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Biomedical subjects

F Cappello

Publications and source records attributed to F Cappello.

At least 55 records · Page 3Linked to original sources
PubMed1985

The action of interferons on the morphology of mononuclear elements of human peripheral blood. S. E. M. observations.

Scanning electron microscopy has been used to study the surface of lymphocytes and monocytes before and after treatment with interferon in vitro. Aliquots of peripheral blood isolated cells have been tested using either human leucocytic interferon (HuIFN-alpha) and human fibroblast interferon (HuIFN-beta) and both types combined. The investigation has been performed at various incubation times. The freshly isolated untreated lymphocytes exhibit a rough and villous surface. The smooth forms are uncommon. The treatment by various interferon types induces a new distribution of villous and rough structures as well as the forming of new elements called "uropods" and "pseudopods". At the same time, the binding of lymphocytic elements is enhanced by "cytoplasmic bridges" coming even to real "cellular fusions". Later, macrophages are also involved in these phenomena. These observations seem to confirm the hypothesis that the lymphocyte surface performs significant functions in detecting its surroundings and clearly underlines this cell capacity of reacting to specific substances such as interferons.

Cell Membrane↗
PubMed1984

Use of B.C.G. as loco-regional aspecific immunostimulator in cervical carcinoma.

This study concerns the possible use of BCG in oncologic gynecology for loco regional stimulation or loco aspecific active immunotherapy. The Authors administered BCG into the portio of 45 women affected by cervical cancer (stage I and stage II) immediately after the cytohistologic diagnosis and 21 days before the surgical intervention. The Authors conclude that the submucosal inoculation of BCG into the portio causes hyperplastic reactions in this area and in the locoregional lymphatic system with stimulation of the T-lymphocytes and with production of Interferon. Anyway this stimulation has a limited duration.

Female↗
PubMed1982

Use of B.C.G. as loco-regional aspecific immunostimulator in cervical carcinoma.

This study concerns the possible use of BCG in oncologic gynecology for loco regionauthorsl stimulation or loco aspecific active immunotherapy. The authors administered BCG into the portio of 45 women affected by cervical cancer (stage I and stage II) immediately after the cytohistologic diagnosis and 21 days before the surgical intervention. The authors conclude that the submucosal inoculation of BCG into the portio causes hyperplastic reactions in this area and in the loco-regional lymphatic system with stimulation of the T-lymphocytes and with production of Interferon. Anyway this stimulation has a limited duration.

BCG Vaccine↗