Biomedical subjects

Eric T Stoopler

Publications and source records attributed to Eric T Stoopler.

At least 19 recordsLinked to original sources

PubMed2006

Bullous amyloidosis of the oral cavity: a rare clinical presentation and review.

Bullous amyloidosis (BA) is a rare cutaneous manifestation primarily of systemic amyloidosis, a disease in which abnormal proteinaceous material is formed and deposited in response to inflammatory conditions and plasma cell dyscrasias. Hemorrhagic bullae indicative of BA are usually associated with purpura and may be the initial clinical signs of systemic amyloidosis or monoclonal gammopathies, such as multiple myeloma and Waldenstrom's macroglobulinemia. Bullous amyloidosis of the oral cavity is highly uncommon and can mimic other vesiculobullous lesions of the oral mucosa. This article highlights an unusual case of oral BA and reviews important aspects of the disease.

Amyloidosis↗

PubMed2005

Oral herpetic infections (HSV 1-8).

Oral herpes virus infections are commonly seen by the dental practitioner. Saliva is a reservoir for the herpes virus, and a variety of infections, both localized and systemic, may be induced by the virus. Patients who are immunocompromised may be at risk for serious and potentially life-threatening complications of herpes virus infections. This article highlights the basic virology and clinical manifestations of herpetic infections and the differential diagnosis and management of oral herpes virus infections.

Cytomegalovirus Infections↗

PubMed2005

Pioneer of oral medicine: Lester W. Burket, D.D.S., M.D.

Lester William Burket (1907-1991) was a man of intellect, integrity, and vision. He was a pioneer in the field of oral medicine and is considered by many to be the father of this discipline. He was one of the first educators to promote the concept of integration of medicine into dental education and clinical practice. His belief of oral health mirroring systemic health was innovative for it's time, and has now become standard philosophy in both the medical and dental professions. Dr. Burket's legacy has enhanced the quality of life for millions of patients, improved dental education, and reinforced the idea of dental professionals as primary health care providers.

History of Dentistry↗

PubMed2005

A study of benzocaine gel dosing for toothache.

OBJECTIVE: This pilot study evaluated subject compliance with a proposed OTC label with improved dosing directions for self-application of a 20% benzocaine gel for toothache pain, and assessed the methodology for evaluating efficacy in a future pivotal study of benzocaine gel. It was hypothesized that > or = 75% of subjects would apply < or = 400 mg of product (80 mg benzocaine). Exploratory analyses of efficacy were also performed. METHODOLOGY: Thirty patients with spontaneous pain of moderate or severe intensity from a single tooth due to caries, a lost restoration, or a fracture entered this randomized, parallel group, double-blind study. Before self-applying 20% benzocaine gel or placebo, patients read a label containing new dosing directions, including a picture of how much product to apply to their tooth and the surrounding gingival tissues. The amount applied was determined by weighing the tube before and after dosing. Following dosing, pain intensity and relief were recorded every five minutes through 30 minutes, then every ten minutes through 120 minutes. Responders were defined as those subjects who experienced at least a one-unit reduction in pain intensity from baseline at two consecutive time points within the first 20 minutes. Onset of meaningful relief was recorded using a stopwatch. The percentage of responders was compared using the Mantel-Haenszel test. ANOVA was employed to test for differences in Pain Relief Combined with Pain Intensity Difference (PRID), and the areas under the curve at 30, 60, 90, and 120 minutes for this measure (SPRID). Median onset and duration times were compared using the Cox proportional hazards model. Adverse events were recorded if and when they occurred. RESULTS: It was found that 86.7% of the subjects (26/30) applied < or = 375 mg of product (mean +/- SD = 327.7 +/- 276.8 mg). The benzocaine group had a significantly higher (p = 0.022) responder rate (86.7%) than the placebo group (46.7%). Significant differences in favor of the benzocaine group were also recorded for PRID at 10, 15, and 30 minutes (p < 0.05) and SPRID-30 (p = 0.037). Median onset and duration times were 8.3 minutes and > 115 minutes for the benzocaine group, >120 minutes and 5 minutes for the placebo group. There were no adverse events recorded in the study. CONCLUSION: The improved dosing directions resulted in a high percentage of subjects self-applying an appropriate amount of benzocaine gel or matching placebo. The label and study methodology appear suitable for a pivotal dose-response study in subjects with toothache pain. While the current study was not statistically powered to make firm efficacy conclusions, 20% benzocaine gel appeared more efficacious than placebo, providing a rapid onset of pain relief and a relatively long duration of action.

Adolescent↗

PubMed2003

Update on herpesvirus infections.

