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F A Kolodub

Publications and source records attributed to F A Kolodub.

33 records · Page 2Linked to original sources
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[Effect of ATP and glutaminic acid on carbohydrate-energy and nitrogen metabolism in the rat brain and liver under the effect of pulsed electromagnetic field].

Oxidative phosphorylation, content of lactate, creatine phosphate, ammonia and glutamine were studied as affected by ATP and glutaminic acid in the brain and liver of rat subjected to the action of the pulsed electromagnetic field of 7 kHz frequency (72 kA/m, 15 seances). ATP (1 mg per 100 g of weight) was found to have a normalizing effect on the processes of nitrogen metabolism in the rat brain, ATP increasing the intenstiy of the oxidative phosphorylation in the tissues of intact rats, has no analogous influence on the irradiated animals. With administration of glutaminic acid (5 mg per 100 g of weight) the processes of oxidative phosphorylation and nitrogen metabolism, disturbed under the effect of the pulsed electromagnetic field are normalized.

Adenosine Triphosphate↗
PubMedDate not supplied

[Oxidative and free-radical processes in the mechanism of toxic effect of anti-diabetic drugs dicarboxylic acids derivatives].

Dynamics of changes in the processes of the lipids free-radical peroxide oxidation (LPO), state of the monooxygenase system (MOS) and system of anti-oxidant protection (SAOP) in the liver and blood of rats under multiple peroral and inhalatory expositions of anti-diabetic drugs--dicarboxylic acids derivatives: phensuccinalum (PhS) and diacamph (Dc) in toxic and sub-toxic doses is studied. It has been found that one of the key biochemical mechanisms which determines the early signs of the toxic damage in the cells and organism under the effect of certain doses/concentrations of PhS (500 and 100 mg/kg, 20.2 mg/m3) and Dc (1000 mg/kg) consists in intensification of the free-radical processes, including, in particular, LPO combined with activation of MOGS and inhibition of SAOP in microsomal fraction of the liver. The high significance of changes of researched parameters for an assessment or forecasting of toxicity of dicarboxylic acids derivates is shown. Unlike the liver, the PhS and Dc impact on the blood caused changes of compensatory-adaptive nature in the LPO and SAOP systems.

Animals↗
PubMedDate not supplied

[Peculiarities of carbohydrate energy and nitrogen metabolism in rat brain affected by magnetic fields of commercial frequency].

Carbohydrate oxidation, the coupling of oxidation with phosphorylation and the level of nucleic acids in the brain tissue were studied as affected by variable magnetic fields of commercial frequency (50 Hz) depending on intensity and regime of generation. A repeated effect (15-seances) of the 32 kA/m continuous magnetic field decreases the content of glycogen, creatine phosphate, intensity of oxygen uptake and etherification of inorganic phosphate, glutamine and increases the DNA content. The 7.5 kA/m continuous magnetic field has no effect on the studied metabolic indices in the brain whereas the interrupted field (1s impulse duration, 2s interimpulse interval) of the same intensity and exposition lowers the amount of glycogen, glucose, creatine phosphate, the RNA and DNA exposition lowers the amount of glycogen, glucose, creatine phosphate, the RNA and DNA levels, activates the oxidation processes, intensifies their coupling with phosphorylation.

Animals↗