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Biomedical subjects

F Beatrice

Publications and source records attributed to F Beatrice.

At least 19 recordsLinked to original sources
PubMed2003

Update and perspectives on non-surgical treatment of salivary gland malignancies.

Surgery is the treatment of choice for major and minor salivary gland malignancies. Herein, the role of radiation and medical treatment in the multidisciplinary management of salivary gland tumours is discussed. Neutron irradiation and hyperfractionated external beam mega voltage irradiation improve local control. Combination of three dimensional conformal radiotherapy and intensive-modulated radiation therapy provide better local tumour delineation, better field design to encompass the tumour allowing dose escalation to target while sparing the surrounding normal tissue. Cisplatin-based chemotherapy provides a response rate > or = 45%, in a palliative setting. Concomitant chemo-radiotherapy could improve local control. Recent studies evaluated the expression of molecular targets in salivary gland carcinomas (c-kit = 53-90%, EGFR = 25-85%, c-erb-B2 = 11-58%, p53 = 11-67%, H ras = 18%); these targets are very important since new targeted drugs are now available. Anti-androgen therapy might have a role in the management of patients with ductal carcinoma. These new targeted drugs could be integrated with chemotherapy and radiotherapy in the treatment of locally advanced/metastatic salivary gland malignancies.

Adult↗
PubMed2001

[Non-auditory effects of environmental noise: a study of metallurgical and mechanical workers].

The present work was performed to check the non-auditory effects of environmental noise on a homogeneous worker population. The study was performed on 200 workers (factory and office workers) in a metallurgical and mechanical company: each individual underwent thorough clinical-audiometric study and filled out a multiple-choice psycho-social-attitude questionnaire. Statistical analysis of the results obtained showed a significantly higher number of non-auditory effects in subjects exposed to noise vs. those not exposed. For all workers studied, this incidence increased proportionally with age and job seniority. Moreover, it was demonstrated that there is no direct correlation between non-auditory effects and chronic traumatic hearing loss. The limited number of cases examined, however, suggests a multi-center study in order to provide better clinical-scientific and statistical-epidemiological study of this complex question involving on-the-job noise.

Adult↗
PubMed1996

[Laryngeal cancer and angiogenesis].

Angiogenesis is required for the growth of solid tumors which, in avascular condition, are limited to 2-3 mm3 volume. The switch to the angiogenic phenotype allows new vessels to converge upon the tumor, growth to proceed at an exponential rate and metastasis diffusion. The evaluation of tumoral angiogenesis has been proposed to be an independent prognostic marker of behaviour of some solid tumors: it has been demonstrated that, in some types of carcinoma (breast, prostate, lung, etc...), an intense vascular proliferation correlates with the aggressiveness of the disease. However in malignant melanomas and colorectal carcinomas, there are conflicting results on the correlation between angiogenesis and the progression of the cancer. There are also conflicting data on the role of microvessels count (MC) in the management of head and neck cancer. Despite a large number of studies, at the present, there are not biological or molecular markers available to predict consistently the outcome of the patients with laryngeal squamous cell carcinoma (LSCC). In fact the prognosis of this tumor has been mainly based, up to now, on a number of clinico-pathological parameters, especially localization, tumor extent and nodal involvement. The aim of this study has been to compare MC inside LSCC with disease free survival, grading, pT, pN and pathological stage. We investigated the relevance of the number of microvessels in the peritumoral stroma of 68 LSCC (only Caucasian males, age 35-70 years), classified according to UICC/1987 randomly selected (33 classified in clinical stage I e II and 35 in clinical stage III-IV). All patients have been surgically treated and pN + cases have been also submitted to radiotherapy. The follow-up was 60-84 months. The vascular density was assessed according to Horak et Al. with an immunohistochemical method using JC70 monoclonal antibody (CD31; Dako, Astrup, Denmark). Univariate analysis showed that MC, pT, pN, Pathological Stage and grading were correlated with the disease-free survival. A MC < 120/mm2 was predictive for a high survival index; in contrast a MC > 150 mm2 were associated with relapse. Furthermore, multivariate analysis demonstrated that MC was the only independent predictor for the disease free survival. Our findings demonstrate that in LSCC, MC is the first measurable biological parameter which is significant for evaluating the disease free-survival. Therefore, MC in LSCC is crucial in the prognosis and in the choice of a more aggressive management of the disease, including the possible treatment with antiangiogenic compound.

