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F Algaba

Publications and source records attributed to F Algaba.

At least 37 records · Page 2Linked to original sources
PubMed1999

Intravesical bacille Calmette-Guérin in the treatment of carcinoma in situ or high-grade superficial bladder carcinoma after radiotherapy for bladder carcinoma.

OBJECTIVE: To evaluate the effectiveness and tolerance of endovesical bacille Calmette-Guérin (BCG) after pelvic radiation therapy for bladder cancer in patients with recurrence as carcinoma in situ (CIS) and/or high-grade superficial bladder cancer. PATIENTS AND METHODS: In a prospective study, 13 patients were treated with weekly instillations of 81 mg BCG Connaught for 6 weeks. for CIS and/or high-grade superficial bladder carcinoma. All had been treated previously with radical radiation therapy for bladder carcinoma. RESULTS: Five patients had no recurrences and six patients retained their bladders, within a median follow-up of 74.5 months. Five patients progressed; two underwent radical surgery and are alive after 75 months of follow-up, and three died from the disease (two were high-risk surgical patients and one had metastatic disease). Another two patients died from intercurrent disease without bladder cancer. Eight patients were alive at a mean (SD range) follow-up of 85 (12, 65-97) months. CONCLUSION: Intravesical BCG is useful for controlling CIS and/or high-grade superficial bladder carcinoma in irradiated bladders and has an acceptable local tolerance: more than a third of patients were free of disease and preserved their bladders. This proportion is acceptable in patients currently scheduled for cystectomy.

Adjuvants, Immunologic↗
PubMed1999

Evolution of isolated high-grade prostate intraepithelial neoplasia in a Mediterranean patient population.

The discovery of high-grade prostatic intraepithelial neoplasia (HGPIN) in prostatic needle biopsies is of clinical importance. Previous studies have shown prostate cancer to develop in 27-100% (average 55%) of the cases after HGPIN was diagnosed. Our preliminary findings in a Mediterranean population (Barcelona, Spain) revealed a prevalence of HGPIN of 4.4%, and an incidence of prostate cancer of 28.7% in cases in whom isolated HGPIN was identified at the first biopsy. The majority (64%) of these cases were diagnosed at the first biopsy after HGPIN diagnosis, and 52% within the first year. HGPIN persisted in 46.6% of the cases. The total mean serum prostate-specific antigen (PSA) was 9.9 +/- 6.6 ng/ml in the prostate cancer cases, compared with 8.8 +/- 7.5 in the cases without cancer. The low incidence of isolated HGPIN and subsequent cancer occurrence may be due to local factors or insufficient follow-up.

Biomarkers, Tumor↗
PubMed1999

[Cystitis glandularis].

OBJECTIVE: To discuss the presenting features, diagnosis and treatment of cystitis glandularis. METHODS/RESULTS: 15 patients consulted for voiding syndrome, hematuria, hypogastric pain and chronic cystitis. Ten patients were evaluated by IVP which showed bilateral ectasia in 6, an abnormal renal pelvis in one and the remaining three patients were normal. Eight patients were evaluated by cystography which showed a reduced bladder capacity in three, bilateral reflux in three and an abnormal bladder wall in two patients. Urinalysis was performed in all 15 patients; only 5 patients showed a positive culture. These 5 patients had recurrent episodes and underwent cystoscopy and biopsy and/or TUR. Sixty percent was associated with a foreign body, lithiasis, bladder exstrophy, pelvic lipomatosis and BPH. Diagnosis was based on the histological findings; 40% had a bladder tumor. CONCLUSIONS: Patients with cystitis glandularis present with voiding syndrome and chronic cystitis. The IVP, US and cystographic findings are usually normal or may indicate a tumor. Diagnosis is based on the histological findings.

Cystitis↗
PubMed1998

Primary bladder carcinoma in situ: assessment of early BCG response as a prognostic factor.

