Biomedical subjects
Elsebeth Lynge
Publications and source records attributed to Elsebeth Lynge.
[Recommendations on cancer screening in the European Union. Advisory Committee on Cancer Prevention].
Explore the source record for details and available documents.
[Mammographic screening in the municipality of Copenhagen 1991-1997. Evaluation of the preoperative assessment].
INTRODUCTION: A biennial mammography screening programme started for all women aged 50-69 in the municipality of Copenhagen, Denmark, in April 1991. The aim of the present study was to evaluate the quality of the preoperative diagnostic assessment for women recalled for further examination. Quality indicators were: validity of the fine-needle aspiration cytology, rate of malignant to benign surgery, and frequency of one-step surgery for malignant lesions. MATERIAL AND METHOD: Database registries during the first three screening rounds from April 1991 to March 1997 were studied retrospectively, for fine-needle aspiration cytology tests where surgical biopsy was also performed. RESULTS: In the period 1991-1997, 4,111 women were recalled for clinical mammography and subsequently 1,086 women underwent surgery. The use of the triple test in the preoperative assessment increased from 50% in the first screening round to 72% in the third. Throughout the period of evaluation, the number of inadequate fine-needle aspiration cytology (FNAC) was reduced from 32% to 6%. Inadequate FNAC from malignant lesions declined from 27% to 6%. The sensitivity of FNAC increased from 67% to 90% and the accuracy from 60% to 81%. The malignant/benign ratio of surgery rose from 1.4 in the first screening round to 2.8 in the third. One-step surgery as definitive treatment was performed in 67% of malignant instances. DISCUSSION: The preoperative diagnostic assessment improved during the evaluation period. The triple test was used more often over time, the validity of FNAC and the malignant/benign ratio of surgery increased.
Prostate cancer is not increased in men with vasectomy in denmark.
PURPOSE: The risk of prostate cancer after vasectomy was studied using population based register data from Denmark. MATERIALS AND METHODS: Men hospitalized for vasectomy in Denmark from 1977 to 1989 were followed for death, emigration and incident cancer by administrative registers. The observed number of patients with cancer in the cohort was divided by the number expected based on the cancer incidence rate for all Danish men, providing a standardized incidence ratio. RESULTS: A total of 46 cohort patients were diagnosed with prostate cancer, while 46.93 were expected (standardized incidence ratio 0.98, 95% confidence interval 0.7 to 1.3). Time since vasectomy or age at vasectomy showed no trend. CONCLUSIONS: This population based Danish cohort study indicated no increase in the risk of prostate cancer in men hospitalized for vasectomy. The study was free of reporting bias since all data were collected from administrative registers. The cohort was not comprehensive but it most likely represented an unbiased sample of Danish men who underwent vasectomy. The study strongly adds to the evidence that there is no excess prostate cancer risk after vasectomy is done for sterilization.
Overdiagnosis, sojourn time, and sensitivity in the Copenhagen mammography screening program.
The goal of this research was to estimate the overdiagnosis at the first and second screens of the mammography screening program in Copenhagen, Denmark. This study involves a mammography service screening program in Copenhagen, Denmark, with 35,123 women screened at least once. We fit multistate models to the screening data, including preclinical incidence of progressive cancers and nonprogressive (i.e., overdiagnosed) cancers. We estimated mean sojourn time as 2.7 years (95% confidence interval [CI] 2.2-3.1) and screening test sensitivity as 100% (95% CI 99.8-100). Overdiagnosis was estimated to be 7.8% (95% CI 0.3-26.5) at the first screen and 0.5% (95% CI 0.02-2.1) at the second screen. This corresponds to 4.8% of all cancers diagnosed among participants during the first two invitation rounds and following intervals. A modest overdiagnosis was estimated for the Copenhagen screening program, deriving almost exclusively from the first screen. The CIs were very broad, however, and estimates from larger datasets are warranted.