Biomedical subjects

E Wilmes

Publications and source records attributed to E Wilmes.

76 records · Page 5Linked to original sources

PubMedDate not supplied

[Analysis of the possibility of transmitting the human immunodeficiency virus when using cartilage grafts].

Allogenic cartilage represents an important source of tissue for reconstructive surgery in the head and neck. The use of allografts is now being discussed because of the possible transmission of the human immunodeficiency virus (HIV). The purpose of this study was to investigate the susceptibility and permissivity of cartilage tissue to HIV-1, in order to analyze the possibility of a HIV-transmission through cartilage allografting.

Antibodies, Monoclonal↗

PubMedDate not supplied

[Self-expandable prosthesis for the management of cervical and thoracic tracheomalacia].

Four patients afflicted of cervical and thoracic tracheomalacia have been treated with self-expandable and elastic metal prosthesis. The implantation of this prosthesis resulted in immediate improvement of the respiratory function. Long-term follow-up of these patients (24 months) showed a very good evolution. In this paper we describe the prosthesis features, the implantation technique as well as the radiological and endoscopic results.

Aged↗

PubMedDate not supplied

[Comparative study of the effect of different chemical procedures on the antigenicity of allogenic transplants of the human trachea].

Replacement of long tracheal segments poses some unsolved problems, specially the undisponibility of an adequated substitution material. This study deals with some of the immunological aspects of the transplantation and preservation of human tracheal grafts. Since immunological rejection occurs in the first place as a consequence of incompatibility for class II antigens (HLA-DR, -DP and -DQ), their presence and distribution was studied using monoclonal antibodies and the immunoperoxidase method. Class II expressing cells were recognized in the mucosa and the mixed glandular tissue. Furthermore we investigated the influence of different preservation methods on the antigenicity of tracheal allografts. The results showed a total destruction of these antigens. We can conclude that chemically preserved human tracheal allografts are immunologically suitable for reconstructive surgery of the trachea.

Cialit↗

PubMedDate not supplied

[Cellular viability of cryopreserved cartilage grafts].

Transplantation of preserved cartilage has an important role in reconstructive surgery. Opinions vary with regard to the performance of cryopreserved cartilage. We studied the functional state of chondrocytes after cryopreservation. Cellular survival was studied using the trypan blue dye exclusion test, a functional assay for cell adhesion, and transmission electron microscopy. Most chondrocytes were irreversibly damaged by cryopreservation and the cartilage could not originate new cartilage. Therefore, cryopreserved cartilage tends to generate fibrosis and resorption and is not practical for reconstructing skeletal parts exposed to mechanical stress.

Cartilage↗