Adult↗
PubMed1994

[Nasal hyperreactivity and neuropeptides].

The Authors define nasal-sinusal hyperreactivity and closely investigate the influence it has on the relationship existing among the Central Nervous System, Peripheric Nervous System, Immunitary System and Nasal Mucosa. Particular reference is made to neuropeptides that seem to be true "bridge" substances between the Nervous System and some components of the Immunitary System. Importance of the P-Substance is emphasized.

Humans↗
PubMed1994

[Nasal polyps and substance P: a preliminary report].

Nasal-sinusal polyposis is a disease with a multifactorial pathogenesis that is often indicative of focal hyperactivity. In the human nasal mucosa are present trigeminal nervous fibres which release Substance P and other neuropeptides in reply to multiple stimuli. Employing immunohistochemical methods the Authors studied the presence and the distribution of SP in tissue biopsies made during surgery in 18 patients with a non-allergic nasal polyposis. In 8 cases, including all those subjects with recurrences, an immunohistochemical positivity towards SP was noticed. The Authors suggest possible involvement of SP in the pathogenesis of some forms of nasal polyposis.

Antibodies, Monoclonal↗
PubMed1994

[Nasal polyps: a possible aspects of nasal hyperreactivity].

The Authors critically examine the principal theories which have emerged during the past years with regard to etiopathogenesis of nasal polyposis. In particular a hypothesis of immunoallergologic nature is set forth and the possibility of interaction between the Nervous System and some elements of the Immunitary System is indicated. Factors giving rise to the genesis of nasal-sinusal polyps are also specified.

Airway Obstruction↗
PubMed1992

Expression of epidermal growth factor receptor and transforming growth factor alpha in human larynx carcinoma.

Altered expression of growth factors and growth factor receptors is frequently described in human tumors and human tumor cell lines. This further supports the hypothesis that oncogenesis is due to the subversion of mitogen-responsive pathways. The aim of this study was to investigate the expression of epidermal growth factor receptor (EGFR) and transforming growth factor alpha (TGF alpha) in 13 larynx carcinomas and 2 carcinomas of the oral cavity. We found receptor overexpression in 7 out of 15 tumors at mRNA and/or protein level but low expression in the majority of the normal adjacent tissues. TGF alpha was expressed only in 1 case, but no tyrosine kinase activity of the receptor was detected by antiphosphotyrosine antibody.

Aged↗
PubMed1990

[Prevalence of squamous carcinoma of the larynx].

A study was made to determine how prevalent laryngeal cancer proved to be in 2000 E.N.T. out-patients upon their initial examination. The aim was to ascertain which population was at high risk for laryngeal cancer through the use of computerized analysis of the risk factors. Furthermore, the authors wanted to determine the sensitivity, specificity, predictive value and safety of fiberoptic laryngoscopy as a diagnostic tool to be used in screening. By scanning risk factors for laryngeal cancer, subjects were classified into 3 risk classes: low, medium and high. A total of 71 positive endoscopic tests were found in the high risk class alone. Further diagnostic procedures carried out on these subjects revealed 38 cases of invasive cancer, 43 'in situ' carcinoma and 24 precancerous lesions of the larynx. These data are discussed and the suggestion made that screening for laryngeal cancer only include males over the age of 40. Scanning risk factors such as tobacco and alcohol consumption could also be effective in identifying the high risk groups for laryngeal cancer.

Adult↗
PubMed1990

[Prevalence of cancer of the oral cavity and oropharynx].

