the features of food-procuring behavior (the realization of a situational instrumental conditioned reflex in a Skinner box) were investigated in rats in experiments under the conditions of a pharmacological influence on the dopaminergic system of the neostriatum. Amphetamine in a dose of 15 and 45 micrograms and haloperidol in a dose of 5 mg were injected daily over the course of three weeks bilaterally into the rostral division of the neostriatum. A amphetamine dose of 15 micrograms was ineffective, but a increase in motor hyperactivity, a behavioral stereotypy, and a substantial acceleration of food-procuring movements were observed against the background of the injection of 45 micrograms of amphetamine. Stimulation of the dopaminergic system of the neostriatum qualitatively altered the behavioral strategy in animals with an initially low level of realization of the reflex; this fostered a stable activation of the instrumental skill enduring even after the cessation of the microinjections. Chronic blockade of dopamine receptors by haloperidol induced the reverse effect.

Amphetamine↗