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Biomedical subjects

F Bender

Publications and source records attributed to F Bender.

At least 37 records · Page 2Linked to original sources
PubMed1985

Benefit-risk ratio in the treatment of tachyarrhythmias. A clinical judgement.

The goal of antiarrhythmic treatment--the well-being of the patient and improvement of prognosis--requires careful clinical investigation and observation with monitoring of the arrhythmia during long term treatment. A few compounds now in use are under investigation for their efficacy in selectively depressing sinus tachycardia, or tachycardias involving the atrioventricular node. No ideal drug is yet available, nor is likely in the near future, for treating the complex problem of arrhythmogenesis. A favourable benefit-risk ratio for flecainide has been shown by many authors during the last 7 years and greatest interest now centres on its use in malignant arrhythmias. More studies in high risk patients are necessary for a better understanding of the proarrhythmic properties of antiarrhythmic drugs, thus paving the way for prevention and treatment of these unwanted effects.

Anti-Arrhythmia Agents↗
PubMed1985

[Acute and long-term antiarrhythmia effect of encainide in chronic atrial extrasystole].

The antiarrhythmic effects of Encainide in acute intravenous and long-term oral therapy were investigated in 10 patients suffering from chronic atrial ectopic beats previously non-responsive to conventional therapy. The efficacy of Encainide was assessed by 24-hour ECG monitoring during the acute i.v. application and in 4 week intervals over a period of 4 to 6 months. Plasma concentrations of Encainide and the O-demethyl- (ODE) and 3-methoxy-O-demethyl metabolites (3-MODE) were determined after i.v. administration and during oral therapy. A significant reduction of arrhythmias by 76% was found after 1.0 mg/kg Encainide given intravenously. Atrial ectopic beats with bundle branch block QRS-morphology were reduced by more than 90% after only 0.5 mg/kg. During long-term oral therapy 6 of the 9 patients were treated successfully. Following i.v. administration Encainide-plasma concentrations rapidly decreased with a half life of approximately 75 min in the final distribution phase. During oral therapy Encainide levels were not detectable under steady state conditions 4 to 6 hours after the last dose, or they were only minimal, but the average concentrations of ODE and 3-MODE were 71.3 +/- 21.3 and 75.6 +/- 13.5 ng/ml. Encainide increased PR interval and QRS duration significantly. QT-interval changed as a result of the QRS-prolongation. Encainide was well tolerated during acute and chronic therapy. No severe side effects were seen, except in one case, in which dose reduction by 50% was necessary because of blurred vision.(ABSTRACT TRUNCATED AT 250 WORDS)

Administration, Oral↗
PubMed1985

[Therapy of orthostatic dysregulation with gepefrin. Study with continuous telemetric blood pressure monitoring].

The action of the new pressor agent gepefrine (D form of 3-hydroxyphenyl-2-aminopropan) was evaluated in 16 patients with typical clinical symptoms of orthostatic adjustment disorders. The blood pressure measured in the brachial artery (percutaneous puncture and catheterisation according to the Seldinger technique) and the electrocardiogram were transmitted by telemetry and continuously documented under standard conditions at rest, on standing and during a step test. One hour after oral administration of 30 mg or 45 mg gepefrine the blood pressure increased significantly at rest and more markedly on standing and during the step test. Gepefrine led to a reduction in pathological orthostatic regulation during the early phase as well as to the prevention of subjective and objective signs of orthostatic adjustment disorder during the late phase. Patients with insufficient rise in blood pressure during the step test (80 watts) showed after gepefrine a distinct tendency towards normalisation and the regression of subjective states of exhaustion. Gepefrine caused on average no substantive alternations in heart rate during all phases of the investigation. Complications or side-effects due to the method or the medicament were not observed.

Adolescent↗
PubMed1985

Assessment of the antiarrhythmic profile of the new class I agent diprafenone.