OBJECTIVES: To evaluate the prognosis of primary bladder carcinoma in situ (CIS) according to the response to bacillus Calmette-Guerin (BCG). PATIENTS AND METHODS: Twenty-six cases of primary CIS were treated with BCG. Mean, median and minimum follow-up periods were 47, 56 and 24 months. At 6 months, the patients were evaluated endoscopically and the response was classified as complete, partial or failure. RESULTS: Twenty-one patients (80.8%) showed complete response to BCG, 3 did so after a second course; 28.5% relapsed or progressed at a mean of 44 months. Five patients (19.2%) did not respond initially and all progressed in a period of 6 months. Early response to BCG was the only significant prognostic factor (p < 0.005). CONCLUSIONS: A high- and a low-risk group of bladder CIS can be differentiated according to the response to BCG. CIS of the bladder has a poor prognosis, and the number of patients who developed progressive disease is significantly higher among the nonresponders.

Administration, Intravesical↗
PubMed1997

Growing teratoma syndrome: experience of a single institution.

OBJECTIVE: To analyze the clinical outcome of patients diagnosed with growing teratoma syndrome (GTS) at a single center during a long follow-up. PATIENTS AND METHODS: Eleven patients with GTS are reported. GTS lesions were located in the metastatic sites involved at disease presentation. Involved sites were: retroperitoneum in 9 patients; lung in 3; supraclavicular lymph nodes in 2, and inguinal lymph nodes in 1. Surgical resection of the masses was the treatment of choice. RESULTS: Twenty-four surgical procedures were performed: 4 thoracotomies; 2 supraclavicular; 1 inguinal, and 17 retroperitoneal node resections. Three patients have not relapsed since surgery of the masses, at 37+, 110+ and 118+ months. Eight patients have relapsed, 6 with mature teratoma and 2 (22%) with cancer. To date, all the patients are alive, 6 of them without disease and 5 with teratoma after resection of the masses. CONCLUSIONS: GTS is an infrequent entity. Involved sites are only at locations previously affected by the disease. The treatment of choice is surgical resection but recurrence is common. Efforts should be done to complete resection of the masses.

Adolescent↗
PubMed1997

[Squamous cell carcinoma of the penis: treatment protocol according to our 14 years of experience].

OBJECTIVE: The management of lymph nodes and the determination of prognostic factors are matters of controversy in the treatment of squamous cell carcinoma of the penis. We attempted to establish an approach based on the different types of lymphadenectomies and biopsies we have performed and to evaluate local stage and grade of cellular differentiation as prognostic factors. METHODS: 81 cases treated at our institution between 1980 and 1994 were reviewed. The results of the different lymphadenectomies and biopsies performed were analyzed. Tumors were staged according to the Jackson and TNM classifications; in 62 cases the pathological samples were reexamined by the same pathologist to determine the grade of cellular differentiation according to the Broders classification. A p value of < 0.05 was considered significant. RESULTS: We did not obtain reliable results with the biopsies done and variable results in the lymphadenectomies performed. The grade of cellular differentiation and local stage were both statistically significant with respect to the presence of positive lymph nodes. We found statistically significant differences for survival according to the stage of the positive lymph nodes. CONCLUSION: We have established three approaches in management of squamous cell carcinoma of the penis according to the local stage and grade of cellular differentiation.

Adult↗
PubMed1997

Grade, local stage and growth pattern as prognostic factors in carcinoma of the penis.

OBJECTIVES: To assess the management of adenopathies and the determination of prognostic factors in the treatment of squamous carcinoma of the penis. MATERIALS AND METHODS: We reviewed 81 cases treated at our Institution between 1980 and 1994. In 62 cases, we review the pathologic samples according to the growth patterns proposed by Cubilla et al. RESULTS: We find that both the grade of cellular differentiation and the local stage of the tumor are statistically significant with respect to the presence of positive adenopathies. We obtain results similar to Cubilla's work and different survival rates for the patterns of tumor growth. CONCLUSIONS: On the basis of our results, we propose 3 differentiated follow-up and treatment groups. We suggest that the new growth pattern classification is useful as prognostic factor in carcinoma of the penis. We corroborate that prophylactic lymphadenectomy is indicated in tumors of vertical growth, while a conservative management should be considered in tumors of verrucous growth.