Herpesviruses are responsible for many illnesses that affect the oral and maxillofacial region. The most common of these are primary or recurrent HSV infection, but knowledge of the manifestations of the eight herpesviruses that cause infections in humans will provide clinicians with a better understanding and basis for diagnosing and managing patients with these diseases. Immunocompromised patients are at greater risk for serious illness: therefore, clinicians treating transplant patients, patients receiving cancer chemotherapy, or HIV-infected individuals should be aware of the various clinical manifestations of infection with herpesviruses.

Dental Care for Chronically Ill↗

PubMed2003

Amyloid deposition in the oral cavity: a retrospective study and review of the literature.

OBJECTIVE: A retrospective study was conducted to investigate the anatomic location and characteristics of amyloid deposition in the oral cavity. STUDY DESIGN: Seventeen biopsy specimens that were conclusive for a diagnosis of amyloidosis were assessed in terms of their anatomic location and histopathologic characteristics. RESULTS: Biopsy specimens were received from 13 patients-9 females and 4 males. Six specimens were taken from the buccal mucosa, 4 from the tongue, 3 from the palate, 2 from the gingiva, and 2 from the floor of the mouth. Fifteen of 17 specimens (88%) had amyloid deposition in the subepithelial connective tissue in all locations. CONCLUSION: On the basis of our pilot data, a previously overlooked intraoral anatomic location, the buccal mucosa, may prove to be of higher diagnostic value than others previously reported in terms of obtaining a diagnosis of amyloidosis. In addition, the manner in which tissue biopsies are conducted for amyloid detection may be altered to create less morbidity.

Adipose Tissue↗

PubMed2003

Cheilitis glandularis: an unusual histopathologic presentation.

Cheilitis glandularis (CG) is an uncommon disease that usually affects the lower lip of adults. It is characterized by enlargement and eversion of the lip in association with excretory duct dilatation. The presence of minor salivary gland hyperplasia is controversial. Three types of CG have been described in the literature; the classification is based on the common clinical and histopathologic findings (ie, simple, superficial, and deep). This report is of an unusual case of CG simplex for which the initial histopathologic diagnosis was papillary cystadenoma, a neoplastic process. The lesion was completely excised, and final microscopic review of a larger specimen revealed chronic sclerosing sialadenitis, dilated salivary secretory ducts with oncocytic change and periductal inflammation, and foci of adenomatous hyperplasia consisting of enlarged ducts exhibiting squamous epithelial metaplasia and hyperplasia with papillary architecture. The latter proliferative pattern is an unusual finding in what is otherwise clinically diagnosed as CG.

Cheilitis↗

PubMed2003

Recurrent aphthous stomatitis. Update for the general practitioner.

Patients presenting with oral mucosal disease can be challenging to diagnose and manage. There are several disorders that can present with similar clinical signs and symptoms, and knowledge of each disease will guide the clinician toward proper management. This article highlights recurrent aphthous stomatitis, a common ulcerative condition encountered in clinical practice. We review the etiology, clinical symptomatology, and topical/systemic therapies that are unique to this disorder and that will help clinicians diagnose and manage this condition.

Administration, Topical↗

PubMed2003

Betel quid-induced oral lichen planus: a case report.

The social use of betel nut is relatively common in certain geographic areas, especially India and Southeast Asia. The term betel nut does not truly describe the product that is chewed; rather, the term quid is more accurate because it refers to a substance or mixture of substances, including the areca nut, that are chewed and remain in contact with the mucosa. Betel quid is a type of quid that contains betel leaf. Chewer's mucosa and oral submucous fibrosis are clinical entities that have been associated with betel quid use. We report a case of oral lichen planus induced by betel quid use in a 79-year-old Cambodian woman.

Aged↗

PubMed2003

Extensive pneumatization of the temporal bone and articular eminence: an incidental finding in a patient with facial pain. Case report and review of literature.

A 53-year-old Caucasian female presented to the Oral Medicine Department at the hospital of the University of Pennsylvania for consultation regarding facial pain. A panoramic radiograph revealed multilocular radiolucencies in the right articular eminence. A CT scan was then performed, and the radiolucencies were determined to be pneumatization of the articular eminence.

Air↗

PubMed2003

Desquamative gingivitis: early presenting symptom of mucocutaneous disease.

Desquamation of the gingiva is a sign that may be encountered in clinical practice. Various diseases can affect the gingival tissues. Mild desquamation that is localized may be associated with mechanical irritation or induced by trauma. Moderate to severe generalized desquamation associated with ulceration and erythema may be indicative of a more serious systemic condition. Although often overlooked, mucocutaneous diseases frequently present with gingival desquamation as an early presenting symptom. The most common mucocutaneous diseases that affect the oral cavity are lichen planus, pemphigus, and mucous membrane pemphigoid. This article reviews the etiology, signs and symptoms, and therapies for these disorders. Increased knowledge of mucocutaneous diseases can help the clinician recognize these disorders and enable the patient to receive appropriate therapy.

