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Biomedical subjects

F Bläker

Publications and source records attributed to F Bläker.

At least 37 records · Page 2Linked to original sources
PubMed1981

Infantile periarteritis nodosa. Case report and review of the literature.

The clinical and autopsy findings of a three-month-old male infant with infantile periarteritis nodosa are described adn the literature reviewed. Different stages of the inflammatory vascular process could be seen in the iliacal, axillary, carotidal, coronary and the small periadrenal-tissue-arteries. Secondary changes were found in the axillary and coronary arteries consisting of aneurysmal dilatation and thrombosis. Fatal myocardial infarction occurred thirty-nine days following hospital admission.

Autopsy↗
PubMed1980

[Immunologic aspects of sinusitis in children (author's transl)].

Paranasal sinus infections can occur as a result of immunologic deficiencies, and may particularly involve local immune reactions. Other causes of sinusitis include allergic mechanisms which result in its occurrence in those diseases which are associated with allergy. The pathogenesis for sinusitis must be defined so that effective therapy can be directed toward underlying defects involved. Such treatment includes replacement therapy for insufficiencies of the immune system, elimination of antigens in hyperergic reactions, and antibiotics for bacterial infections.

Child↗
PubMed1979

[Flow sheets of urine samples in haemolytic uraemic syndrome. Examinations by analytic isotachophoresis (author's transl)].

In 29 urinary fractions of six children with haemolytic uraemic syndrome (HUS) a specific substance could be demonstrate during the acute phase of the disease by means of isotachophoresis. Urine tests in six patients with other kidney diseases and with uraemia and in seven healthy persons did not show this substance. From this, we assume that the substance demonstrated in the isotachogram has a direct correlation to the HUS.

Acute Disease↗
PubMed1979

[Immunosuppression (author's transl)].

Among different procedures of immunosuppression in man medical treatment with cytotoxic drugs has become the most important. Biological methods are still under development but promise to gain in importance since they are more specific and have fewer side effects. The clinical effect of immunosuppressive therapy in organ transplantation is undisputed. Its effects has been proven in some but not all immuno-inflammatory diseases. Before immunosuppressive therapy is started it must be known whether it is effective in the particular disease involved. The severity of the disease has to be critically balanced against the possible side effects of cytotoxic drugs.

Adrenal Cortex Hormones↗
PubMed1978

[Treatment of severe haemolytic-uraemic syndrome by dialysis (author's transl)].

Since 1973 haemodialysis was performed on 30 children with severe haemolytic-uraemic syndrome. Serial measurements were made of blood pressure, blood picture, renal function, complement values, excretion of fibrinogen split-products and beta2-microglobulin in urine. Of 22 children in the acute severe stage two died, in one case treatment having been started too late, in the other as a result of fulminating pneumococcal pneumonia. Twenty children survived without residual symptoms and with normal renal function. Of six children with severe progressive haemolytic-uraemic syndrome two developed terminal renal failure. In one child a renal transplantation has since been performed. One child requires chronic dialysis after nephrectomy. Three children died as a result of arterial hypertension, one of yeast septicaemia. Of two children with recurrent haemolytic-uraemic syndrome one developed terminal renal failure which was successfully treated by renal transplantation. One child died in a hypertensive crisis. The overall death rate of the group was 23%, in the group with the acute severe haemolytic-uraemic syndrome it was 9%. The results suggest that haemodialysis significantly improves the prognosis of severe haemolytic-uraemic syndrome.

Blood Pressure↗
PubMed1978

The basis of immunosuppressive treatment in ulcerative colitis.

Clinical signs and immunological findings suggest that causation and subsequent progress of ulcerative colitis are related to the body's immune systems. Among the immunological findings, the following are of special importance: the appearance of humoral antibodies against colonic antigens, the presence of specific adapted lymphocytes against fetal colonic epithelium, the decrease of complement (especially in severe types of the disease), and immunohistological changes in the colonic mucosa. The histological changes in the region of the affected segment of intestine and the regional lymphnodes are also characteristic of an immuno-inflammatory disease. However, it is not yet known whether the immunological mechanism is responsible for causing the disease or whether it occurs together with a disease which has no immunological basis.

Antibodies↗