A study was made to determine how prevalent oral and oropharyngeal cancer proved to be in 600 E.N.T. out-patients upon their initial examination. The aim was to ascertain which population was at high risk for thys type cancer through the use of computerized analysis of the risk factors. By scoring risk factors for oral and oropharyngeal cancer, subjects were classified into 3 risk classes: low, medium and high. Endoscopy proved positive in 22 cases only in the high risk class. Further diagnostic procedures, performed for all subjects, revealed 16 cases of squamous cell carcinoma, 1 'in situ' carcinoma, and 5 precancerous lesions of the oral cavity and oropharynx. This data is then discussed and the suggestion made that scoring such risk factors as tobacco and alcohol consumption could also be effective in identifying the high risk groups for this disease in a selective screening program.

Adult↗
PubMed1988

[X-ray computed tomography in latero-cervical lymph nodes, clinically undetectable, in preoperative staging of malignant neoplasms of the larynx].

Postoperative CT of the latero-cervical lymph nodes was carried out in 25 patients suffering from laryngeal cancer. The surgically removed lymph nodes themselves were measured and examined histologically. 529/621 removed lymph nodes (about 85%) were recognisable with CT. The metastasized lymph nodes were clearly identified because of the presence of hypodense, poorly vascularised central foci. Some lymph nodes with a diameter of more than 15 mm on CT investigation proved free from metastatic lesions. This criterion should therefore be considered inadequate for diagnostic purposes. The CT cannot be held to be sufficiently precise to avoid conservative functional latero-cervical emptying as it is probably not able to recognise metastases without capsular rupture, not present in this series.

Adult↗
PubMed1987

Specific lymphokine responses in cervical nodes of patients with laryngeal cancer.

The role of lymphokines in modulating the immune response in patients suffering from neoplastic disease is still controversial. Recent studies indicate that in patients with head and neck cancer, a decrease in LIF (leukocyte migration inhibiting factor) production is usually present in advanced disease. In this study, the authors investigate: the LIF production in lymphocytes derived from the peripheral blood and cervical nodes of patients with laryngeal carcinoma by using an autologous pattern (i.e., for each patient, the specific LIF production was challenged by means of an autologous cell extract derived from his own tumor); the influence of histologically confirmed cervical node metastases on LIF production. Our results indicate that: There is a significant decrease in LIF production in patients with histologically proven cervical node metastases as compared to patients with no metastatic foci. The decrease of LIF production is related to the presence of mononuclear adherent cells. When the latter are removed, there is a significant reversal of specific LIF suppression. The possible meaning of the data is discussed.

Cell Adhesion↗
PubMed1984

Evaluation of blocking mechanisms against immunological responses in patients with laryngeal carcinoma.

The specific tumor-induced leukocyte inhibition factor (LIF) production in laryngeal cancer patients has been investigated before and after the removal of adherent cells in order to evaluate the existence of a suppressor activity; 20 patients served as subject. The LIF production, after challenging the lymphocytes with 3MKC1 autologous tumor extracts, was significant in 12 patients and showed a further significant increase after the removal of adherent cells. In 3 patients with no previous significant LIF production, there was a conversion to significance when the adherent cells were removed. The other patients did not show any significant variation. These data seem to suggest the existence of a suppressor activity exerted by adherent cells in laryngeal cancer patients on LIF production.

Aged↗
PubMed1983

Specific LIF production in laryngeal cancer patients: evidence of suppressor activity exerted by adherent cells.

The specific tumor-induced LIF production in 30 laryngeal cancer patients has been investigated before and after the removal of adherent cells to evaluate the existence of a suppressor activity. LIF production, after challenging lymphocytes with 3 M KCI autologous tumor extracts, was significant in 16 patients and showed a further significant increase after removal of adherent cells. A conversion to significance when the adherent cells were removed was shown in 6 patients, with no previous significant LIF production. These data suggest the existence of a suppressor activity exerted by adherent cells on LIF production in laryngeal cancer patients.

Antigens, Neoplasm↗