Biomedical subjects
Publications and source records attributed to F A Bahmer.
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According to Cavalieri, the volume of any body-irrespective of its shape-can easily be estimated on the basis of the area of slabs of known thickness. We made use of this old principle in order to determine the correlation between the volume of skin tumors and their maximal vertical thickness. Investigations of a total of 30 benign and malignant tumors of the skin of various shapes showed a correlation coefficient of r = 0.77. Therefore, the widely used determination of the vertical thickness of malignant melanomas can be regarded as a good estimator of the tumor volume and seems to be appropriate for histological tumor staging. Together with high frequency ultrasound, Cavalieri's method allows a simple and rapid pretherapeutical in-vivo determination of the tumor volume. However, only prospective studies can reveal whether the determination of the tumor volume is of superior prognostic significance to the established techniques.
On the basis of the latest findings, we present the main aspects of cutaneous leishmaniasis with regard to epidemiology, vector, clinical features, histopathology, diagnosis, differential diagnosis, immunology, and therapy.
We describe the hardware and software components of the computer system used for the storage and handling of data in our dermatopathological laboratory. It consists of a Siemens MX2 microcomputer operated by the Unix-based Sinix operating system and the Informix relational data base system. On the basis of a dermatopathology thesaurus with more than 200 different diagnoses, the system allows quick access to diagnostic and patient data and supplies rapid seaching and sorting facilities. In addition, the system can optimize the productivity of a laboratory like that.
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There are a number of local factors which might contribute to the induction and persistence of contact allergies in patients with chronic venous insufficiency of the lower leg and their sequelae such as stasis dermatitis and leg ulcers. Thus, the acanthotic epidermis might have a certain "reservoir function" for potential contact allergens. Furthermore, the density of epidermal Langerhans' cells is increased in areas of stasis dermatitis, and the dermis contains a high number of cells bearing HLA-DR antigens, which might act as antigen-presenting cells.
We report on 52 dermatologic patients suffering from chronic alcoholism. The skin changes observed mainly consisted of erythrosis interfollicularis colli, icterus of the sclerae, teleangiectatic reddening of the face, and diminished secondary hair. In 29 out of 44 sera investigated, we found elevation of the gamma-glutamyl transferase. In 17 patients, serum samples were analyzed for zinc. In 16 cases, the zinc levels were slightly decreased but still within the normal range, i.e. below 100 micrograms/dl. The biotin levels in the 48 serum samples examined varied very much. In 6 patients, however, we found definitely lowered values. Our results support the view that routine investigation of serum zinc and biotin levels might be valuable in patients suffering from chronic alcoholism associated with cutaneous changes. If lowered values are found, a substitution therapy might be of benefit at least in some patients.
This report is on a 33-year-old female patient with Crohn's disease of the intestine and nonhealing leg ulcers which histologically showed the typical noncaseating epithelioid granulomas of sarcoid structure defining the so-called 'metastatic Crohn's disease'. Furthermore, as a very rare pattern, extensive necrobiotic areas surrounded by sarcoid granulomas were observed.
The density of Langerhans' cells (LC) stained with ATPase was determined in epidermal sheet preparations in skin specimens from patients with stasis dermatitis of the lower leg. Their density was highest in areas adjacent to manifest stasis dermatitis areas. Clinically diseased skin contained less LC than the adjacent areas, but still more than skin from control patients without venous insufficiency. The increased number of ATPase positive cells within and around stasis dermatitis skin might contribute to the high number of contact allergies observed in this patient group because of the antigen presenting capacity of these cells.
The rise in the incidence of dapsone-resistant leprosy requires new therapeutic approaches. Based on the recommendations of the WHO and the experiences from many countries where leprosy is endemic, a standardized treatment regimen is presented. It is based on the combination of three chemotherapeutically active substances.
Two methods are described for the assessment of lymphocyte migration areas. One, based on the principle of point counting, allows precise area determination by the aid of a small, transparent grid. The other, similar method with appropriately spaced circles might be used for the classification of such migration areas whose shape approach a circle.
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Serological studies were performed in 3 patients with typical contact urticaria to latex surgical gloves. Specific IgE antibodies to natural latex as well as to vulcanized glove material have been detected by radioimmunoassay. Contact urticaria to latex is considered to be of the immunologic type.
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Nevus lipomatosus of Hoffmann-Zurhelle is a rare condition characterized by ectopic accumulation of adipose tissue which is located almost always on the lower trunk. We present a typical case and give a detailed survey on the pertinent literature.
We report on a 69-year-old woman suffering from an erosive pustular and crusted lesion of the scalp having persisted over years. There could not be found any external cause, and a large number of different physical and medicamental therapies failed. Prompt healing was achieved, however, after a low serum zinc level was corrected by a zinc preparation administered orally.-The dermatosis described closely resembles the so-called "erosive pustular dermatosis of the scalp". A search of the earlier dermatological literature supported our view that this is not a new disease, but rather a variant of pyoderma vegetans, a disease showing extremely variable clinical and histopathological features.
A case of a severe, widespread bullous dermatosis clinically resembling pemphigus foliaceus occurred during treatment with penicillamine hydrochloride in a patient with rheumatoid arthritis. Histologically, the disease showed changes compatible with pemphigus vulgaris as well as with a bullous drug eruption. Treatment by plasmapheresis proved to be effective in controlling the disease.