Adult↗
PubMed1996

Mortality in testicular cancer: 10 years' experience at a single centre.

The aim of the present study was to investigate the causes of death in patients with germ cell testicular tumours (GCTTs), especially those due to persistent or recurrent tumours, and to determine potentially avoidable deaths. Among 299 patients with GCTTs there were 27 (9%) deaths: 21 (78%) had non-seminomatous GCTTs and 6 (22%) had seminomatous GCTTs. Sixteen deaths (59%) were due to progressive disease, 6 (22%) were treatment-related, 4 (15%) were due to incidental causes, and 1 was a sudden, unexplained death. The analysis of the data led us to the conclusion that some deaths are still potentially avoidable.

Adolescent↗
PubMed1996

Diagnostic limits in precursor lesions of prostatic cancer.

OBJECTIVE: Among prostatic lesions with atypical features, atypical adenomatous hyperplasia (AAH; microglandular proliferation with bland nuclei), and prostatic intraepithelial neoplasia (PIN; cellular atypia in preexisting large ducts and acini) are considered precursors of prostatic cancer, but these lesions are a continuum from the normal prostate to prostatic cancer. The objective of the paper is to bring attention to the pitfalls in the diagnosis of both lesions. MATERIAL AND METHODS: To describe the diagnostic limits in AAH and PIN, we used the literature information and our 76 cases of AAH and 169 patients with PIN at prostatic core biopsy. CONCLUSIONS: In the majority of cases, AAH appears in the transition zone and it is necessary to be very strict in the diagnosis in order to avoid confusion with microglandular BPH. One of the controversies is the biologic significance of prominent nucleoli in the AAH. Although the association of AAH with cancer is relatively scant, we have a higher incidence of cancer in cases with AAH than in classic BPH and we recommend complete study of the surgical specimen. Low-grade PIN does not need to be reported, but high-grade PIN should be and close follow-up is recommended if we find an isolated high-grade PIN. Because the clinical implications of high-grade PIN are so important, pathologists must be sure of the diagnosis avoiding interpretation in inflammatory areas. The high-molecular-weight cytokeratins may be useful in some cases, when the diagnosis of adenocarcinoma vs. high-grade PIN is seriously considered.

Adenocarcinoma↗
PubMed1996

[Treatment of prostate benign hyperplasia (BPH) with visually controlled laser, assessment at 2 years, and anatomopathologic findings].

The endoscopically-guided lateral discharge laser (VLAP) has been considered an alternative in the management of benign prostate hyperplasia (BPH). The purpose of this paper is to describe the technique, results obtained in 20 treated patients, and pathoanatomical findings in those later treated with prostate transurethral resection. Four patients were carriers of an indwelling catheter, while IPSS/QL mean values in the other 16 patients were 23/4. Mean maximum flow was 7.01 mL/s. Assessment after one and two years shows a fall of mean IPSS/QL to 5/1 and mean maximum flow to 15.2 mL/s and 21 mL/s, respectively, but the difference is not significant. This paper also describes the morbidity affecting 65% patients, which is comparable to the retreatment rate (15%) obtained in other series published. The results are similar to those described in the literature although, in our view, the high rate of complications undermines this choice as an alternative in BPH management.

Aged↗
PubMed1995

Working standards in prostatic intraepithelial neoplasia and atypical adenomatous hyperplasia.

All participants agreed with the use of the terms low and high grade PIN, without treatment in the case of an isolated PIN lesion. The term, definitions and biology of atypical adenomatous hyperplasia (AAH) was discussed without reaching a consent among American and European participants. As a compromise, the designation of AAH-Adenosis was accepted as a working formulation that needs further research.

Humans↗