The antiarrhythmic profile of the new compound diprafenone was evaluated using various dog models relevant to conditions in humans. In 8 animals, dose related effects on intracardiac conduction, atrial and ventricular refractoriness, fibrillation thresholds and on hemodynamics were determined. In this part of the study also the comparative actions of propafenone were assessed (8 animals). IN another 28 dogs the antiarrhythmic and antifibrillatory actions of diprafenone following short-term coronary occlusion and subsequent release were established. In additional 16 animals the effects of diprafenone on "delayed" reperfusion arrhythmias following release of coronary artery occlusion after 2 h and on stimulus-induced ventricular tachycardia in acute myocardial infarction were investigated. The results show: Diprafenone slows conduction through all parts of the AV-conduction system. The AH-interval is significantly prolonged, QRS-duration and ventricular repolarization are slightly lengthened, and both the atrial and ventricular refractory periods and fibrillation thresholds are markedly increased. Heart rate is slowed, aortic pressure and cardiac output are not significantly changed. Following acute short-term coronary artery occlusion, the incidence of ventricular fibrillation is reduced, and the drop in the ventricular fibrillation threshold is diminished. By contrast, the frequency of ventricular fibrillation after release of short-term occlusion is not influenced. "Delayed" reperfusion arrhythmias, however, are completely abolished, and initiation of ventricular tachycardia in myocardial infarction can be easily prevented. With a predominant local anesthetic mechanism of action and a potential additional beta-sympatholytic activity, the new compound displays close similarities to propafenone.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1985

[Clinical aspects of the aging heart].

Diagnostic and therapeutic procedures in the ageing heart require a holistic approach considering polypathology and polypharmacology of the diseased organism. Adaptation to stress is inadequate due to a delayed and reduced reaction of the sympathetic nervous system. Vagal disturbances are discussed as well. Coronary heart disease and its complications, bradyarrhythmias and premature atrial and ventricular contractions and congestive heart failure dominate the clinical picture of the elderly patient. These clinical entities represent the main causes for death at higher age. Pharmacotherapy has to be adjusted according to differences in absorption, pharmacokinetics and pharmacodynamics, drug interferences and an age specific spectrum of side effects.

Age Factors↗
PubMed1979

[Investigations of iron and folate levels in serum after implantation of heart valve prostheses (author's transl)].

In 90 patients with prosthetic heart valves, the presence of iron and folate deficiencies was assessed in a double-blind study. Anemia was found in 18 cases. Average serum iron levels were below the normal range and could be incremented significantly through the administration of 193 mg Fe++ daily during a 4-week period. No evidence of folate deficiency was found.

Anemia, Hypochromic↗
PubMed1979

[Transvenous retrieval of central embolized fragments of venous catheters (author's transl)].

The industrial supply with complete venous catheter sets facilitated central venous techniques via various peripheral venous entries. The complication rate by pneumothorax, hemothorax, hemopericardium after perforation of a cardiac cavity and central embolism of catheter fragments are rather rare. Nevertheless the indication for central venous catheterization procedures should be calculated critically in every case because of the hazard of venous thrombosis and embolism or sepsis, which occurs more often. Perforation of a cardiac cavity by venous catheters leads to lethal sequelae in more than 60%. Central embolism of venous catheter fragments without perforation is followed by serious complications in most cases. Therefore the retrieval of the embolized fragment should be attempted by trasvenous technique or by thoracotomy. For the transvenous retrieval a special forceps or the transvenous Dotter retrieval set were very useful in our experience. Centrally embolized catheter fragments were drawn back in three patients after transcutaneous puncture via the femoral vein with two-plane X-ray control.

Adult↗
PubMed1978

[Compensatory mechanisms of haemolysis after surgery with the heart-lung-maschine (author's transl)].

In 20 patients, suffering from various diseases, the extent of haemolysis and the correlation between the rate of haemolysis and various mechanisms of erythrocyte damage in the course of open heart surgery was studied. We investigated haemotological parameters, electrolytes, lactate dehydrogenase before, and 1, 3, 5, and 7 days after operation. Besides free haemoglobin, haptoglobin and haemopexin were determined 5 and 15 minutes after starting perfusior with the heart-lung machine and after finishing. The best index of haemolysis was free haemoglobin in the serum. With increasing duration of perfusion the rate of haemolysis increased. Compensating mechanisms were postoperative increase of haptoglobin and haemopexin.

Cardiac Surgical Procedures↗
PubMed1978

[Hemodynamic effects of aldosterone antagonists in patients with mitral stenosis (author's transl)].

In 12 patients with mitral stenosis of a severity that surgery was required, some hemodynamic parameters after intravenous injection of 400 mg Kaliumcanrenoat were studied. The hemodynamic changes were noted after 15 min and reached maximal values after 60 min. The increased values of pulmonary wedge, pulmonary artery and right atrial pressures were significantly reduced and the cardiac index and stroke volume index augmented, with unchanged systemic arterial pressure. Thus, a remarkable relief from pulmonary congestion followed, accompanied by an increase of the left-ventricular working index.--These results encourage the use of aldosterone antagonists in certain cases suffering from severe mitral stenosis.

Adult↗