Anti-Inflammatory Agents, Non-Steroidal↗

PubMed2003

Mucous membrane pemphigoid. Update for the general practitioner.

A common patient complaint that may be encountered in practice is desquamation of oral tissue. Moderate-to-severe, generalized oral desquamation associated with ulceration and erythema could be associated with systemic mucocutaneous disease. Systemic mucocutaneous diseases that affect the oral cavity include lichen planus, pemphigus and mucous membrane pemphigoid. This article will review the etiology, clinical presentation and management of mucous membrane pemphigoid.

Diagnosis, Differential↗

PubMedDate not supplied

Granulocytic sarcoma: an atypical presentation in the oral cavity.

Acute myelogenous leukemia (AML) is a hematologic disorder that is characterized by an abnormal proliferation of immature myeloid cells. Granulocytic sarcomas are clusters of leukemic myeloid cells that may develop as a result of AML. Oral manifestations of AML are common and often involve enlargements of the gingiva and/or mucosal tissue from direct leukemia cell infiltration. We describe the case history of a 50-year-old man who had an ulcerative lesion of the oral mucosa that was determined to be a granulocytic sarcoma of AML-MO subtype. The combination of both the subtype and clinical presentation of the leukemia makes this presentation unusual, and to the best of our knowledge, of a type that has not been previously reported in the literature.

Diagnosis, Differential↗

PubMedDate not supplied

Oral lichen planus. Update for the general practitioner.

There are a variety of dermatologic disorders that commonly present in the oral cavity. Among these is lichen planus which may affect the oral mucous membranes. Dentists need to be familiar with the clinical presentations of this disease. This article will review the common signs and symptoms of oral lichen planus, and will discuss the tools and criteria used to diagnose this disorder. We will also described the modalities available to clinicians to treat this disease.

Administration, Topical↗

PubMedDate not supplied

Pemphigus: update for the general practitioner.

Pemphigus is a dermatologic disease that can affect both the skin and mucous membranes. Pemphigus affects the oral cavity; the most common form of the disease that is observed clinically is pemphigus vulgaris. Oral lesions may precede skin lesions; therefore, it is imperative that clinicians are aware of the clinical signs and symptoms of this disorder. This article will review the etiology, symptomatology, diagnostic tools, and treatments available to diagnose and manage this disease.

Glucocorticoids↗

PubMedDate not supplied

Seizure disorders: update of medical and dental considerations.

Seizure disorders and epilepsy represent neurologic conditions that commonly are seen among patients requiring dental treatment. When dentists possess a working knowledge of seizures, in addition to an understanding of updated therapies for seizure management and oral complications associated with pharmacological therapy, they are able to treat patients with these disorders more effectively. Neurologic consultations and selecting an appropriate venue for treatment may need to be addressed prior to treatment, depending on the level of seizure control. Laboratory tests designed to evaluate medication levels, leukocyte counts, and clotting ability also may be required. Frequent recall visits may be necessary for seizure disorder patients who display adverse oral complications from medication, such as gingival hypertrophy, xerostomia, and oral yeast infections.

Anticonvulsants↗

PubMedDate not supplied

Burning mouth syndrome: a guide for the general practitioner.

A commonly misdiagnosed condition, burning mouth syndrome (BMS) is characterized by burning sensations of the oral cavity in the absence of physical abnormalities of the oral mucosa. BMS affects middle-aged women predominantly. This condition has a multifactorial etiology, although several conditions have been associated with BMS, including depression/anxiety, hematinic deficiencies (iron, folate, and vitamin B complex), oral habits such as tongue thrusting and bruxism, and idiopathic BMS. Multiple approaches to treatment have been described in the literature, although few controlled clinical trials have been designed to determine their efficacy. This article examines BMS, its related factors, and treatment options available to the general dentist.

Burning Mouth Syndrome↗

PubMedDate not supplied

Temporomandibular disorders and fibromyalgia: comorbid conditions?

Temporomandibular disorders (TMDs) and fibromyalgia (FM) are two clinical conditions prevalent in today's society. Many individuals suffer from chronic pain in various muscle groups, including the muscles of mastication. Previously, TMDs and FM were thought to be separate, unrelated clinical entities. New research has shown a possible link between the two conditions; this article sheds light on possible correlations between them.

Fibromyalgia↗